2017
Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?
Isaji T, Hashimoto T, Yamamoto K, Santana JM, Yatsula B, Hu H, Bai H, Jianming G, Kudze T, Nishibe T, Dardik A. Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries? Annals Of Vascular Diseases 2017, 10: ra.17-00008. PMID: 29034014, PMCID: PMC5579803, DOI: 10.3400/avd.ra.17-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial nitric oxide synthaseVein graftsVein graft failureGraft failureEph-B4Endothelial cellsCritical limb ischemiaAutogenous vein graftsNitric oxide synthaseGold standard conduitNovel therapeutic targetMouse vein graftsVein graft wallExcessive neointimal hyperplasiaVein graft adaptationVenous endothelial cellsPREVENT trialArterial environmentGraft outcomeLimb ischemiaAdequate dilationArterial bypassOxide synthaseVascular surgeonsNeointimal hyperplasia
2016
Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase
Wang M, Collins MJ, Foster TR, Bai H, Hashimoto T, Santana JM, Shu C, Dardik A. Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase. Journal Of Vascular Surgery 2016, 65: 179-189. PMID: 26817610, PMCID: PMC4958608, DOI: 10.1016/j.jvs.2015.11.041.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell MovementCells, CulturedEnzyme InhibitorsEphrin-B2GenotypeHumansMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIIPhenotypePhosphorylationReceptor, EphB4Saphenous VeinSignal TransductionTime FactorsVascular RemodelingVena Cava, InferiorConceptsEndothelial nitric oxide synthaseEphrin-B2/FcVein graft adaptationENOS knockout miceNitric oxide synthaseVein graftsGraft adaptationENOS phosphorylationENOS activityEph-B4Oxide synthaseKnockout miceWild-type vein graftsVessel remodelingWestern blotLess wall thickeningArginine methyl ester hydrochlorideMouse vein graftsNitric oxide productionLung endothelial cellsMouse lung endothelial cellsCell migrationLigand ephrin-B2Mechanism of actionMethyl ester hydrochloride