2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodeling
2008
The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly
Heerdt PM, Park BJ. The Emerging Role of Minimally Invasive Surgical Techniques for the Treatment of Lung Malignancy in the Elderly. Anesthesiology Clinics 2008, 26: 315-324. PMID: 18456216, DOI: 10.1016/j.anclin.2008.01.009.Peer-Reviewed Original ResearchConceptsPerioperative morbidityEarly-stage lung cancerVideo-assisted thoracoscopic lobectomyLung cancer surgeryInvasive operative techniquesInvasive surgical techniquesElderly patientsPulmonary resectionSurgical therapyLung malignancyPreoperative interventionSurgical treatmentCancer surgeryConventional thoracotomyOncologic efficacyThoracoscopic lobectomyGeriatric populationLung cancerAdvanced ageSurgical techniqueOperative techniqueClear associationEmerging RoleGeneral agingMorbidityPractice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery
Amar D, Desiderio DP, Heerdt PM, Kolker AC, Zhang H, Thaler HT. Practice Patterns in Choice of Left Double-Lumen Tube Size for Thoracic Surgery. Anesthesia & Analgesia 2008, 106: 379-383. PMID: 18227288, DOI: 10.1213/ane.0b013e3181602e41.Peer-Reviewed Original ResearchConceptsDouble-lumen tubeFr double lumen tubeLung isolationDLT repositioningThoracic surgeryDouble-lumen tube sizeSized double-lumen tubePilot studyIntraoperative outcome measuresLeft mainstem bronchusProspective pilot studyIntraoperative hypoxemiaAirway traumaTransient hypoxemiaFiberoptic bronchoscopyMainstem bronchusIntraoperative outcomesSimilar incidenceBronchial cuffDLT sizePractice patternsOutcome measuresSurgeryHypoxemiaPatients
2007
Inflammation and outcome after general thoracic surgery
Amar D, Zhang H, Park B, Heerdt PM, Fleisher M, Thaler HT. Inflammation and outcome after general thoracic surgery. European Journal Of Cardio-Thoracic Surgery 2007, 32: 431-434. PMID: 17643996, DOI: 10.1016/j.ejcts.2007.06.017.Peer-Reviewed Original ResearchConceptsC-reactive proteinMajor postoperative complicationsPostoperative complicationsIL-6Non-steroidal anti-inflammatory drug useHigh-sensitivity C-reactive proteinAnti-inflammatory drug usePreoperative C-reactive proteinSensitivity C-reactive proteinImportant postoperative complicationPreoperative albumin levelTertiary cancer centerMarkers of inflammationMarkers of outcomePostanesthesia care unitProspective data collectionGeneral thoracic surgeryLung resectionSystemic inflammationAlbumin levelsConsecutive patientsLow albuminCare unitPoor outcomeCancer CenterPulmonary resection in the elderly
Castillo MD, Heerdt PM. Pulmonary resection in the elderly. Current Opinion In Anaesthesiology 2007, 20: 4-9. PMID: 17211159, DOI: 10.1097/aco.0b013e32801271fa.Peer-Reviewed Original ResearchConceptsElderly patientsLung resectionPulmonary resectionOncologic efficacyLung cancerSurgical techniquePreoperative functional statusHealthy elderly patientsLung cancer populationRisk-benefit relationshipInvasive surgical techniquesNeoadjuvant therapyPerioperative morbiditySurgical therapyPerioperative stressPreoperative interventionConventional thoracotomySurgical managementPalliative carePoor prognosisTumor stageCancer populationFunctional statusGeriatric populationPhysiological reserve