2022
The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States
Katz D, Bateman B, Kjaer K, Turner D, Spence N, Habib A, George R, Toledano R, Grant G, Madden H, Butwick A, Lynde G, Minehart R, Beilin Y, Houle T, Sharpe E, Kodali B, Bharadwaj S, Farber M, Palanisamy A, Prabhu M, Gonzales N, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Obstetric Anesthesia Digest 2022, 42: 27-28. DOI: 10.1097/01.aoa.0000816828.87126.61.Peer-Reviewed Original Research
2020
Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study
Bauer M, Housey M, Bauer S, Behrmann S, Chau A, Clancy C, Clark E, Einav S, Langen E, Leffert L, Lin S, Madapu M, Maile M, McQuaid-Hanson E, Priessnitz K, Sela H, Shah A, Sobolewski P, Toledo P, Tsen L, Bateman B. Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study. Obstetric Anesthesia Digest 2020, 40: 65-66. DOI: 10.1097/01.aoa.0000661332.57510.93.Peer-Reviewed Original ResearchMulticenter case-control studyCase-control studyMaternal sepsisQuick Sequential Organ Failure Assessment criteriaSequential Organ Failure Assessment criteriaSystemic inflammatory response syndrome criteriaPregnancy-related deathsSigns of sepsisMaternal morbidityMaternal outcomesSyndrome criteriaPrompt treatmentPregnant womenEarly sepsisRisk factorsSepsisEarly identificationDifferent screening methodsPregnancyScreening toolScreening criteriaPhysiological changesPrimary objectiveScreening methodHospitalizationStroke in Pregnancy: A Focused Update.
Miller EC, Leffert L. Stroke in Pregnancy: A Focused Update. Anesthesia & Analgesia 2020, 130: 1085-1096. PMID: 31124843, PMCID: PMC7035913, DOI: 10.1213/ane.0000000000004203.Peer-Reviewed Original ResearchConceptsHemorrhagic strokeCesarean deliveryPregnant womenIschemic strokeGeneral anesthesiaObstetric anesthesiologistHigh-risk obstetriciansLarge stroke trialsPregnancy-related strokeHigh-risk groupRisk of herniationMaternal strokeObstetric indicationsTherapeutic anticoagulationExtremity weaknessStroke neurologistsAcute strokeDevastating complicationNeuraxial analgesiaNonpregnant womenStroke subtypesIntracranial hypertensionRecent strokeVaginal deliveryStroke trials
2018
Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy
Ladhani NNN, Swartz RH, Foley N, Nerenberg K, Smith EE, Gubitz G, Dowlatshahi D, Potts J, Ray JG, Barrett J, Bushnell C, Bal S, Chan WS, Chari R, Amrani M, Gandhi S, Hill MD, James A, Jeerakathil T, Jin A, Kirton A, Lanthier S, Lausman A, Leffert LR, Mandzia J, Menon B, Pikula A, Poppe A, Saposnik G, Sharma M, Bhogal S, Smitko E, Lindsay MP. Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy. International Journal Of Stroke 2018, 13: 743-758. PMID: 30021491, DOI: 10.1177/1747493018786617.Peer-Reviewed Original ResearchConceptsAcute stroke managementStroke managementConsensus statementPost-stroke managementSecondary stroke preventionAcute stroke treatmentGroup of patientsInitial emergency managementBest available literatureStroke preventionAcute strokePostpartum managementAnesthetic managementHemorrhagic strokeStroke treatmentObstetric carePregnant womenMaternal healthPrior historyClinical considerationsConsensus documentPregnancyExpert consensusStrokeHealthcare professionalsThe Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants
Leffert L, Butwick A, Carvalho B, Arendt K, Bates SM, Friedman A, Horlocker T, Houle T, Landau R, Dubois H, Fernando R, Houle T, Kopp S, Montgomery D, Pellegrini J, Smiley R, Toledo P. The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesthesia & Analgesia 2018, 126: 928-944. PMID: 29099429, DOI: 10.1213/ane.0000000000002530.Peer-Reviewed Original ResearchConceptsHigh-dose anticoagulantsConsensus statementMaternal deathsObstetric anesthesiaNeuraxial proceduresPerinatology Consensus StatementPharmacodynamics of anticoagulantsUse of thromboprophylaxisRisk-benefit discussionsKey preventive measuresObstetric populationObstetric surgeryCesarean deliveryNeuraxial analgesiaVenous thromboembolismAnesthetic managementObstetric patientsDifficult airwayNeuraxial anesthesiaGeneral anesthesiaPostpartum womenPregnant womenFetal harmPostpartum periodLeading causeNeuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low–Molecular-Weight Heparin
