2024
The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia: A Gene-Environment Interaction Study.
Wang X, Zhong C, Ma X, Metayer C, Mancuso N, Gauderman W, Wiemels J. The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia: A Gene-Environment Interaction Study. Cancer Epidemiology Biomarkers & Prevention 2024, 34: 100-107. PMID: 39495115, PMCID: PMC11981794, DOI: 10.1158/1055-9965.epi-24-1037.Peer-Reviewed Original ResearchPrenatal tobacco exposureTobacco exposureGene-environment interaction studiesNon-Latino white childrenAcute lymphoblastic leukemia riskChildhood ALL riskRepair genesGene-environment interactionsAcute lymphoblastic leukemiaStatistically significant interactionPotential risk factorsDNA repair genesTobacco smokeLatino childrenPediatric oncologyALL riskTargeted preventionWhite childrenLogistic regressionEpidemiological studiesEnvironmental exposuresRisk factorsTobaccoGenotype dataSignificant interaction
2023
Opioid use disorder amongst young people living with HIV: A 10-year trend
Ikekwere J, Eiger R, Heward B, Longcoy J, Okobi O, Oladunjoye A, Onyeaka H, Kompella S, Jegede O. Opioid use disorder amongst young people living with HIV: A 10-year trend. Psychiatry Research Communications 2023, 3: 100140. DOI: 10.1016/j.psycom.2023.100140.Peer-Reviewed Original ResearchOpioid use disorderMental health diagnosesUse disordersDiagnosis of OUDRisk of OUDNational Inpatient Sample dataMajor public health concernNew HIV diagnosesMultivariable logistic regressionMental health servicesHIV-positive young peoplePublic health concernMental health issuesComorbid HIVHIV diagnosisOpioid useOUD diagnosisEffective treatmentHigh riskHIVPrevention strategiesICD codesTargeted preventionDrug useHealth services
2022
Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study
Isaksson J, Ruchkin V, Aho N, Lundin Remnélius K, Marschik P, Bölte S. Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study. Molecular Autism 2022, 13: 8. PMID: 35183250, PMCID: PMC8858556, DOI: 10.1186/s13229-022-00487-5.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderAutism spectrum disorderNeurodevelopmental conditionsCo-twin designHyperactivity disorderSpectrum disorderCo-twin control studyEarly environmental riskLower IQAutismEtiology of autismIntellectual disabilityPrevious researchEarly interventionEarly childhoodConclusionsThe findingsPostnatal riskEquation modelMonozygotic co‐twin control studyBackgroundA significant proportionRisk loadSeparate risk factorsTwin pairsTargeted preventionWeight discordanceCross-substance patterns of alcohol, cigarette, and cannabis use initiation in Black and White adolescent girls
Sartor CE, Ye F, Simon P, Zhai ZW, Hipwell AE, Chung T. Cross-substance patterns of alcohol, cigarette, and cannabis use initiation in Black and White adolescent girls. Preventive Medicine 2022, 156: 106979. PMID: 35124100, PMCID: PMC8922285, DOI: 10.1016/j.ypmed.2022.106979.Peer-Reviewed Original ResearchConceptsTiming of AlcoholWhite girlsWhite adolescent girlsMultinomial logistic regressionTargeted preventionLogistic regressionSubstance useAdolescent girlsCigarettesCannabisIndividual-level factorsAge 8Black girlsGirlsOnsetCurrent studyInitiationUrban sampleLevel factorsInitiation patternsWhite youth
2021
Symptoms of distress during the COVID-19 pandemic in the United States.
Okafor C, Asare M, Bautista K, Opara I. Symptoms of distress during the COVID-19 pandemic in the United States. American Journal Of Health Studies 2021, 36 PMID: 34335012, PMCID: PMC8321393, DOI: 10.47779/ajhs.2021.638.Peer-Reviewed Original ResearchOdds of feelingSymptoms of distressAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicCoronavirus 2 pandemicGeneral healthRecent smokingPsychosocial factorsTreatment interventionsTargeted preventionYounger ageMental healthCOVID-19 pandemicSymptomsDepressionOddsUnited StatesDistressHealthPandemicSmokingPrevention
2005
p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue
Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD. p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue. Cancer Research 2005, 65: 1792-1799. PMID: 15753376, DOI: 10.1158/0008-5472.can-04-3507.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBreastBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCell NucleusCell ProliferationCyclooxygenase 2CytoplasmEnzyme ActivationEnzyme InhibitorsEpithelial CellsFemaleGene Expression Regulation, EnzymologicHumansMembrane ProteinsMiddle Agedp38 Mitogen-Activated Protein KinasesPhosphorylationPrecancerous ConditionsProstaglandin-Endoperoxide SynthasesProstaglandinsTranscription, GeneticConceptsVariant human mammary epithelial cellsCOX-2 expressionCyclooxygenase-2Human mammary epithelial cellsEpithelial cellsMammary epithelial cellsNormal tissuesOverexpress COX-2COX-2 transcriptsDecreases cell survivalCOX-2 transcriptionRegulates Cyclooxygenase-2Ductal carcinomaPremalignant lesionsReduction mammoplastyBreast cancerNeoplastic processTargeted preventionPremalignant tissuesImmediate early genesEarly carcinogenesisUpstream regulatory pathwaysLesionsCell survivalTissue
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