2021
Integration of high-resolution promoter profiling assays reveals novel, cell type-specific transcription start sites across 115 human cell and tissue types
Moore J, Zhang X, Elhajjajy S, Fan K, Pratt H, Reese F, Mortazavi A, Weng Z. Integration of high-resolution promoter profiling assays reveals novel, cell type-specific transcription start sites across 115 human cell and tissue types. Genome Research 2021, 32: gr.275723.121. PMID: 34949670, PMCID: PMC8805725, DOI: 10.1101/gr.275723.121.Peer-Reviewed Original ResearchConceptsTranscription start site annotationTranscription start siteGenome-wide association studiesStart siteAccurate transcription start siteCell type-specific usageMapping of promotersPaired-end informationPaired-end readsAnalysis of gene expressionTranscriptomic data setsGENCODE genesRNA annotationGWAS genesPaired-endGenomic positionsGene collectionTissue typesAssociation studiesTranscriptional regulationTranscription assaysBiological communitiesGene expressionHuman diseasesHuman cells
2019
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Tsoi L, Rodriguez E, Degenhardt F, Baurecht H, Wehkamp U, Volks N, Szymczak S, Swindell W, Sarkar M, Raja K, Shao S, Patrick M, Gao Y, Uppala R, Perez White B, Getsios S, Harms P, Maverakis E, Elder J, Franke A, Gudjonsson J, Weidinger S. Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis. Journal Of Investigative Dermatology 2019, 139: 1480-1489. PMID: 30641038, PMCID: PMC6711380, DOI: 10.1016/j.jid.2018.12.018.Peer-Reviewed Original ResearchConceptsTranscriptomic studiesPaired-end readsRNA sequencing samplesPathophysiology of ADPaired-endHigh-resolution viewStudies of ADAD transcriptomeDrug target predictionRNA sequencingLong noncoding RNAsRNA samplesDysregulated genesNoncoding RNAsRNAPsoriasis transcriptomeTranscriptomeCellular featuresGenesMolecular heterogeneityDisease heterogeneityTranslational impactIL-4 expressionAD skinGlobal architecture
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