Adolescent Psychiatry; Bipolar Disorder; Child Psychiatry; Depression; Magnetic Resonance Imaging; Psychiatry; Suicide; Mood Disorders; Diffusion Tensor Imaging; Neuropsychiatry
Psychiatry: Neuroscience Research Training Program (NRTP) | Psychotherapy Development Center | Stress & Addiction Clinical Research Program | Women's Behavioral Health Research, Division of | Yale Mood Disorders Research Program
Obesity Research Working Group
A focus of Dr. Blumberg's laboratory is the use of brain scanning techniques to elucidate the differences in brain circuitry that underlie mood disorders, and how these differences develop in children and adolescence and change over the lifespan into later life. The laboratory has identified differences in parts of the brain that are important in emotional regulation in bipolar disorder, including differences in the pattern of their development in the disorder. For example, the laboratory has identified amygdala differences that are present in adults with bipolar disorder and also in adolescents with bipolar disorder suggesting that these are features that appear early, at least by adolescence in the disorder. Differences in the ventral prefrontal cortex (a part of the brain that includes the orbitofrontal cortex, the part of the prefrontal cortex above the eyes) appear to progress over the course of adolescence in bipolar disorder. This suggests that early intervention might be able to prevent progression and help prognosis. Recently, they identified brain circuitry differences in adolescents and young adults who made suicide attempts. Preliminary evidence suggests treatment may reverse some of the brain differences and may have the potential to prevent mood disorder progression and suicide.
The lab is working intensively on genetic and environmental factors that may contribute to the brain differences and that may point to new prevention and treatment strategies. Brain scanning techniques used in this work include structural magnetic resonance imaging (MRI) to study the size and shape of brain structures (including cutting edge new methods with 7 Tesla MRI scanning), functional magnetic resonance imaging (fMRI) to study how the parts of the brain function individually and as part of brain circuits, and diffusion tensor imaging (DTI) to study the connections between brain structures.
Specialized Terms: Adolescence; Bipolar Disorder; Brain; Depression; Suicide; Development; Diffusion Tensor Imaging; Emotion; Endophenotype; Functional Magnetic Resonance Imaging; Magnetic Resonance Imaging; Mania; Manic Depressive Disorder; Neuropsychiatry; Neuroscience; Women
Extensive Research Description
Dr. Blumberg is the Director of The Yale Mood Disorders Research Program (MDRP). The MDRP is dedicated to understanding the science of mood disorders, including bipolar disorder (manic-depressive illness) and depression. The MDRP brings together a multi-disciplinary group of scientists from across the Yale campus in a highly collaborative research effort. The scientists use a wide variety of scientific methods to study how genetic and environmental factors affect the brain and influence the expression of mood disorders across the lifespan. Goals of the MDRP include the identification of biological markers for mood and related disorders and discovery of new treatment strategies. It is hoped that these research efforts will lead to new and improved methods for early detection and treatment, and someday prevention, of mood disorders and suicide.
- MRI Brain Scanning Studies of Adolescents and Adults with Bipolar Disorder and Depression
- MRI Brain Scanning Studies of Brain Development in Healthy Adolescents and Adults
- MRI Brain Scanning Studies of Youths At-Risk for Bipolar Disorder
- MRI and Gene Studies of Genes and the Brain
- MRI Study of Stress Effects on the Brain and Development of Mood and Substance Use Disorders
- MRI methods include: structural MRI, functional MRI, diffusion tensor imaging, and structural MRI and magnetic resonance imaging at 7 Tesla.
- Development of Novel Medication and Non-Medication Interventions to Reduce and Prevent Symptoms and Suicide
Multimodal imaging of fronto-limbic structure and function associated with suicide attempts in adolescents and young adults with bipolar disorder
Johnston, J.A.Y, F. Wang, J. Liu, B. Blond, A. Wallace, J. Liu, L. Spencer, E.T. C. Lippard, Purves, K.L., A. Landeros-Weisenberger, E. Hermes, B. Pittman, R. King, A. Martin, M. Oquendo, H.P. Blumberg. American Journal of Psychiatry, 2017, Jan 31:appiajp 201615050652. doi:10.1176/appi.ajp. 2016.15050652. [Epub ahead of print]
Effects of ANK3 variation on gray and white matter in bipolar disorder
Lippard, E.T.C., K.P. Jensen, F. Wang, J.A.Y. Johnston, L. Spencer, B. Pittman, J. Gelernter, H.P. Blumberg. Molecular Psychiatry, 2016 May 31. doi: 10.1038/mp.2016.76. [Epub ahead of print]
Anterior cortical development during adolescence in bipolar disorder
Najt, P., F. Wang, L. Spencer, J.A.Y. Johnston, E.T. Cox Lippard, B.P. Pittman, C. Lacadie, L.H. Staib, X. Papademetris, H.P. Blumberg. Biological Psychiatry. 2016, 79:303-310.
Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment
Edmiston, E.E., F. Wang, C.M. Mazure, J. Guiney, R. Sinha, L.C. Mayes, H.P. Blumberg. Archives of Pediatrics and Adolescent Medicine. 2011, 165:1069-1077.
Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder
Wang, F., J.H. Kalmar, F.Y. Womer, E.E. Edmiston, L.G. Chepenik, B. R. Chen, L. Spencer, H.P. Blumberg. Brain. 2011, 134:2005-2012.
Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder
Wang, F., J.H. Kalmar, Y. He, M. Jackowski, L.G. Chepenik, E.E. Edmiston, K. Tie, G. Gong, M.P. Shah, M. Jones, J. Uderman, R.T. Constable, H.P. Blumberg. Biological Psychiatry. 2009, 66:516-521.
- Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study Blumberg, H.P., J.H. Krystal, R. Bansal, A. Martin, J. Dziura, K. Durkin, L. Martin, E. Gerard, D.S. Charney, B.S. Peterson. Biological Psychiatry. 2006, 59:611-618.
Amygdala and hippocampus volumes in adolescents and adults with bipolar disorder.
Blumberg HP, Kaufman J, Martin A, Whiteman R, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and hippocampus volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry 2003;60:1201-1208
A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices.
Blumberg HP, Leung HC, Skudlarski P, Lacadie C, Fredericks C, Harris B, Charney D, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry 2003;60: 599-607.
- Rostral and orbital prefrontal dysfunction in the manic state of bipolar disorder Blumberg, H.P., E. Stern, S. Ricketts, D. Martinez, J. de Asis, T. White, J. Epstein, N. Isenberg, P.A. McBride, I. Kemperman, S. Emmerich, V. Dhawan, D. Eidelberg, J.H. Kocsis, D.A. Silbersweig. American Journal of Psychiatry. 1999, 156:1986-1988.