Albert John Sinusas, MD

Professor of Medicine (Cardiology) and of Diagnostic Radiology; Director, Translational Research Imaging Center; Director, Cardiovascular Imaging

Research Interests

Research Organizations

Diagnostic Radiology: Bioimaging Sciences | Clinical Radiology

Internal Medicine: Cardiovascular Medicine: Yale Translational Research Imaging Center (Y-TRIC) | Diabetes Research Center

Vascular Biology and Therapeutics Program

Research Summary

My research is directed at development of noninvasive imaging approaches for the assessment of myocardial viability, angiogenesis, and post–infarction remodeling. This translational research employs the 3–D modalities of SPECT, PET, echocardiography and MR imaging for assessment of regional myocardial perfusion, function and metabolism, in an animal physiology laboratory, employing large and small animal models of myocardial ischemia and infarction, and peripheral arterial disease. My laboratory is currently focused on targeted molecular imaging, developing non–invasive nuclear imaging strategies for identifying the hypoxic stimulus for angiogenesis, and targeted imaging of selected integrins previously established to modulate the angiogenic process, and evaluation of the role of matrix metalloproteinases on post–infarction remodeling. The investigation of these biological processes involves, in vitro cellular and whole heart preparations, as well as ex vivo and in vivo imaging in both small and large animal models, using dedicated high–resolution and real–time 3D ultrasound imaging, hybrid SPECT–CT and PET–CT imaging, cardiac MR imaging, and fluorescent imaging systems.

Selected Publications

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Contact Info

Albert John Sinusas, MD
Patient Care Locations
Yale CardiologyYale-New Haven Shoreline Medical Center
111 Goose Lane, Ste 2nd Floor

Guilford, CT 06437
Yale-New Haven Hospital
20 York Street

New Haven, CT 06510
Office Location
Clinic Building
789 Howard Avenue, Ste 5029

New Haven, CT 06519
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056

Yale Translational Research Imaging Center (Y-TRIC)