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Horvath Laboratory

The major goal of this laboratory is to determine the signaling flow and regulatory relationship within and between neuronal circuits that underlie the maintenance of physiological and pathological homeostatic conditions with particular emphasis on metabolic disorders, such as obesity, diabetes, neurodegeneration and aging. We focus on key hypothalamic neural circuits that govern and determine peripheral tissue functions and associated motivated behaviors. The laboratory utilizes contemporary tools of genetics, biochemistry, molecular biology, cell- and neurobiology, physiology and motivated behavior.