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Faculty

  • Waldemar Von Zedtwitz Professor of Comparative Medicine and of Immunobiology

    Vishwa Deep Dixit completed Bachelor and Master of Veterinary Sciences in HAU, Hisar India. He received German Academic Exchange Service fellowship to conduct PhD research in Germany. He completed PhD coursework in HAU and Research Work in University of Hannover in Year 2000. He conducted postdoctoral research training in NIH. He joined Pennington Biomedical Research Center as an Assistant Professor in 2006 and moved to Yale as Professor of Comparative Medicine and Immunobiology in 2013. Dixit’s research is focused on understanding the interactions between metabolic and immune systems with the goal to reveal molecular targets that can be harnessed to control inflammation and immune dysfunction as means to enhance the healthspan. The research in Dixit Laboratory is funded by the National Institutes of Health, Glenn Foundation for Aging Research and Cure for Alzheimer Foundation.

  • Anthony N. Brady Professor of Comparative Medicine and of Pathology

    Carlos studied Biochemistry and Molecular Biology at the Universidad Autonoma of Madrid. From 1999 to 2004, he performed his PhD with Prof. Miguel Angel Lasuncion at Hospital Ramon y Cajal (Madrid). He did his postdoctoral training with Prof. William Sessa at Yale University (2005-2009). Then, Carlos started his laboratory in the Department of Medicine at NYU. He is currently an Associate Professor in the Comparative Medicine Department and a Member of the Vascular Biology & Therapeutics Program

  • Senior Research Scientist

    Fascinated by how the brain controls complex physiological functions and behaviors in higher animals, Dr. Gao pursued his career in neurobiology under the mentorship of the renowned neurophysiologist Professor Te-Pei Feng (AKA T. P. Feng) at the Shanghai Institute of Physiology, Chinese Academy of Science, obtaining his PhD in 1996. In the fall of the same year, he joined Dr. Anthony van den Pol’s laboratory as postdoctoral associate in the Section of Neurosurgery at the Yale University School of Medicine.

    Trained as an electrophysiologist, Dr. Gao’s early interests laid in investigating the modulation of activity in developing and mature hypothalamic neurons by neurotransmitters, neuropeptides and neurotrophic factors. He is the first investigator to characterize the cellular functions of neuropeptides hypocretin/orexin and melanin-concentrating hormone (MCH) in nerve cells in the central nervous system (CNS). After establishing an independent research group at Yale, his current interests are to understand how biological processes at molecular, cellular and systems levels lead to the emergence of physiological functions (such as energy balance and sleep/wake regulation) and complex behaviors (such as reward seek/addiction, stress coping strategy and social behaviors) critical to animal survival. The group’s major discoveries provide first evidence that experience-dependent neural plasticity in neuronal systems (such as the hypocretinergic and MCHergic systems) in the lateral hypothalamus underlies promotion of positive energy balance and maintenance of wakefulness and arousal, which may contribute to the development of insomnia, drug addiction and obesity-associated behavioral changes in animals.  

  • Jean and David W. Wallace Professor of Comparative Medicine and Professor of Neuroscience and of Obstetrics, Gynecology, and Reproductive Sciences; Chair, Department of Comparative Medicine

    Tamas Horvath is Professor and Chair of the Department of Comparative Medicine and Professor of Neurobiology and Ob/Gyn at Yale University School of Medicine, New Haven, Connecticut. He is also the Director for the Yale Program on Integrative Cell Signaling and Neurobiology of Metabolism. He received a Doctor of Veterinary Medicine (D.V.M.) degree from the Faculty of Veterinary Sciences in Budapest, Hungary, and a Doctor of Philosophy (Ph.D.) degree from the University of Szeged in Hungary. His research has been focusing on neuronal circuitries that support physiological and pathological homeostatic conditions, including processes associated with reproduction, energy metabolism and neurodegeneration.

