2023
ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis
Guo C, Xiao Y, Gu J, Zhao P, Hu Z, Zheng J, Hua R, Hai Z, Su J, Zhang J, Yeung W, Wang T. ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis. Communications Biology 2023, 6: 1012. PMID: 37798322, PMCID: PMC10556007, DOI: 10.1038/s42003-023-05372-2.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseMitochondrial functionActivate mitochondrial unfolded protein responseMTORC1 signalingMale germ cellsAffecting energy supplyUnfolded protein responseRapamycin treatment in vivoConditional knockoutMatrix peptidasesProteolytic subunitProtein homeostasisDecreased testicular sizeRegulating meiosisSeminiferous tubulesProtein responseGerm cellsSpermatogenesisClpXClpPMTORC1 pathwaySpermatocytesVacuolar structuresMeiosisTesticular size
2015
Natural history of testicular size in boys with varicoceles
Khasnavis S, Kogan B. Natural history of testicular size in boys with varicoceles. Journal Of Pediatric Urology 2015, 11: 148.e1-148.e5. PMID: 25957187, DOI: 10.1016/j.jpurol.2015.02.014.Peer-Reviewed Original ResearchConceptsLeft-sided varicoceleTesticular volumeThird visitLeft testicleFifth visitTesticular sizeAdolescent varicocele patientsLeft testicular volumeRecent European AssociationSingle-operator studyTesticular size discrepancyRisk of overtreatmentNon-surgical approachPresent study populationGrade 3 varicocelesPubertal age groupPediatric varicoceleBilateral varicoceleUrology guidelinesConsecutive patientsSurgical managementRandomized trialsUnaffected sideSubgroup analysisFuture fertility
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