2019
Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency
Hashimoto T, Isaji T, Hu H, Yamamoto K, Bai H, Santana JM, Kuo A, Kuwahara G, Foster TR, Hanisch JJ, Yatsula BA, Sessa WC, Hoshina K, Dardik A. Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 754-764. PMID: 30786746, PMCID: PMC6436985, DOI: 10.1161/atvbaha.119.312417.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, AbdominalArteriovenous Shunt, SurgicalCaveolaeCaveolin 1Cells, CulturedDrug Evaluation, PreclinicalHemorheologyHumansLungMaleMiceMice, Inbred C57BLMice, KnockoutNitric OxideNitric Oxide Synthase Type IIIPeptide FragmentsReceptor, EphB4Signal TransductionVascular RemodelingVena Cava, InferiorConceptsCav-1 KO miceAVF maturationWT miceAVF patencyEph-B4KO miceCav-1 functionCav-1Mouse aortocaval fistula modelEphrin-B2/FcArteriovenous fistula patencyAortocaval fistula modelCaveolin-1 SignalingFistula environmentCav-1 mRNAFistula patencyHET miceVenous adaptationEndothelial cell membraneENOS activityFistula modelRC miceControl veinsWall thickeningMice
2017
Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency
Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A. Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency. Scientific Reports 2017, 7: 15386. PMID: 29133876, PMCID: PMC5684317, DOI: 10.1038/s41598-017-13071-2.Peer-Reviewed Original ResearchConceptsEphrin-B2/FcVenous remodelingAVF maturationFistula patencyEph-B4Knockout miceMouse aortocaval fistula modelAkt1 knockout miceArteriovenous fistula patencyAortocaval fistula modelArteriovenous fistula maturationFistula environmentFistula useFistula veinAVF patencyFistula diameterFistula maturationVenous adaptationFistula modelWall thicknessPatencyProtein expressionAKT1 expressionEphrin-B2Lower ratesImproving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?
Isaji T, Hashimoto T, Yamamoto K, Santana JM, Yatsula B, Hu H, Bai H, Jianming G, Kudze T, Nishibe T, Dardik A. Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries? Annals Of Vascular Diseases 2017, 10: ra.17-00008. PMID: 29034014, PMCID: PMC5579803, DOI: 10.3400/avd.ra.17-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial nitric oxide synthaseVein graftsVein graft failureGraft failureEph-B4Endothelial cellsCritical limb ischemiaAutogenous vein graftsNitric oxide synthaseGold standard conduitNovel therapeutic targetMouse vein graftsVein graft wallExcessive neointimal hyperplasiaVein graft adaptationVenous endothelial cellsPREVENT trialArterial environmentGraft outcomeLimb ischemiaAdequate dilationArterial bypassOxide synthaseVascular surgeonsNeointimal hyperplasia
2016
Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase
Wang M, Collins MJ, Foster TR, Bai H, Hashimoto T, Santana JM, Shu C, Dardik A. Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase. Journal Of Vascular Surgery 2016, 65: 179-189. PMID: 26817610, PMCID: PMC4958608, DOI: 10.1016/j.jvs.2015.11.041.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell MovementCells, CulturedEnzyme InhibitorsEphrin-B2GenotypeHumansMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIIPhenotypePhosphorylationReceptor, EphB4Saphenous VeinSignal TransductionTime FactorsVascular RemodelingVena Cava, InferiorConceptsEndothelial nitric oxide synthaseEphrin-B2/FcVein graft adaptationENOS knockout miceNitric oxide synthaseVein graftsGraft adaptationENOS phosphorylationENOS activityEph-B4Oxide synthaseKnockout miceWild-type vein graftsVessel remodelingWestern blotLess wall thickeningArginine methyl ester hydrochlorideMouse vein graftsNitric oxide productionLung endothelial cellsMouse lung endothelial cellsCell migrationLigand ephrin-B2Mechanism of actionMethyl ester hydrochloride