  • Professor, Obstetrics, Gynecology & Reproductive Sciences

    Dr. Yingqun Huang is Professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale University School of Medicine. She received her undergraduate and medical degree from Fudan University School of Medicine in 1988 and her Ph.D. in Biomedical Sciences from the University of Connecticut in 1997. She carried out postdoctoral work with Dr. Gordon Carmichael at the University of Connecticut Health Center and then with Dr. Joan Steitz at Yale University in the field of RNA and posttranscriptional regulation of gene expression in mammalian cells. She joined the faculty in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale in 2003 and was promoted to Professor in 2020. 

    Dr. Huang’s research centers on the mechanistic understanding of endocrine disorders including diabetes and infertility, in addition to reproductive tract tumors. In the past 7 years studies from her laboratory have demonstrated that noncoding RNAs play an important role in human health and disease and could constitute a novel class of RNA therapeutics for uterine fibroids, ovarian and endometrial cancers, and type-2 diabetes. Her significant contributions in the fields are highlighted by multiple publications in high impact journals, including Molecular CellNature CommunicationsEMBO Molecular MedicinePNASNucleic Acids ResearchCell ReportsDiabetes, and Oncogene

    In addition to research, Dr. Huang is a dedicated teacher and mentor. She has mentored and trained many medical fellows, postdoctoral associates, and PhD students. Two of the medical fellows have become reproductive physician scientists holding assistant professor positions. Dr. Huang has served as and will continue to be Director of Molecular Biology Core Training Laboratory for the Yale Women’s Reproductive Health Research program (WRHR). In recognition of her deep commitment to teaching and mentoring, she received the Harold Behrman Teaching Award in 2013.

     

     

     

     

     

     


  • Associate Professor of Medicine

    Dr. Kibbey obtained his undergraduate degrees in music (B.A.) and an honors degree in biochemistry (B.S.) at Trinity University in San Antonio in 1991. He then obtained his combined M.D. and Ph.D. at the University of Texas Southwestern Medical School in 2000. His Ph.D. was in Cellular and Molecular Biophysics and involved determining the NMR structure of peptides from the LDL receptor under his mentors Drs. R.G.W. Anderson and L. Gierasch. Subsequently, he went to Yale University in where he was selected for the ABIM short-track in Categorical Internal Medicine. In 2002 he stayed on for his Endocrinology fellowship at Yale and is now board certified in Internal Medicine and Endocrinology. While in his fellowship he worked in the laboratory of Dr. Gerald Shulman on metabolism in the pathophysiology of Type-2 Diabetes Mellitus. Here he identified mitochondrial GTP as a metabolic signal in the mitochondria sensing flux in the pancreatic beta-cell as a crucial component of the signal to secrete insulin. His laboratory also has developed a novel platform using stable isotopes and mass spectrometry named Mass Isotopomer MultiOrdinate Spectral Analysis (MIMOSA) that measures the flow of metabolism inside and between tissues. He is now an Associate Professor in the Departments of Internal Medicine/Endocrinology and Cellular & Molecular Physiology. He continues to see patients at Yale Health and has an independent NIH-supported laboratory doing research on islet and whole body physiology in order to understand/prevent/treat Type-2 diabetes.

  • Associate Professor and Vice Chair for Diversity, Inclusion and Equity at Comparative Medicine

    I am interested in the neural mechanisms underlying decision-making in humans, in individual differences in these mechanisms, and in the possible contribution of decision traits to pathological behavior. Our research focuses on decision-making under uncertainty, and on value learning and encoding. To study these topics we combine behavioral economics methods with functional MRI, as well as eye tracking and physiological measurements.

