Stephanie Halene MD, PhD

Assistant Professor of Medicine (Hematology)

Research Interests

Hematopoiesis; Myeloid differentiation; Leukemia; Myelodysplasia

Research Summary

Dr. Halene's laboratory studies hematopoiesis and myelopoiesis and in particular how abnormalities of the hematopoietic stem and progenitor cells lead to diseases with abnormal numbers and function of blood cells. The laboratory uses primary patient cells and murine models to study mechanisms of disease leading to myelodysplasia and acute myeloid leukemia with the ultimate goal to contribute to the development of novel treatments.

Selected Publications

  • Smith, E.C., Thon, J.N., Devine, M.T., Massaro, S.A., Lin, S., Halene, S., Italiano Jr., J.E., Krause, D.S. MKL1 and MKL2 Play Redundant and Crucial Roles in Megakaryocyte Maturation and Platelet Formation. Blood 2012 Jul 17. Epub ahead of print
  • Liu, J., Halene, S., Yang, M., Iqbal, J., Yuen, T., Mehal, W.Z., Chuang, W.L., Jain, D., Sun, L., Zaidi, M., Mistry, P.K. The Gaucher Disease Gene GBA1 Functions in Immune Regulation. Proc Natl Acad Sci USA 2012;109(25): 10018-23.
  • Halene S, Gao Y, Hahn K, Massaro S, Lin S, Krause DS. Serum Response Factor (SRF) is an essential transcription factor in megakaryocytic maturation. Blood 2010 Sep 16; 116(11):1828-9. Epub 2010 Jun 4.
  • Gao Y, Smith E, Ker DE, Campbell P, Cheng E, Zhou S, Lin S, Wang L, Halene S, Krause DS. Role of RhoA Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes. Dev Cell. 2012 Mar 13;22(3):573-84. Epub 2012 Mar 1
  • Halene S, Gaines P, Sun H, Zibello T, Lin S, Khanna-Gupta A, Williams SC, Perkins A, Krause DS, Berliner N. C/EBPepsilon directs granulocytic versus monocytic lineage determination and confers chemotactic function via Hlx. Experimental Hematology, 2010 Feb;38(2):90-103. PMCID: PMC2827304
  • Zhang Y, Tang W, Jones MC, Xu W, Halene S, and Wu D Different roles of Gß1 and Gß2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils J. Biol. Chem. 2010 Aug 6;285(32):24805-14. Epub 2010 Jun 4.
  • Halene S., A. Zieske, Berliner N. Sustained remission from angioimmunoblastic T-cell lymphoma induced by alemtuzumab." Nat Clin Pract Oncol. 3(3): 165-8, 2006
  • Halene S, Kohn DB. Gene Therapy Using Hematopoietic Stem Cells: Sisyphus Approaches the Crest. Human Gen Therapy 11(9): 1259-67, 2000. PMID: 10890736
  • Halene S, Wang L, Cooper RM, Bockstoce D, Robbins PB, Kohn DB. Improved Expression in Hematopoietic and Lymphoid Cells in Mice after Transplantation of Bone Marrow Transduced with a Modified Retroviral Vector. Blood, Vol 94 (10): 3349-3357, 1999. PMID: 10552944

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