2016
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
Wang X, Bey AL, Katz BM, Badea A, Kim N, David LK, Duffney LJ, Kumar S, Mague SD, Hulbert SW, Dutta N, Hayrapetyan V, Yu C, Gaidis E, Zhao S, Ding JD, Xu Q, Chung L, Rodriguiz RM, Wang F, Weinberg RJ, Wetsel WC, Dzirasa K, Yin H, Jiang YH. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nature Communications 2016, 7: 11459. PMID: 27161151, PMCID: PMC4866051, DOI: 10.1038/ncomms11459.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutism Spectrum DisorderBehavior, AnimalCerebral CortexCorpus StriatumFemaleHomer Scaffolding ProteinsHumansLong-Term Synaptic DepressionMaleMiceMice, KnockoutMicrofilament ProteinsModels, NeurologicalNerve NetNerve Tissue ProteinsReceptor, Metabotropic Glutamate 5Sequence DeletionSocial BehaviorConceptsASD-like behaviorsCircuit mechanismsStriatal synaptic plasticityAutism spectrum disorderAbnormal brain morphologyPathophysiology of ASDNeural circuit mechanismsHuman neuroimaging studiesKnockout mouse modelAberrant neural connectivityCircuit abnormalitiesStriatal neuronsStriatal synapsesCorticostriatal connectivityBehavioral deficitsAberrant structural connectivityMouse modelThalamic circuitsExcessive groomingSynaptic plasticityBrain morphologyNeuroimaging studiesSHANK3 geneNeural connectivityKnockout models
2011
Distinct but overlapping neural networks subserve depression and insecure attachment
Galynker II, Yaseen ZS, Katz C, Zhang X, Jennings-Donovan G, Dashnaw S, Hirsch J, Mayberg H, Cohen LJ, Winston A. Distinct but overlapping neural networks subserve depression and insecure attachment. Social Cognitive And Affective Neuroscience 2011, 7: 896-908. PMID: 22037687, PMCID: PMC3501706, DOI: 10.1093/scan/nsr074.Peer-Reviewed Original ResearchConceptsSub-cortical activityBeck Depression InventoryEffect of depressionLevel-dependent responsesSub-cortical componentsCortico-striatoCortical effectsDepression scoresThalamic circuitsDepression InventoryCortical encodingDepressionFMRI scanningBrain activityNeural mechanismsPsychotherapeutic outcomeInsecure attachmentScoresSame circuitryFemale strangerMultiple linear regressionLater attachmentLinear regressionPatientsAttachment insecurity
2007
Thalamic synchrony and dynamic regulation of global forebrain oscillations
Huguenard J, McCormick D. Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends In Neurosciences 2007, 30: 350-356. PMID: 17544519, DOI: 10.1016/j.tins.2007.05.007.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesRelay neuronsReticular nucleusInhibitory thalamic reticular neuronsThalamic oscillatory activityGeneralized absence epilepsyThalamic reticular neuronsThalamocortical relay neuronsRegulation of excitabilityPost-inhibitory rebound mechanismAnnual INMED/TINS symposiumINMED/TINS special issue PhysiogenicThalamic synchronyReticular neuronsAbsence epilepsySynaptic connectivityThalamic circuitsThalamocortical networkSpindle generationThalamic networkPathological oscillationsOscillatory activitySpecific interventionsSleep spindlesGenetic alterations
1999
Chapter 17 Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges
Destexhe A, McCormick D, Sejnowski T. Chapter 17 Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges. Progress In Brain Research 1999, 121: 289-307. PMID: 10551033, DOI: 10.1016/s0079-6123(08)63080-0.Peer-Reviewed Original Research
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