2024
CasRx-based Wnt activation promotes alveolar regeneration while ameliorating pulmonary fibrosis in a mouse model of lung injury
Shen S, Wang P, Wu P, Huang P, Chi T, Xu W, Xi Y. CasRx-based Wnt activation promotes alveolar regeneration while ameliorating pulmonary fibrosis in a mouse model of lung injury. Molecular Therapy 2024, 32: 3974-3989. PMID: 39245939, PMCID: PMC11573616, DOI: 10.1016/j.ymthe.2024.09.008.Peer-Reviewed Original ResearchWnt/b-catenin signalingStem cell activityLung epitheliumAlveolar regenerationPulmonary fibrosisLung fibrosisWnt signalingCell activationMouse models of lung injuryModel of lung injuryWnt activityAlveolar type II cell proliferationBleomycin-induced injuryAmeliorated pulmonary fibrosisActivation of Wnt signalingType II cell proliferationInhibit lung fibrosisRegenerative medicineAnti-fibrotic effectsTreating pulmonary fibrosisActivated Wnt signalingLung injuryMouse modelFibrosisWnt/b-cateninStem cell migration drives lung repair in living mice
Chioccioli M, Liu S, Magruder S, Tata A, Borriello L, McDonough J, Konkimalla A, Kim S, Nouws J, Gonzalez D, Traub B, Ye X, Yang T, Entenberg D, Krishnaswamy S, Hendry C, Kaminski N, Tata P, Sauler M. Stem cell migration drives lung repair in living mice. Developmental Cell 2024, 59: 830-840.e4. PMID: 38377991, PMCID: PMC11003834, DOI: 10.1016/j.devcel.2024.02.003.Peer-Reviewed Original ResearchStem cell migrationCell migrationAlveolar type 2 cellsAlveolar unitsStem cell motilityAlveolar type 1 cellsStem cell activityCellular response to injuryResponse to injuryType 2 cellsMotile phenotypeType 1 cellsCell motilityLung repairImpaired regenerationGenetic depletionCell activationAT2Stem cellsTissue repairAT1Longitudinal imagingInjuryMotilityCellular resolution
2020
Reprogramming of Stem Cell Activity to Convert Thorns into Branches
Zhang F, Rossignol P, Huang T, Wang Y, May A, Dupont C, Orbovic V, Irish VF. Reprogramming of Stem Cell Activity to Convert Thorns into Branches. Current Biology 2020, 30: 2951-2961.e5. PMID: 32559443, DOI: 10.1016/j.cub.2020.05.068.Peer-Reviewed Original ResearchConceptsGene networksShoot stem cell nicheStem cellsTCP transcription factorsExpression of WUSCHELStem cell quiescenceStem cell nicheStem cell activityStem cell proliferationCitrus genesAngiosperm speciesPlant architectureShoot apicalApical meristemTranscription factorsCell nicheCell quiescenceMeristemFunction of componentsWUSCHELCell proliferationConcomitant conversionCrop yieldFunction resultsCells
2019
Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate
Hanoun M, Arnal-Estapé A, Maryanovich M, Zahalka AH, Bergren SK, Chua CW, Leftin A, Brodin PN, Shen MM, Guha C, Frenette PS. Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate. Stem Cell Reports 2019, 12: 1201-1211. PMID: 31130357, PMCID: PMC6565923, DOI: 10.1016/j.stemcr.2019.04.019.Peer-Reviewed Original ResearchConceptsReserve stem cell populationLineage-tracing analysisStem cell populationStem cell activityProstate stem cellsEpithelial cellsBipotential capacityProstate epithelial cellsTissue maintenanceLuminal epithelial cellsMesenchymal cellsStem cellsCell populationsOrgan damageProstate organoidsNG2 expressionRegenerative capacityRare subsetMouse prostateProstate epitheliumTransgenic miceTissue graftCell activityClonal levelCells
2018
Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation
Mesa KR, Kawaguchi K, Cockburn K, Gonzalez D, Boucher J, Xin T, Klein AM, Greco V. Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation. Cell Stem Cell 2018, 23: 677-686.e4. PMID: 30269903, PMCID: PMC6214709, DOI: 10.1016/j.stem.2018.09.005.Peer-Reviewed Original Research
