2024
Gut microbiota and therapy for obesity and type 2 diabetes
Zhang L, Wang P, Huang J, Xing Y, Wong F, Suo J, Wen L. Gut microbiota and therapy for obesity and type 2 diabetes. Frontiers In Endocrinology 2024, 15: 1333778. PMID: 38596222, PMCID: PMC11002083, DOI: 10.3389/fendo.2024.1333778.Peer-Reviewed Original ResearchGut microbiota compositionGut microbiotaMicrobiota compositionType 2 diabetesFunction of gut microbiotaHomeostasis of gut microbiotaMicrobiota-based approachesModulating gut microbiotaBariatric surgeryEffective anti-obesity treatmentQuality of life of individualsMicrobiotaMildly obese patientsSustained weight lossAssociated with obesityDiminished quality of lifeAnti-obesity treatmentObesity management strategiesGutQuality of lifeNon-surgical interventionsIncreased medical costsPublic health crisisMusculoskeletal disordersObese patients
2019
SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia
Nasiri AR, Rodrigues MR, Li Z, Leitner BP, Perry RJ. SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia. Cancer & Metabolism 2019, 7: 10. PMID: 31867105, PMCID: PMC6907191, DOI: 10.1186/s40170-019-0203-1.Peer-Reviewed Original ResearchControlled-release mitochondrial protonophoreInsulin-lowering agentsTumor growthSodium-glucose cotransporter 2 inhibitorsObesity-cancer connectionSustained weight lossCotransporter 2 inhibitorsObesity-associated cancersSubcutaneous insulin infusionInsulin-lowering effectTumor glucose uptakeBreast tumor growthMultiple comparisonsMultiple tumor typesSGLT2 inhibitionSGLT2 inhibitorsObese miceInsulin infusionColon cancer progressionTherapeutic approachesMouse modelBonferroni multiple comparisonsGlucose metabolismColon cancerHyperinsulinemia
2011
Effects of chronic weight perturbation on energy homeostasis and brain structure in mice
Ravussin Y, Gutman R, Diano S, Shanabrough M, Borok E, Sarman B, Lehmann A, LeDuc CA, Rosenbaum M, Horvath TL, Leibel RL. Effects of chronic weight perturbation on energy homeostasis and brain structure in mice. AJP Regulatory Integrative And Comparative Physiology 2011, 300: r1352-r1362. PMID: 21411766, PMCID: PMC3119157, DOI: 10.1152/ajpregu.00429.2010.Peer-Reviewed Original ResearchConceptsDiet-induced obeseEnergy expenditureArcuate nucleus proopiomelanocortin neuronsWeight lossWeight-reduced individualsSustained weight lossReduced body weightObese human subjectsCentral nervous systemHuman subjectsSustained weight gainProopiomelanocortin neuronsBody massUpward resettingMale miceExcitatory synapsesBody fatMouse modelBody weightNervous systemSynaptic changesPersistent decreaseEnergy homeostasisWeight gainBrain structures
2010
Energy intake in weight-reduced humans
Rosenbaum M, Kissileff HR, Mayer LE, Hirsch J, Leibel RL. Energy intake in weight-reduced humans. Brain Research 2010, 1350: 95-102. PMID: 20595050, PMCID: PMC2926239, DOI: 10.1016/j.brainres.2010.05.062.Peer-Reviewed Original ResearchConceptsEnergy intakeWeight lossSustained weight lossSuccessful weight reductionAdipocyte-derived hormoneBody weight maintenanceEnergy expenditureBody composition changesBody energy storesWeight maintenanceBody fatnessBody weightNeuronal signalingIntakeWeight reductionBasis of weightEnergy storesMultiple changesLeptinWeightHormoneResponse
2003
Interest in Healthy Diet and Physical Activity Interventions Peripartum among Female Partners of Active Duty Military
Østbye T, McBride C, Demark-Wahnefried W, Bastian L, Morey M, Krause KM, Brouwer R, Turner B. Interest in Healthy Diet and Physical Activity Interventions Peripartum among Female Partners of Active Duty Military. Military Medicine 2003, 168: 320-325. PMID: 12733678, DOI: 10.1093/milmed/168.4.320.Peer-Reviewed Original ResearchConceptsWeight loss interventionHealthy dietWeight lossSustained weight lossFemale partnersActive duty soldiersPregnancy overweightPeripartum womenActive duty militaryExercise interventionPostpartum periodPhysical activityGeneral populationDuty soldiersEffective interventionsClear healthExercise behaviorInterventionOverweightOne-thirdTeachable momentWomenDietPopulationObese
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