2024
Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors
Lin S, Dai Y, Han C, Han T, Zhao L, Wu R, Liu J, Zhang B, Huang N, Liu Y, Lai S, Shi J, Wang Y, Lou M, Xie J, Cheng Y, Tang H, Yao H, Fang H, Zhang Y, Wu X, Shen L, Ye Y, Xue L, Wu Z. Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors. Genome Medicine 2024, 16: 60. PMID: 38658971, PMCID: PMC11040908, DOI: 10.1186/s13073-024-01325-4.Peer-Reviewed Original ResearchConceptsTumor immune microenvironmentTumor-associated macrophagesTumor cell apoptosisTumor cellsImmune cellsNeuroendocrine tumorsQuantitative immunofluorescenceComposition of immune cellsInfiltration of immune cellsMultiplexed quantitative immunofluorescenceLevel of immune infiltrationScRNA-seqPituitary neuroendocrine tumorsCX3CR1+ macrophagesDiversity of tumorsCell apoptosisSignificance of macrophagesRNA sequencing samplesScRNA-seq dataCX3CR1+Subcutaneous xenograft experimentsImmune microenvironmentSingle-cell RNA sequencingImmunological environmentImmune infiltration
2019
Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus
Tsoi L, Hile G, Berthier C, Sarkar M, Reed T, Liu J, Uppala R, Patrick M, Raja K, Xing X, Xing E, He K, Gudjonsson J, Kahlenberg J. Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus. The Journal Of Immunology 2019, 202: 2121-2130. PMID: 30745462, PMCID: PMC6424612, DOI: 10.4049/jimmunol.1800650.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusIFN responseFood and Drug Administration-approved therapiesSLE skinSystemic lupus erythematosus patientsSystemic lupus erythematosus susceptibility lociIncreased IFN signaturesSmall interfering RNA knockdownComplex autoimmune diseaseRNA sequencing samplesResponse to IFNTranscription factor PITX1Cutaneous lupusGenes in vitroLupus erythematosusType II IFNTreatment optionsHyperinflammatory responseIFN signatureAutoimmune diseasesSkin inflammationSusceptibility lociIFNRNA knockdownControl keratinocytesAtopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Tsoi L, Rodriguez E, Degenhardt F, Baurecht H, Wehkamp U, Volks N, Szymczak S, Swindell W, Sarkar M, Raja K, Shao S, Patrick M, Gao Y, Uppala R, Perez White B, Getsios S, Harms P, Maverakis E, Elder J, Franke A, Gudjonsson J, Weidinger S. Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis. Journal Of Investigative Dermatology 2019, 139: 1480-1489. PMID: 30641038, PMCID: PMC6711380, DOI: 10.1016/j.jid.2018.12.018.Peer-Reviewed Original ResearchConceptsTranscriptomic studiesPaired-end readsRNA sequencing samplesPathophysiology of ADPaired-endHigh-resolution viewStudies of ADAD transcriptomeDrug target predictionRNA sequencingLong noncoding RNAsRNA samplesDysregulated genesNoncoding RNAsRNAPsoriasis transcriptomeTranscriptomeCellular featuresGenesMolecular heterogeneityDisease heterogeneityTranslational impactIL-4 expressionAD skinGlobal architecture
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