2017
Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies
Chiosa V, Groppa S, Ciolac D, Koirala N, Mişina L, Winter Y, Moldovanu M, Muthuraman M, Groppa S. Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies. Brain Connectivity 2017, 7: 309-320. PMID: 28494616, DOI: 10.1089/brain.2017.0487.Peer-Reviewed Original ResearchConceptsFrontal lobeVentral anterior nucleusThalamo-cortical connectivityFuture therapeutic approachesSpike generationFocal epileptic seizuresMedial dorsalThalamic volumeFocal epilepsyAnterior nucleusFrontal cortexTherapeutic approachesEpileptic seizuresCerebral networksCortical integrityThalamusEEG recordingsWidespread areasDistinct patternsLobeEpileptogenesisPatientsEpilepsySeizuresCortex
2013
Homeostatic Control of Synaptic Transmission by Distinct Glutamate Receptors
Yan D, Yamasaki M, Straub C, Watanabe M, Tomita S. Homeostatic Control of Synaptic Transmission by Distinct Glutamate Receptors. Neuron 2013, 78: 687-699. PMID: 23719165, PMCID: PMC3668311, DOI: 10.1016/j.neuron.2013.02.031.Peer-Reviewed Original ResearchConceptsKainate receptor activityGlutamate receptorsReceptor activitySynaptic transmissionNeuronal activityHigh-affinity kainate receptor subunitKainate receptor-mediated currentsDistinct glutamate receptorsReceptor-mediated currentsAMPA receptor activitySynaptic AMPA receptorsPostsynaptic glutamate receptorsKainate receptor subunitsAbundant excitatory neurotransmitterCerebellar granule cellsReceptor channel propertiesExcitatory neurotransmitterNMDA receptorsAMPA receptorsGranule cellsReceptor subunitsReceptorsSpike generationHomeostatic controlGluK5 subunits
2012
Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites
Jadi M, Polsky A, Schiller J, Mel BW. Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002550. PMID: 22719240, PMCID: PMC3375251, DOI: 10.1371/journal.pcbi.1002550.Peer-Reviewed Original ResearchMeSH KeywordsAction Potentialsalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalcium SignalingComputational BiologyComputer SimulationDendritesExcitatory Postsynaptic Potentialsgamma-Aminobutyric AcidIn Vitro TechniquesMaleModels, NeurologicalN-MethylaspartatePyramidal CellsRatsRats, WistarSomatosensory CortexConceptsPyramidal neuronsDendritic inhibitionInterneuron typesDendritic spikesLayer 5 pyramidal neuronsSpike thresholdDistal dendritic inhibitionInhibitory interneuron typesSpike initiation zoneDendritic spike thresholdDifferent neural pathwaysBasal dendritesSynaptic contactsNeocortical slicesCortical circuitsDendritic responsesNeural pathwaysSomatic inhibitionLocal spikingSpike generationCortical computationRelative activationInhibitionDetailed compartmental modelNeurons
2008
Functional circuitry of visual adaptation in the retina
Demb JB. Functional circuitry of visual adaptation in the retina. The Journal Of Physiology 2008, 586: 4377-4384. PMID: 18617564, PMCID: PMC2614018, DOI: 10.1113/jphysiol.2008.156638.Peer-Reviewed Original ResearchConceptsPresynaptic bipolar cellsGanglion cellsReceptive field centerBipolar cellsGanglion cell receptive field centersPeripheral receptive fieldsBipolar cell inputsContrast adaptationRetinal ganglion cellsBipolar terminalsGlutamate releaseAmacrine cellsSynaptic outputMammalian retinaContrast stimulationFunctional circuitryCellular mechanismsSpike generationCell inputHyperpolarizationReceptive fieldsRetinaResponse saturationField centerCells
2005
Do We Know What the Early Visual System Does?
Carandini M, Demb JB, Mante V, Tolhurst DJ, Dan Y, Olshausen BA, Gallant JL, Rust NC. Do We Know What the Early Visual System Does? Journal Of Neuroscience 2005, 25: 10577-10597. PMID: 16291931, PMCID: PMC6725861, DOI: 10.1523/jneurosci.3726-05.2005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsContrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Boahen K, Demb JB. Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neuroscience 2005, 25: 860-868. PMID: 15673666, PMCID: PMC6725633, DOI: 10.1523/jneurosci.2782-04.2005.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsIntracellular recordingsSubthreshold responsesY-type retinal ganglion cellsY-type ganglion cellsSynaptic mechanismsSynaptic inputsMammalian retinaSpiking responseExtracellular recordingsSubthreshold potentialsContrast sensitivitySpike outputSpike thresholdContrast adaptationSpike generationGain changesCellsRecordingsResponseApparent reductionRecording conditionsAbove effectsMean light level
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