2024
Health-seeking behaviour and patient-related factors associated with the time to TB treatment initiation in four African countries: a cross-sectional survey
Sathar F, Charalambous S, Velen K, Fielding K, Rachow A, Ivanova O, Rassool M, Lalashowi J, Owolabi O, Nhassengo P, Chihota V, Evans D. Health-seeking behaviour and patient-related factors associated with the time to TB treatment initiation in four African countries: a cross-sectional survey. BMJ Public Health 2024, 2: e001002. PMID: 40018527, PMCID: PMC11816287, DOI: 10.1136/bmjph-2024-001002.Peer-Reviewed Original ResearchTB treatment initiationCross-sectional surveyTB symptomsPrimary care facilitiesTreatment initiationMedian total delayHealth-seeking behaviorNational TB Control ProgrammeTB treatmentCohort of adultsTB control programmesActive case findingPatient-related factorsHealth facilitiesTB servicesHIV prevalenceCare facilitiesDrug-susceptible pulmonary TBTotal delaySecond-leading causeTime to treatment initiationCase findingCox regression modelsStructured questionnaireInitiation of treatmentEnhanced Tuberculosis Diagnosis With Computer-aided Chest X-ray and Urine Lipoarabinomannan in Adults With HIV Admitted to Hospital (CASTLE Study): A Cluster Randomized Trial
Burke R, Nyirenda S, Mtenga T, Twabi H, Joekes E, Walker N, Nyirenda R, Gupta-Wright A, Nliwasa M, Fielding K, MacPherson P, Corbett E. Enhanced Tuberculosis Diagnosis With Computer-aided Chest X-ray and Urine Lipoarabinomannan in Adults With HIV Admitted to Hospital (CASTLE Study): A Cluster Randomized Trial. Clinical Infectious Diseases 2024, 80: 1143-1151. PMID: 38748183, PMCID: PMC12135911, DOI: 10.1093/cid/ciae273.Peer-Reviewed Original ResearchCluster randomised trialTB treatment initiationUsual careChest X-rayPlus usual careUsual care armRandomised trialsTB diagnosisUrine lipoarabinomannanAntiretroviral therapyTreatment initiationDiagnostic armZomba Central HospitalIntention-to-treat analysisTB diagnosticsAdmitted to hospitalModified intention-to-treat analysisCare armCD4 cell countDigital chest X-rayUndiagnosed TBPost-recruitmentCause of deathSecondary outcomesPrimary outcome
2023
A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
Katamba A, Gupta A, Turimumahoro P, Ochom E, Ggita J, Nakasendwa S, Nanziri L, Musinguzi J, Hennein R, Sekadde M, Hanrahan C, Byaruhanga R, Yoeli E, Turyahabwe S, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Kiwanuka N, Davis J. A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial. BMC Public Health 2023, 23: 1568. PMID: 37592314, PMCID: PMC10436440, DOI: 10.1186/s12889-023-16510-0.Peer-Reviewed Original ResearchConceptsContact investigationClinical effectiveness outcomesPrimary implementation outcomeTB contact investigationTB preventative therapyTB treatment initiationTimely TB diagnosisTrial registrationThe trialTuberculosis contact investigationCluster-randomised trialHigh-burden settingsImplementation-effectiveness trialEvidence-based interventionsUganda National CouncilWorld Health OrganizationProportion of contactsTB evaluationPeer-reviewed journalsMiddle-income countriesTreatment initiationTB diagnosisPreventative therapyUndiagnosed personsInfectious deathSputum samples
2015
Human Immunodeficiency Virus Infection-Associated Mortality during Pulmonary Tuberculosis Treatment in Six Provinces of China.
Lai YJ, Liu EY, Wang LM, Morano JP, Wang N, Khoshnood K, Zhou L, Cheng SM. Human Immunodeficiency Virus Infection-Associated Mortality during Pulmonary Tuberculosis Treatment in Six Provinces of China. Biomedical And Environmental Sciences 2015, 28: 421-8. PMID: 26177902, DOI: 10.3967/bes2015.059.Peer-Reviewed Original ResearchConceptsRisk factorsMiliary TBTB treatmentHuman immunodeficiency virus (HIV) infection epidemicSignificant mortality risk factorsAntiretroviral therapy administrationEarly TB diagnosisLow CD4 countSmear-negative TBTB treatment initiationTuberculosis-related deathsPulmonary TB patientsTB/HIVProspective cohort studyImmunodeficiency syndrome (AIDS) patientsTime of diagnosisMortality risk factorsPulmonary tuberculosis treatmentRisk of deathNumber of HIVStrong risk factorLogistic regression analysisYears of ageNon-Han ethnicityCD4 countSuccessful Tuberculosis Treatment Outcomes among HIV/TB Coinfected Patients Down-Referred from a District Hospital to Primary Health Clinics in Rural South Africa
Jacobson KB, Moll AP, Friedland GH, Shenoi SV. Successful Tuberculosis Treatment Outcomes among HIV/TB Coinfected Patients Down-Referred from a District Hospital to Primary Health Clinics in Rural South Africa. PLOS ONE 2015, 10: e0127024. PMID: 25993636, PMCID: PMC4438008, DOI: 10.1371/journal.pone.0127024.Peer-Reviewed Original ResearchConceptsTB treatment outcomesTB/HIVTreatment outcomesHIV clinicDistrict hospitalRetained patientsTreatment completionTreatment successRural South AfricaSuccessful tuberculosis treatment outcomeMajor public health threatDrug-susceptible TBHospital HIV clinicLinkage of careTB treatment completionTB treatment initiationTB treatment servicesTuberculosis treatment outcomesHIV/TBBaseline disease severityNew TB casesPrimary health clinicsPrimary care levelSpecific clinical criteriaHigher treatment success
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