2017
Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency
Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A. Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency. Scientific Reports 2017, 7: 15386. PMID: 29133876, PMCID: PMC5684317, DOI: 10.1038/s41598-017-13071-2.Peer-Reviewed Original ResearchConceptsEphrin-B2/FcVenous remodelingAVF maturationFistula patencyEph-B4Knockout miceMouse aortocaval fistula modelAkt1 knockout miceArteriovenous fistula patencyAortocaval fistula modelArteriovenous fistula maturationFistula environmentFistula useFistula veinAVF patencyFistula diameterFistula maturationVenous adaptationFistula modelWall thicknessPatencyProtein expressionAKT1 expressionEphrin-B2Lower rates
2016
Future research directions to improve fistula maturation and reduce access failure
Hu H, Patel S, Hanisch JJ, Santana JM, Hashimoto T, Bai H, Kudze T, Foster TR, Guo J, Yatsula B, Tsui J, Dardik A. Future research directions to improve fistula maturation and reduce access failure. Seminars In Vascular Surgery 2016, 29: 153-171. PMID: 28779782, PMCID: PMC5547899, DOI: 10.1053/j.semvascsurg.2016.08.005.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaAVF maturationAVF failurePatient selectionNeointimal hyperplasiaAccess failureEnd-stage renal diseaseDrastic hemodynamic changesSetting of uremiaAppropriate patient selectionCareful patient selectionNovel interventional techniquesVascular cell activationAlternative surgical strategiesPatient-specific outcomesFistula useSystemic inflammationRenal diseaseFistula maturationInflammatory mediatorsHemodynamic changesSurgical strategyVascular accessSpecific therapyFistula anastomosis