Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings
Boswell K, Watkins T, Cale E, Samsel J, Andrews S, Ambrozak D, Driscoll J, Messina M, Narpala S, Hopp C, Cagigi A, Casazza J, Yamamoto T, Zhou T, Schief W, Crompton P, Ledgerwood J, Connors M, Gama L, Kwong P, McDermott A, Mascola J, Koup R. Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings. Frontiers In Immunology 2022, 13: 1087018. PMID: 36582240, PMCID: PMC9794141, DOI: 10.3389/fimmu.2022.1087018.Peer-Reviewed Original ResearchConceptsB cell subsetsB cell clonesB-cell immortalizationMemory B cellsB cellsCell subsetsCell clonesHIV-1 infected individualsMemory B cell subsetsDifferent B cell populationsIsolation of antibodiesRecent malaria infectionFuture vaccine designCell immortalizationB cell populationsB cell survivalMalaria infectionPrimary B cellsVaccine settingInfection settingsImmunoglobulin secretionHealthy individualsTonsil tissueAntibody secretionBCL-6A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections
Buturovic L, Zheng H, Tang B, Lai K, Kuan W, Gillett M, Santram R, Shojaei M, Almansa R, Nieto J, Muñoz S, Herrero C, Antonakos N, Koufargyris P, Kontogiorgi M, Damoraki G, Liesenfeld O, Wacker J, Midic U, Luethy R, Rawling D, Remmel M, Coyle S, Liu Y, Rao A, Dermadi D, Toh J, Jones L, Donato M, Khatri P, Giamarellos-Bourboulis E, Sweeney T. A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections. Scientific Reports 2022, 12: 889. PMID: 35042868, PMCID: PMC8766462, DOI: 10.1038/s41598-021-04509-9.Peer-Reviewed Original ResearchConceptsSeverity of viral infectionsViral infectionArea under curveViral illnessPredicting 30-day mortalitySevere respiratory failureAcute viral infectionTrained logistic regression classifierViral infected patientsViral infection settingsImprove patient managementReduce healthcare burdenUnmet medical needSeverity of COVID-19Respiratory failureRetrospective cohortInfected patientsClinical studiesPatient managementCross-validation areaHealthcare burdenGene expression assaysPatientsInfection settingsRisk assessment of COVID-19
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