2015
A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation
Sun J, Bonaguidi M, Jun H, Guo J, Sun G, Will B, Yang Z, Jang M, Song H, Ming G, Christian K. A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation. Molecular Brain 2015, 8: 52. PMID: 26337530, PMCID: PMC4559945, DOI: 10.1186/s13041-015-0143-9.Peer-Reviewed Original ResearchConceptsRadial glia-like neural stem cellsSepto-temporal axisAdult dentate gyrusDentate gyrusAdult hippocampal neurogenesisMouse dentate gyrusAdult mouse dentate gyrusHippocampal neurogenesisStem cell activityLevels of adult hippocampal neurogenesisIn situ hybridizationMechanisms regulating proliferationNeural stem cell activityQuantitative real-time PCRNeural stem cellsMCM2 expressionReal-time PCRCell activationMature neuronsPostnatal developmentSFRP3Stem cellsMolecular mechanismsProtein 3Suppressive activity
2014
Chapter Four Epithelial Stem Cells in Adult Skin
Tadeu AM, Horsley V. Chapter Four Epithelial Stem Cells in Adult Skin. Current Topics In Developmental Biology 2014, 107: 109-131. PMID: 24439804, PMCID: PMC5595246, DOI: 10.1016/b978-0-12-416022-4.00004-4.Peer-Reviewed Original ResearchConceptsAdult skin epitheliumTissue-specific stem cellsDifferent stem cell populationsStem cellsStem cell nicheNormal skin homeostasisStem cell populationStem cell activityCell nicheEpithelial stem cellsSkin homeostasisAbnormal regulationCell populationsAdult skinSkin epitheliumExtrinsic componentsEnvironmental aggressionsCellsNicheAdult lifeHomeostasisFirst lineRegulationRecent effortsCell activity
2011
Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Festa E, Fretz J, Berry R, Schmidt B, Rodeheffer M, Horowitz M, Horsley V. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling. Cell 2011, 146: 761-771. PMID: 21884937, PMCID: PMC3298746, DOI: 10.1016/j.cell.2011.07.019.Peer-Reviewed Original ResearchConceptsAdipocyte lineage cellsStem cell nicheStem cell activityLineage cellsCell nicheSkin stem cell nichesStem cell functionEpithelial stem cell nicheStem cell activationEpithelial stem cell functionSkin stem cellsTissue homeostasisNiche cellsFunctional analysisAdipogenic cellsSkin homeostasisMammalian skinTransplantation experimentsStem cellsPrecursor cellsHair cyclingCell functionAdipocyte cellsNicheFunctional tissue
2006
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E. Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland. Cell 2006, 126: 597-609. PMID: 16901790, PMCID: PMC2424190, DOI: 10.1016/j.cell.2006.06.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBromodeoxyuridineCell CountCell DifferentiationCell LineageCell MovementCell ProliferationCells, CulturedEpithelial CellsGene Expression Regulation, DevelopmentalHair FollicleHyperplasiaMiceMice, KnockoutMice, TransgenicMultipotent Stem CellsPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-mycRepressor ProteinsSebaceous GlandsStem CellsTranscription FactorsConceptsMultipotent stem cellsCellular inputsGenetic lineage tracingStem cellsUnipotent progenitor cellsTranscriptional repressor Blimp1Stem cell activityElevated c-myc expressionLineage commitmentC-myc expressionBrdU-labeling experimentsLineage tracingProgenitor populationsLineagesBlimp1Progenitor cellsCell proliferationLabeling experimentsSebaceous glandsCellsCell culture studiesSG homeostasisHair folliclesHomeostasisGland
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