Leffert L, Dubois H, Butwick A, Carvalho B, Houle T, Landau R. Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low–Molecular-Weight Heparin. Obstetric Anesthesia Digest 2018, 38: 3-4. DOI: 10.1097/01.aoa.0000529964.63597.d5.Peer-Reviewed Original ResearchSpinal epidural hematomaObstetric patientsNeuraxial anesthesiaWeight heparinVenous thromboembolismCesarean deliveryEpidural hematomaPregnant womenNeuraxial blockadeNational guidelinesPatientsThromboprophylaxisHeparinAnesthesiaSafe useWomenLow-MolecularThromboembolismHematomaBlockadeReview reportsPresent review reports
2014
Opioid Abuse and Dependence during Pregnancy
Maeda A, Bateman BT, Clancy CR, Creanga AA, Leffert LR. Opioid Abuse and Dependence during Pregnancy. Anesthesiology 2014, 121: 1158-1165. PMID: 25405293, DOI: 10.1097/aln.0000000000000472.Peer-Reviewed Original ResearchConceptsOpioid abuseObstetrical outcomesIntrauterine growth restrictionNationwide Inpatient SampleObstetrical morbidityPlacental abruptionPreterm laborCesarean deliveryMaternal deathsPremature rupturePregnant womenCardiac arrestRelevant confoundersInpatient SampleGrowth restrictionPreventive strategiesTherapeutic interventionsPregnancyLogistic regressionNationwide trendsHospitalizationPrevalenceAbuseOutcomesUnited States
2013
Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers
Jones HE, Deppen K, Hudak ML, Leffert L, McClelland C, Sahin L, Starer J, Terplan M, Thorp JM, Walsh J, Creanga AA. Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers. American Journal Of Obstetrics And Gynecology 2013, 210: 302-310. PMID: 24120973, PMCID: PMC7213596, DOI: 10.1016/j.ajog.2013.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineConfidentialityDose-Response Relationship, DrugEmergency Service, HospitalFemaleHumansLabor PainLabor, ObstetricMental DisordersMethadoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPain, PostoperativePhysician-Patient RelationsPostnatal CarePregnancyPregnancy ComplicationsPrenatal CareReferral and ConsultationTriageConceptsPregnant womenObstetric providersPostpartum periodPregnant patientsMixed opioid agonist/antagonistOpioid-dependent pregnant patientsOpioid-dependent pregnant womenOpioid agonist/antagonistHigh-quality obstetric careMedication-assisted withdrawalTherapeutic opioid useAcute pain managementHigh relapse rateDrug use disordersClinical care issuesIntense medical careBest possible outcomeOpioid withdrawalOpioid usePain managementRelapse rateObstetric carePostpartum womenComprehensive careClinical care
2012
Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study
Terry AR, Barker FG, Leffert L, Bateman BT, Souter I, Plotkin SR. Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study. Neuro-Oncology 2012, 14: 768-776. PMID: 22513749, PMCID: PMC3367848, DOI: 10.1093/neuonc/nos078.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBostonBrain NeoplasmsCesarean SectionChildDelivery, ObstetricFemaleFetal Growth RetardationFollow-Up StudiesHospitalizationHumansMaternal MortalityObstetric Labor, PrematurePregnancyPregnancy Complications, NeoplasticPregnancy OutcomeRetrospective StudiesRisk FactorsSpinal NeoplasmsSurvival RateYoung AdultConceptsBenign brain tumorsIntrauterine growth restrictionMalignant brain tumorsNationwide Inpatient SamplePopulation-based studyCNS neoplasmsBrain tumorsCaesarean deliveryPreterm laborSpine tumorsPregnancy outcomesMaternal mortalityPregnancy-related admissionsAdverse pregnancy outcomesRetrospective cohort studyOutcomes of hospitalizationLogistic regression modelsPregnancy complicationsCohort studyHyperemesis gravidarumSurgical patientsObstetric riskPregnant womenInpatient SampleGrowth restriction
2011
Influence of Patient Comorbidities on the Risk of Near-miss Maternal Morbidity or Mortality
Mhyre J, Bateman B, Leffert L. Influence of Patient Comorbidities on the Risk of Near-miss Maternal Morbidity or Mortality. Anesthesiology 2011, 115: 963-972. PMID: 21934482, DOI: 10.1097/aln.0b013e318233042d.Peer-Reviewed Original ResearchConceptsNear-miss morbidityMorbidity/mortalityMaternal morbidityNear-miss maternal morbidityImportant medical comorbiditiesEnd-organ injuryHigh-quality intrapartum careSystemic lupus erythematosusNationwide Inpatient SampleHigh-risk groupLength of stayMiss morbidityMedical comorbiditiesObstetric complicationsPulmonary hypertensionPatient comorbiditiesLupus erythematosusIntrapartum carePregnant womenNational burdenInpatient SampleMaternal characteristicsObstetric diseasesPublic health investmentDelivery outcomes