Martin A Schwartz, PhD

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Biomedical Engineering and of Cell Biology

Departments & Organizations

Internal Medicine: Cardiovascular Medicine: Yale Cardiovascular Research Center: Schwartz Lab

Cell Biology

Faculty Research

Vascular Biology and Therapeutics Program

Yale Cancer Center

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Human Disease; Molecular Mechanisms; Signal Transduction

Biography

Martin Schwartz earned a BA in chemistry from New College in Sarasota FL and a PhD in physical chemistry from Stanford, where he worked in Harden McConnell’s lab on biophysics of phospholipid membranes.He then did postdoctoral research in biology at MIT in the laboratory of Richard Hynes where he studied interactions of fibronectin with cells and other proteins. He was on the faculty at Harvard Medical School, Scripps Research Institute and the University of Virginia prior to moving to Yale in 2011. Starting in the 1980’s, his lab was among the first to report that integrin mediated adhesion could regulate signaling pathways in cells;that integrin-mediated adhesion promotes cell survival, that integrins synergize with growth factor receptors to activate growth signaling pathways and that integrins regulate Rho family GTPases. His lab has also elucidated mechanotransduction pathways by which endothelial cells respond to fluid shear stress to activate inflammatory pathways linked to atherosclerosis. His current research program combines studies using biophysical, cellular and animal approaches to important questions about integrin signaling, mechanotransduction and disease in the vascular system.

Education & Training

PhD Stanford University (1979)
BA New College of the University South Florida (1975)
Postdoctoral fellow MIT

Honors & Recognition

  • Harold F. Dvorak Plenary Lecture Harvard Medical School (2013)

  • Andrew P. Somlyo Honorary LecturePennsylvania Muscle Institute, University of Pennsylvania (2013)

  • Robert W. Berliner Professor of MedicineYale School of Medicine (2012)

  • Hayashi Lecturer, Woods Hole MBL Physiology CourseMarine Biology Laboratory (2009)

  • James O. Davis LectureshipUniversity of Missouri (2009)

Professional Service

  • Gordon Research Conference, Signaling by Cell Adhesion Receptor (2012 - 2012) Chair

  • Frontiers in Cell Migration & Mechanotransduction (2011 - 2011) Co-Chair

  • Gordon Research Conference, Vascular Cell Biology (2011 - 2011) Chair

  • Mechanotransduction in Physiology and Disease (2009 - 2009) Chair (with Alpha Yap and Chris Chen, co-chairs)

  • Keystone conference on Signaling by Integrins and Growth Factor Receptors (1998 - 1998) Chair (with Lewis Cantley, co-chair)

  • Keystone conference on Integrins and Signaling Events in Cell Biology and Disease (1996 - 1996) Co-chair (with David Cheresh, chair)

  • Matrix Biology (1997-2012) Editorial Board Member

  • Journal of Cell Biology (2001-present) Associate Editor

  • Journal of Cell Science (2006-present) Editorial Board Member

  • Biochemical Journal (2006-2008) Editorial Board Member

  • Biochemical Journal (2008-present) Deputy Editor

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Contact Info

Martin A Schwartz, PhD

Curriculum Vitae

The Schwartz Lab

Reduced atherosclerosis in integrin mutant mice