The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection
Halliday A, Gillinder L, Lai A, Seneviratne U, Fontenot H, Cameron T, McLean K, Niemiec A, Raghupathi R, Ganguly T, Ellis C, Conrad E, Briggs R, Bulluss K, Kwan P, Perucca P, O'Brien T, McGonigal A, Gutman M, Papacostas J, Fong M, Lee A, Crompton D, Laing J, Wijayath M, Morokoff A, Murphy M, D'Souza W, Cook M. The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection. Epilepsia 2025 PMID: 40445205, DOI: 10.1111/epi.18458.Peer-Reviewed Original ResearchAdverse eventsInterictal dischargesScalp video-EEG monitoringProcedure-related adverse eventsFirst-in-human studyDevice-related adverse eventsEEG recordingsScalp recordingsVideo-EEG monitoringLong-term seizure monitoringClinically relevant findingsPotential clinical utilityTemporal seizure focusScalp EEG recordingsPatient self-reportPostsurgical painHypothalamic hamartomaElectrographic seizuresAdult patientsBilateral recordingsUnilateral recordingsPatient groupPrimary outcomeSeizure frequencyLong-term EEG recordings
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