About
The Department of Anesthesiology relieves the suffering of those in need through the delivery of safe, effective, and timely anesthesia care, advances the field of anesthesiology through excellence in research, and strives to train the next generation of caregivers.
Research
Publications
2026
Epidural Blood Patch Volume: Is More Better?
Wong C, Leffert L. Epidural Blood Patch Volume: Is More Better? Anesthesia & Analgesia 2026 PMID: 42184382, DOI: 10.1213/ane.0000000000008121.Peer-Reviewed Original ResearchStress and fasting for inducing migraine attacks: A randomized 2 × 2 factorial crossover trial
Houle T, Sexton K, Lebowitz A, Chtay I, Patel T, Leffert L, Turner D. Stress and fasting for inducing migraine attacks: A randomized 2 × 2 factorial crossover trial. Headache The Journal Of Head And Face Pain 2026 PMID: 42026859, DOI: 10.1111/head.70105.Peer-Reviewed Original ResearchTrier Social Stress TestEffects of acute stressHeadache onsetSocial Stress TestCumulative incidenceHeadache attacksTrigger of migraine headachesCrossover trialJoint effectsOdds ratioAcute stressSecondary outcomesPrimary outcomeMigraine riskAnalgesic medicationControl taskLaboratory sessionsPreliminary evidenceStudy visitsExperimental manipulationControlled laboratory settingEpisodic migraineParticipantsMigraine attacksBalancing Anticoagulation and Neuraxial Procedures in the Peripartum Period: An Update
Toledano R, Leffert L. Balancing Anticoagulation and Neuraxial Procedures in the Peripartum Period: An Update. Anesthesiology Clinics 2026 DOI: 10.1016/j.anclin.2026.02.015.Peer-Reviewed Original ResearchPrevention and Treatment of Maternal Stroke in Pregnancy and Postpartum
Miller E, Bello C, Chen P, Leffert L, Leppert M, Madsen T, Skeels K, Tita A, Valdes E, Shields A. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum. Obstetrics And Gynecology 2026, 147: e43-e65. PMID: 41678811, DOI: 10.1097/aog.0000000000006197.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPregnancy-associated strokeStroke prevention strategiesPrevention strategiesPrimary stroke prevention strategiesMultidisciplinary rehabilitation teamLife-threatening complicationsPregnancy-related strokeAcute strokeRisk factor modificationSecondary stroke prevention strategiesMaternal-fetal medicine specialistsAcute stroke symptomsEvidence-based treatmentsPrompt treatmentRehabilitation teamLife-threatening complication of pregnancyStroke risk assessmentPostpartum recoveryPersistent disparitiesStroke hospitalizationsCesarean deliveryEvaluation of pregnant patientsVaginal deliveryNeurological careMaternal outcomesPrevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement From the American Heart Association
Miller E, Bello N, Chen P, Leffert L, Leppert M, Madsen T, Skeels K, Tita A, Valdes E, Shields A, in the Young O. Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement From the American Heart Association. Stroke 2026, 57: e127-e145. PMID: 41603019, DOI: 10.1161/str.0000000000000514.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPregnancy-associated strokeStroke prevention strategiesPrevention strategiesPrimary stroke prevention strategiesMultidisciplinary rehabilitation teamLife-threatening complicationsScientific statementPregnancy-related strokeAcute strokeRisk factor modificationSecondary stroke prevention strategiesMaternal-fetal medicine specialistsAmerican Heart AssociationAcute stroke symptomsEvidence-based treatmentsRehabilitation teamPrompt treatmentLife-threatening complication of pregnancyPostpartum recoveryStroke risk assessmentPersistent disparitiesStroke hospitalizationsCesarean deliveryVaginal deliveryNeurological care
2025
Postdural puncture headache in obstetrics: revisiting long-term outcomes while reframing risk, consent, and postpartum follow-up
Delgado C, Leffert L. Postdural puncture headache in obstetrics: revisiting long-term outcomes while reframing risk, consent, and postpartum follow-up. International Journal Of Obstetric Anesthesia 2025, 65: 104813. PMID: 41192040, DOI: 10.1016/j.ijoa.2025.104813.Commentaries, Editorials and LettersObstetric Anesthesia at a Crossroads: Reflections on a 40-year Workforce Survey
Lim G, Leffert L. Obstetric Anesthesia at a Crossroads: Reflections on a 40-year Workforce Survey. Anesthesiology 2025, 143: 255-257. PMID: 40626743, PMCID: PMC12240461, DOI: 10.1097/aln.0000000000005576.Commentaries, Editorials and LettersResponse to: “Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)” by Kopp et al
Kopp S, Vandermeulen E, McBane R, Perlas A, Leffert L, Horlocker T. Response to: “Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)” by Kopp et al. Regional Anesthesia & Pain Medicine 2025, rapm-2025-106881. PMID: 40484652, DOI: 10.1136/rapm-2025-106881.Commentaries, Editorials and LettersEvidence-Based Clinical Practice Guidelines on Postdural Puncture Headache: A Consensus Report From a Multisociety International Working Group
Uppal V, Russell R, Sondekoppam R, Ansari J, Baber Z, Chen Y, DelPizzo K, Dirzu D, Kalagara H, Kissoon N, Kranz P, Leffert L, Lim G, Lobo C, Lucas D, Moka E, Rodriguez, Sehmbi H, Vallejo M, Volk T, Narouze S. Evidence-Based Clinical Practice Guidelines on Postdural Puncture Headache: A Consensus Report From a Multisociety International Working Group. Obstetric Anesthesia Digest 2025, 45: 61-63. DOI: 10.1097/01.aoa.0001113000.54578.7c.Peer-Reviewed Original ResearchPostdural puncture headacheEvidence-based clinical practice guidelinesPuncture headacheClinical questionsManagement of postdural puncture headacheClinical practice guidelinesSpinal anesthesia administrationPrevention of postdural puncture headacheInternational Working GroupMedical careMedical specialtiesPractice guidelinesComplication of dural punctureDaily activitiesDural punctureLiterature searchWorking GroupConsensus reportPreventionAnesthesia administrationGuidelinesHeadacheCareMultisocietySpecialtyRegional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)
Kopp S, Vandermeulen E, McBane R, Perlas A, Leffert L, Horlocker T. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition). Regional Anesthesia & Pain Medicine 2025, rapm-2024-105766. PMID: 39880411, DOI: 10.1136/rapm-2024-105766.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAmerican Society of Regional AnesthesiaDeep venous thrombosisEvidence-based guidelinesRegional anesthesiaThrombolytic therapyComplications associated with regional anesthesiaRecurrent deep venous thrombosisAmerican SocietyRandomized Controlled TrialsAnticoagulant doseNeural blockadeVenous thrombosisCase seriesCatastrophic complicationPatient characteristicsClinical trialsHigh dosesPatientsPublished guidelinesControlled TrialsPainAnesthesiaPatient safetyTherapyDose