Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression
Luciano AK, Santana JM, Velazquez H, Sessa WC. Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. Journal Of Biological Rhythms 2017, 32: 212-221. PMID: 28452287, PMCID: PMC5703205, DOI: 10.1177/0748730417704534.Peer-Reviewed Original ResearchConceptsCircadian gene expressionCircadian regulatorsAmplitude of expressionGene expressionAkt isoformsIsoforms of AktCircadian transcriptionOrganismal levelPositive regulatorNormal behavioral rhythmsCircadian rhythmPeripheral clocksBehavioral rhythmsAKT1RegulatorAktIsoformsMammalsAmplitude rhythmsDaily rhythmsDifferent functionsLow-amplitude rhythmExpressionEndothelial cellsMice exhibitImproving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?
Isaji T, Hashimoto T, Yamamoto K, Santana JM, Yatsula B, Hu H, Bai H, Jianming G, Kudze T, Nishibe T, Dardik A. Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries? Annals Of Vascular Diseases 2017, 10: ra.17-00008. PMID: 29034014, PMCID: PMC5579803, DOI: 10.3400/avd.ra.17-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial nitric oxide synthaseVein graftsVein graft failureGraft failureEph-B4Endothelial cellsCritical limb ischemiaAutogenous vein graftsNitric oxide synthaseGold standard conduitNovel therapeutic targetMouse vein graftsVein graft wallExcessive neointimal hyperplasiaVein graft adaptationVenous endothelial cellsPREVENT trialArterial environmentGraft outcomeLimb ischemiaAdequate dilationArterial bypassOxide synthaseVascular surgeonsNeointimal hyperplasia