Neurological disorders affect millions of people worldwide, and health care costs related to treating these illnesses are enormous. They include a broad spectrum of brain problems such as birth defects, mental retardation, neuropsychiatric disorders, and neurodegenerative diseases.
The overall goal of my laboratory is to better understand the fundamental mechanisms of neural development and function, as well as its relevance to the pathogenesis of diverse human neurological disorders. The lab is currently focused on two major questions. First, what is the molecular and cellular basis of neurodegenerative diseases? Second, how is neurogenesis regulated during embryonic and adult stages and how does its malfunction contribute to neurological problems?
To achieve this goal, we utilize the combined approaches of biochemistry, cell biology, behavior, and molecular genetics with in vivo animal (e.g. Drosophila and mouse) models.
Extensive Research Description
Pathogenesis studies (molecular and cellular basis) of neurodegenerative diseases
- Ju H, Kokubu H, Todd TW, Kahle JJ, Kim S, Richman R, Chirala K, Orr HT, Zoghbi HY, and Lim J. (2013). Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. Journal of Neuroscience 33, 9328-9336.
- Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, and Zoghbi HY. (2008). Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature 452, 713-718.
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual J-F, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási A-L, Vidal M, and Zoghbi HY. (2006). A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125, 80