2024
Postdural Puncture Headache: Beyond the Evidence
Berg A, Lucas D, Leffert L. Postdural Puncture Headache: Beyond the Evidence. Best Practice & Research Clinical Anaesthesiology 2024 DOI: 10.1016/j.bpa.2024.11.004.Peer-Reviewed Original ResearchPostdural puncture headacheCalcitonin gene-related peptideAccidental dural punctureCerebrospinal fluidRelease of calcitonin gene-related peptideManagement of postdural puncture headacheTreat postdural puncture headacheLabor epidural analgesiaGene-related peptideAutonomic nervous systemCerebrospinal fluid dynamicsEvidence-based recommendationsEpidural analgesiaPuncture headacheDural punctureIntrathecal catheterNeuraxial proceduresCSF lossSphenopalatine ganglionAssociated with activationCerebral arteryCerebral vasodilationChronic manifestationsTherapeutic strategiesRoutine useFentanyl in the Labor Epidural Impacts the Results of Intrapartum and Postpartum Maternal and Neonatal Toxicology Tests
Siegel M, Mahowald G, Uljon S, James K, Leffert L, Sullivan M, Hernandez S, Gray J, Schiff D, Bernstein S. Fentanyl in the Labor Epidural Impacts the Results of Intrapartum and Postpartum Maternal and Neonatal Toxicology Tests. Obstetric Anesthesia Digest 2024, 44: 47-48. DOI: 10.1097/01.aoa.0001005456.46508.bf.Peer-Reviewed Original ResearchEvidence-based clinical practice guidelines on postdural puncture headache: infographics
Uppal V, Russell R, Kalagara H, Leffert L, Narouze S. Evidence-based clinical practice guidelines on postdural puncture headache: infographics. Regional Anesthesia & Pain Medicine 2024, 49: 502-504. PMID: 38373816, DOI: 10.1136/rapm-2024-105280.Peer-Reviewed Original Research
2022
In Response
Pearson ACS, Leffert LR, Kain ZN. In Response. Anesthesia & Analgesia 2022, 135: e3-e4. PMID: 35709456, DOI: 10.1213/ane.0000000000006014.Commentaries, Editorials and LettersBupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC–MS/MS
Mahowald G, Khaliq T, Basu S, Griggs D, Siegel M, Leffert L, Bernstein S, Flood JG, Uljon S. Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC–MS/MS. The Journal Of Applied Laboratory Medicine 2022, 7: 854-862. PMID: 35259249, DOI: 10.1093/jalm/jfac009.Peer-Reviewed Original ResearchThe Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States
Katz D, Bateman B, Kjaer K, Turner D, Spence N, Habib A, George R, Toledano R, Grant G, Madden H, Butwick A, Lynde G, Minehart R, Beilin Y, Houle T, Sharpe E, Kodali B, Bharadwaj S, Farber M, Palanisamy A, Prabhu M, Gonzales N, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Obstetric Anesthesia Digest 2022, 42: 27-28. DOI: 10.1097/01.aoa.0000816828.87126.61.Peer-Reviewed Original ResearchThrombophilias
Toledano R, Leffert L. Thrombophilias. 2022, 313-316. DOI: 10.1007/978-3-030-72487-0_46.Peer-Reviewed Original ResearchHaemophilias
Toledano R, Leffert L. Haemophilias. 2022, 317-321. DOI: 10.1007/978-3-030-72487-0_47.Peer-Reviewed Original ResearchVon Willebrand Disease
Combs D, Leffert L. Von Willebrand Disease. 2022, 323-327. DOI: 10.1007/978-3-030-72487-0_48.Peer-Reviewed Original ResearchLow Molecular Weight Heparin, Unfractionated Heparin and Neuraxial Anaesthesia
Combs D, Leffert L. Low Molecular Weight Heparin, Unfractionated Heparin and Neuraxial Anaesthesia. 2022, 329-335. DOI: 10.1007/978-3-030-72487-0_49.Peer-Reviewed Original ResearchThe relationship between INTEM/HEPTEM coagulation time ratio and heparin plasma concentration in obstetric patients: an exploratory in vitro investigation
Katz D, Leffert L, Getrajdman C, Sison M, Shin DW, Lin HM, Butwick A. The relationship between INTEM/HEPTEM coagulation time ratio and heparin plasma concentration in obstetric patients: an exploratory in vitro investigation. Journal Canadien D'anesthésie 2022, 69: 597-604. PMID: 35102496, DOI: 10.1007/s12630-022-02193-5.Peer-Reviewed Original ResearchConceptsObstetric patientsUnfractionated heparinConcentration of heparinHeparin activityHeparin concentrationPartial thromboplastin time (aPTT) testingCT ratioCare coagulation testsHeparin plasma concentrationsResultsSeventy-seven patientsPartial thromboplastin timeUncomplicated pregnanciesThird trimesterNeuraxial anestheticPlasma concentrationsCoagulation testsThromboplastin timeBlood samplesPatientsHeparinAPTTHematocrit rangeVitro investigationBloodTime ratioInvestigating the Impact of Neuraxial Fentanyl on Results of Maternal and Neonatal Toxicology Testing
Siegel M, Mahowald G, Uljon S, Leffert L, James K, Sullivan M, Hernandez S, Gray J, Schiff D, Bernstein S. Investigating the Impact of Neuraxial Fentanyl on Results of Maternal and Neonatal Toxicology Testing. American Journal Of Obstetrics And Gynecology 2022, 226: s23-s24. DOI: 10.1016/j.ajog.2021.11.084.Peer-Reviewed Original Research
2021
The “Unexplained” Portion of the Gender Pay Gap in Anesthesiology
Pearson ACS, Leffert LR, Kain ZN. The “Unexplained” Portion of the Gender Pay Gap in Anesthesiology. Anesthesia & Analgesia 2021, 134: 44-48. PMID: 34908545, DOI: 10.1213/ane.0000000000005798.Peer-Reviewed Original ResearchPragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular System
Walsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular System. Obstetric Anesthesia Digest 2021, 41: 164-165. DOI: 10.1097/01.aoa.0000796068.53863.3d.Peer-Reviewed Original ResearchIn Response
Bauer ME, Rajasekhar A, Leffert L. In Response. Anesthesia & Analgesia 2021, 133: e60-e61. PMID: 34673734, DOI: 10.1213/ane.0000000000005726.Peer-Reviewed Original ResearchCall to Action: Maternal Health and Saving Mothers: A Policy Statement From the American Heart Association
Mehta LS, Sharma G, Creanga AA, Hameed AB, Hollier LM, Johnson JC, Leffert L, McCullough LD, Mujahid MS, Watson K, White CJ, Committee O. Call to Action: Maternal Health and Saving Mothers: A Policy Statement From the American Heart Association. Circulation 2021, 144: e251-e269. PMID: 34493059, DOI: 10.1161/cir.0000000000001000.Peer-Reviewed Original ResearchConceptsAmerican Heart AssociationMaternal healthMaternal outcomesHeart AssociationAmerican Heart Association MissionHigh maternal mortality rateMaternal mortality surveillanceReproductive health equityMaternal mortality rateDelivery of careMaternal morbidityCardiovascular diseaseMortality surveillanceSaving MothersChild healthMortality rateEpidemiological programEthnic disparitiesHealth equityTime courseHealthy lifeMother's lifeHealthCareOutcomesWhat’s New in Neuraxial Labor Analgesia
Toledano RD, Leffert L. What’s New in Neuraxial Labor Analgesia. Current Anesthesiology Reports 2021, 11: 340-347. PMID: 34466127, PMCID: PMC8390543, DOI: 10.1007/s40140-021-00453-6.Peer-Reviewed Original ResearchNeuraxial labor analgesiaEpidural drug deliveryLabor analgesiaObstetric patientsCesarean delivery anesthesiaNeuraxial analgesiaGeneral anesthesiaDelivery anesthesiaObstetric anesthesiaNeuraxial proceduresCOVID-19Spinal epidural hematoma formationSARS-CoV-2 infectionSerious adverse eventsEmergency cesarean deliveryCommon serious complicationEpidural labor analgesiaEpidural hematoma formationPain of childbirthAnalgesia techniquesEpidural blockadeAdverse eventsCesarean deliveryRisk/benefit decisionsAnesthetic managementLabor prior to cesarean delivery associated with higher post-discharge opioid consumption
Ende HB, Landau R, Cole NM, Burns SM, Bateman BT, Bauer ME, Booth JL, Flood P, Leffert LR, Houle TT, Tsen LC. Labor prior to cesarean delivery associated with higher post-discharge opioid consumption. PLOS ONE 2021, 16: e0253990. PMID: 34242277, PMCID: PMC8270408, DOI: 10.1371/journal.pone.0253990.Peer-Reviewed Original ResearchConceptsDay of surgeryPostoperative pain scoresPain scoresOpioid utilizationOpioid useSurgical proceduresTime pointsHigher postoperative pain scoresPost-cesarean delivery painPost-discharge opioid consumptionAcute post-operative painComplications of CDMaximal pain scoresPost-cesarean analgesiaProspective cohort studyPost-operative painAdditional surgical proceduresNumeric rating scaleIdentification of womenAcademic medical centerNumber of tabletsSet of confoundersPhone two weeksOpioid consumptionOpioid requirementsOn the Importance of Language in Reports Discussing Racial Inequities.
Armstead V, Bucklin B, Bustillo M, Hastie MJ, Lane-Fall M, Lee A, Leffert L, Mackensen GB, Minhaj M, Sakai T, Straker T, Thenuwara K, Whitlock E, Whittington R, Wiener-Kronish J, Wong C. On the Importance of Language in Reports Discussing Racial Inequities. Anesthesia And Analgesia 2021, 132: e117-e118. PMID: 34032683, DOI: 10.1213/ANE.0000000000005534.Peer-Reviewed Original ResearchThe Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States
Katz D, Bateman BT, Kjaer K, Turner DP, Spence NZ, Habib AS, George RB, Toledano RD, Grant G, Madden HE, Butwick AJ, Lynde G, Minehart RD, Beilin Y, Houle TT, Sharpe EE, Kodali B, Bharadwaj S, Farber MK, Palanisamy A, Prabhu M, Gonzales NY, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Anesthesia & Analgesia 2021, 133: 462-473. PMID: 33830956, DOI: 10.1213/ane.0000000000005592.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesia, ObstetricalAnesthesia, GeneralAnesthesia, ObstetricalCase-Control StudiesCesarean SectionCOVID-19Delivery, ObstetricFemaleGestational AgeHumansInfant, PrematurePregnancyPregnancy Complications, InfectiousPremature BirthRegistriesRisk AssessmentRisk FactorsUnited StatesYoung AdultConceptsSARS-CoV-2 patientsSARS-CoV-2 infectionWeeks of gestationCesarean deliveryObstetric anesthesiaPositive SARS-CoV-2 polymerase chain reaction testSARS-CoV-2 polymerase chain reaction testAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2-infected patientsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreakSyndrome coronavirus 2 infectionMaternal respiratory failureAdverse pregnancy outcomesCoronavirus 2 infectionNeuraxial labor analgesiaUS cohort studyDays of deliveryUS medical centersPolymerase chain reaction testComposite outcome measureAnalysis of outcomesChain reaction testPeripartum outcomesAsymptomatic patients