2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodeling
2018
Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers
Kaullen JD, Owen JS, Brouwer KLR, Heerdt PM, Lien CA, Savarese JJ, Schmith VD. Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers. Anesthesiology 2018, 128: 1107-1116. PMID: 29494403, PMCID: PMC5953789, DOI: 10.1097/aln.0000000000002157.Peer-Reviewed Original ResearchConceptsNeuromuscular blocking agentsBlocking agentRapid onsetPharmacodynamic modelDifferent dose cohortsMuscle twitch heightOffset of effectSingle ascending dosePharmacokinetic/Pharmacodynamic ModelArterial plasma concentrationsIntermediate durationPlasma drug concentration dataSigmoid Emax modelDose-response studyDrug concentration dataConcentration-time dataLow interindividual variabilityDose cohortsED95 dosesAscending dosePredictable pharmacokineticsSevoflurane anesthesiaPopulation pharmacokineticsSingle dosesTwitch height
2016
Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Heerdt PM, Sunaga H, Owen JS, Murrell MT, Malhotra JK, Godfrey D, Steinkamp M, Savard P, Savarese JJ, Lien CA. Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man. Anesthesiology 2016, 125: 1136-1143. PMID: 27749289, DOI: 10.1097/aln.0000000000001386.Peer-Reviewed Original ResearchConceptsCardiopulmonary side effectsHistamine releaseSide effectsBlood pressureHealthy subjectsHeart rateSevoflurane/nitrous oxideDose-escalation clinical trialDynamic airway complianceNeuromuscular-blocking drugsEscalation clinical trialPlasma histamine concentrationSigmoid Emax modelClinical recoveryClinical durationAdductor pollicisTwitch depressionAirway complianceNeuromuscular blockadeClinical trialsPreclinical studiesArterial bloodEmax modelHistamine concentrationCW002
2009
Case report: paradoxical ventricular septal motion in the setting of primary right ventricular myocardial failure
Maslow A, Schwartz C, Mahmood F, Singh A, Heerdt PM. Case report: paradoxical ventricular septal motion in the setting of primary right ventricular myocardial failure. Journal Canadien D'anesthésie 2009, 56: 510-517. PMID: 19475470, DOI: 10.1007/s12630-009-9108-8.Peer-Reviewed Original ResearchConceptsRV myocardial tissueRV ejectionSystemic hypotensionSeptal motionParadoxical ventricular septal motionMyocardial tissueRV fractional areaVentricular septal motionEnd-organ dysfunctionRight heart failureRight ventricular failureMitral valve replacementVentricular systolic functionEarly postoperative periodSystemic organ failureSystemic organ functionSystolic septal motionMultiple inotropesVasopressor administrationVentricular failureEchocardiographic evaluationHemodynamic instabilityInotropic medicationsPostoperative periodSystolic function
2008
Practice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery
Amar D, Desiderio DP, Heerdt PM, Kolker AC, Zhang H, Thaler HT. Practice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery. Anesthesia & Analgesia 2008, 106: 379-383. PMID: 18227288, DOI: 10.1213/ane.0b013e3181602e41.Peer-Reviewed Original ResearchConceptsDouble-lumen tubeFr double lumen tubeLung isolationDLT repositioningThoracic surgeryDouble-lumen tube sizeSized double-lumen tubePilot studyIntraoperative outcome measuresLeft mainstem bronchusProspective pilot studyIntraoperative hypoxemiaAirway traumaTransient hypoxemiaFiberoptic bronchoscopyMainstem bronchusIntraoperative outcomesSimilar incidenceBronchial cuffDLT sizePractice patternsOutcome measuresSurgeryHypoxemiaPatients
2006
Cardiomyopathic Etiology and SERCA2a Reverse Remodeling During Mechanical Support of the Failing Human Heart
Heerdt PM, Klotz S, Burkhoff D. Cardiomyopathic Etiology and SERCA2a Reverse Remodeling During Mechanical Support of the Failing Human Heart. Anesthesia & Analgesia 2006, 102: 32-37. PMID: 16368801, DOI: 10.1213/01.ane.0000183642.09435.ad.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnimalsBiomechanical PhenomenaCalcium-Transporting ATPasesCardiomyopathy, DilatedConfidence IntervalsDatabases, FactualFemaleGene Expression Regulation, EnzymologicHeart-Assist DevicesHumansIn Vitro TechniquesMaleMiddle AgedRatsSarcoplasmic Reticulum Calcium-Transporting ATPasesVentricular RemodelingConceptsLeft ventricular assist deviceForce-frequency relationshipSERCA2a functionMyocardial force-frequency relationshipMyocyte calcium cyclingSERCA2a gene expressionFailing Human HeartVentricular assist deviceChronic failureProportion of trabeculaeReverse remodelingLVAD supportMyopathic originSubtype 2aDCM heartsDisease processSERCA2a mRNAAssist deviceCalcium cyclingHeart samplesAbnormal expressionMyocardial trabeculaeGene expressionMolecular remodelingHuman heart
2002
Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device
Heerdt PM, Schlame M, Jehle R, Barbone A, Burkhoff D, Blanck TJ. Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device. The Annals Of Thoracic Surgery 2002, 73: 1216-1221. PMID: 11996266, DOI: 10.1016/s0003-4975(01)03621-9.Peer-Reviewed Original Research