2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalities
2019
Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output
Berlin DA, Manoach S, Oromendia C, Heerdt PM. Automated expiratory ventilation assistance through a small endotracheal tube can improve venous return and cardiac output. Intensive Care Medicine Experimental 2019, 7: 6. PMID: 30627962, PMCID: PMC6326914, DOI: 10.1186/s40635-018-0217-y.Peer-Reviewed Original ResearchConventional positive pressure ventilationExpiratory ventilation assistancePositive pressure ventilationSmall endotracheal tubeMedian cardiac outputVenous returnCardiac outputPressure ventilationEndotracheal tubeArterial pressureConventional ventilationVentilation assistanceLow central venous pressureCentral venous pressureSystemic arterial pressureEVA groupPEEP 0Venous pressureExpiratory pressureStroke volumeControl groupPorcine modelEffective ventilationVentilationHemorrhage
2017
Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution During Hemorrhagic Shock and Resuscitation in Adult Swine
Berlin DA, Peprah-Mensah H, Manoach S, Heerdt PM. Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution During Hemorrhagic Shock and Resuscitation in Adult Swine. Critical Care Medicine 2017, 45: e195-e201. PMID: 27749345, DOI: 10.1097/ccm.0000000000002071.Peer-Reviewed Original ResearchConceptsNoninvasive cardiac output monitoringCardiac output monitoringThermodilution cardiac outputCardiac outputOutput monitoringArtery catheterHemorrhagic shockBolus thermodilutionIntermittent bolus thermodilutionFemoral artery catheterPulmonary artery catheterAdult porcine modelBlood pressure measurementsLaboratory animal investigationFour-quadrant plotLimits of agreementShed bloodBland-Altman analysisAnimal investigationsPlasma lactateThermodilution measurementsResuscitationYorkshire swineAdult swinePorcine model
2015
Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy
Beaudry S, Pick J, Heerdt P. Non-invasive cardiac output monitoring for cesarean delivery under epidural anesthesia in a patient with Marfan syndrome and cardiomyopathy. International Journal Of Obstetric Anesthesia 2015, 25: 82-85. PMID: 26718697, DOI: 10.1016/j.ijoa.2015.11.003.Peer-Reviewed Original ResearchConceptsNon-invasive cardiac output monitoringCardiac outputCardiac output monitoringCesarean deliveryStroke volumeEpidural anesthesiaBaseline valuesMarfan syndromeLeft ventricular ejection fractionOutput monitoringUse of phenylephrineEnd of surgeryIntravascular volume depletionMaternal cardiac outputMitral valve replacementSystemic blood pressureAdequate surgical anesthesiaClose hemodynamic monitoringVentricular ejection fractionAcute blood lossAcute volume overloadStroke volume increaseValve replacementBlood lossBlood pressure
2011
Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles
Heerdt PM, Wagner CL, DeMais M, Savarese JJ. Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles. Journal Of Pharmacological And Toxicological Methods 2011, 64: 111-118. PMID: 21440649, DOI: 10.1016/j.vascn.2011.03.006.Peer-Reviewed Original ResearchConceptsCardiac outputAortic blood flowDrug-induced changesBlood flowAcute drug-induced changesNoninvasive cardiac output monitoringNon-invasive measurementOpen-chest beaglesNeuromuscular blocking drugsPreclinical drug evaluationCardiac output monitoringDrug evaluation studiesML/minSimultaneous CO measurementsBlocking drugsAcute alterationsAortic rootPreclinical screeningChest instrumentationNICOMCO measurementsOutput monitoringDrug evaluationInvasive measurementsInvasive instrumentation
2010
Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ. Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs. Anesthesiology 2010, 112: 910-916. PMID: 20234311, DOI: 10.1097/aln.0b013e3181d31f71.Peer-Reviewed Original ResearchConceptsX ED95Neuromuscular blocking drugsCardiopulmonary side effectsVascular resistanceArterial pressureBlocking drugsCardiac outputHistamine releaseSide effectsMean pulmonary artery pressurePulmonary artery pressurePulmonary vascular resistanceSystemic vascular resistanceMean arterial pressurePulmonary arterial pressureArtery pressureHemodynamic effectsPulmonary complianceVentricular contractilityInspiratory pressureNeuromuscular blockadeVentricular pressureED95Large dosesCW002