2017
Data monitoring committees: Promoting best practices to address emerging challenges
Fleming T, DeMets D, Roe M, Wittes J, Calis K, Vora A, Meisel A, Bain R, Konstam M, Pencina M, Gordon D, Mahaffey K, Hennekens C, Neaton J, Pearson G, Andersson T, Pfeffer M, Ellenberg S. Data monitoring committees: Promoting best practices to address emerging challenges. Clinical Trials 2017, 14: 115-123. PMID: 28359194, PMCID: PMC5380168, DOI: 10.1177/1740774516688915.Peer-Reviewed Original ResearchConceptsData monitoring committee membersInterests of study participantsCommittee membersLegal liabilityData monitoring committeeRigid proceduresRegulatory responsesPromote best practiceRegulatory agenciesCommittee chartersMonitoring committeeEffective functioningClinical trialsCommittee processCommitteeBest practicesIndependenceRegulatory scientistsGovernment sponsorsMembersIndustry-sponsored trialsLiabilityCharterBreachSafety data
1994
Pathways signaling the regulatory volume decrease of cultured nonpigmented ciliary epithelial cells.
Civan M, Coca-Prados M, Peterson-Yantorno K. Pathways signaling the regulatory volume decrease of cultured nonpigmented ciliary epithelial cells. Investigative Ophthalmology & Visual Science 1994, 35: 2876-86. PMID: 8188483.Peer-Reviewed Original ResearchConceptsRegulatory volume decreaseNonpigmented ciliary epithelial cellsProtein phosphatase inhibitor okadaic acidCiliary epithelial cellsPhosphatase inhibitor okadaic acidCultured nonpigmented ciliary epithelial cellsInhibitor okadaic acidEpithelial cellsNPE cellsHuman nonpigmented ciliary epithelial cellsCl- channelsCyclic AMPPKC inhibitor staurosporineEndogenous PKC activityOkadaic acidRegulatory responsesIntracellular cAMP concentrationCell typesPKC activatorCalcium-calmodulinPKC activityCell sortingElectronic cell sortingPathwayStaurosporine
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