  • Assistant Professor

    Dr. Rachel Perry is an Assistant Professor in Medicine/Endocrinology and Cellular & Molecular Physiology at the Yale University School of Medicine. Rachel's background is in the use of hyperinsulinemic-euglycemic clamps and stable isotope infusions to assess insulin sensitivity, having earned her B.S. in Biomedical Engineering, Ph.D. (with Distinction) in Cellular & Molecular Physiology, and performed her postdoctoral training in Medicine/Endocrinology, all in the laboratory of Dr. Gerald Shulman. Rachel's CV includes first-author papers in Nature, Cell (2), Science, JCI, PNAS, Nature Medicine (2), PNAS, Nature Communications (3), JBC, Cell Metabolism (2), and AJP-Endocrinology. 

    The Perry laboratory focuses on applying stable isotope tracer methods to understand obesity- and insulin-associated alterations in metabolic flux pathways. Dr. Perry and her colleagues have recently identified hyperinsulinemia-induced increases in tumor glucose uptake and oxidation as a critical driver of colon cancer in two mouse models of the disease, and mitochondrial uncoupling as a potential therapeutic strategy against the disease (Wang et al. Cell Reports 2018, Nasiri et al. Cancer & Metabolism 2019), and went on to show that responsiveness to insulin is a metabolic signature of obesity-associated tumor types in vitro (Rabin-Court et al. PLoS One 2019). 

    Current projects in the Perry lab include:

    1. What is the molecular mechanism by which obesity and hyperinsulinemia promote tumor growth? How does insulin alter rates of glycolytic, oxidative, and anaplerotic metabolism? Can we invent better tracer methods than currently exist, allowing us to reliably measure rates of these pathways in vivo?

    2. What is the impact of exercise, a classic insulin-sensitizing intervention, on obesity-associated tumor growth - and what is the mechanism?

    3. Are alterations in tumor immunometabolism permissive for tumor progression? How does cancer therapy alter substrate preference in immune cells? Can we exploit systemic metabolic changes to enhance anti-cancer immunity?

    4. How do tumor metabolism and immunometabolism differ - in rate and regulation - in metastases as compared to primary tumor?

    5. What drives the changes in glucose metabolism commonly observed in inflammation that occurs following various stimuli? (Close collaboration with Dr. Andrew Wang's lab.) 

  • Deputy Chair and Anthony N. Brady Associate Professor of Comparative Medicine

    Yajaira studied Biochemistry and Molecular Biology at the University Autonoma of Madrid (1995). She did her PhD with Miguel Angel Lasuncion at the Hospital Ramón y Cajal and the University Autonoma de Madrid (Spain) (1996-2001). Yajaira also did two post-docs. The first one with Alberto Muñoz at the Instituto de Investigaciones Biomédicas "Alberto Sols" and the Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid (Spain) (2002-2005) and the second one with Jordan Pober and Bill Sessa at Yale University School of Medicine (2005-2009). Yajaira initiated her independent research career in the Division of Cardiology at New York University School of Medicine in 2009. She joined the Yale faculty in 2013 as an Assistant Professor of Comparative Medicine and Pathology. Yajaira is currently Associate Professor and also serves as Deputy Chair for the Department of Comparative Medicine. 

  • Professor

    Dr. Xiaoyong Yang is a Professor of Comparative Medicine and of Cellular & Molecular Physiology at Yale University School of Medicine. He received B.S. from Nankai University, M.S. from Peking University, and Ph.D. from University of Alabama at Birmingham with Dr. Jeffrey Kudlow. He completed his postdoctoral training with Dr. Ronald Evans at The Salk Institute. Dr. Yang has published in Nature, Cell, Cell Metabolism, Molecular Cell, Genes & Development, PNAS, etc., and been frequently invited to speak at national and international conferences and academic institutions. Dr. Yang serves on scientific review panels for the NIDDK, NIGMS, NASA, American Diabetes Association, American Cancer Society, The Medical Research Council, The Wellcome Trust, National Natural Science Foundation of China, etc. Research in his laboratory is supported by The National Institutes of Health, The State of Connecticut, American Diabetes Association, American Heart Association, American Cancer Society and Ellison Medical Foundation.