Current, Future, & Past Issues
Upcoming Issues
- June 2025: Epigenetics
- September 2025: History of Medicine
- December 2025: Neglected Tropical Diseases and Parasites (
submission deadline: July 1, 2025) - March 2026: Neurodevelopment and Neurodegeneration (submission deadline: Dec 8, 2025)
At the core of epigenetics are mechanisms that selectively control genome accessibility and availability. Molecular marks and tags shift the genome architecture, dynamically yet precisely opening up or coiling DNA to modulate gene expression. This ethereal and surrealist-inspired cover art depicts a DNA strand in motion – sequentially coiling around histones and eventually transitioning into a chromosome. The context or environment driving these changes is left obscure, represented by a psychedelic background that blends from underwater to interstellar. The June 2025 issue covers epigenetic mechanisms with fundamental and translational perspectives, examining their impact at the level of cells to organisms and communities.
Caption by Deputy Editors Reem Abu-Shamma and Andriana Marijic Buljubasic.
Cover art by Peter Harris.
Deputy Editors for June 2025: Epigenetics
Reem Abu-Shamma, Department of Genetics, Yale School of Medicine and Andriana Marijic Buljubasic, Yale School of Public Health
Editor Picks
Overweight/Obesity and Ancestral Environmental Smoking Exposures: A Summary of Results from the ALSPAC Cohort
Sarah Watkins, Matthew Suderman, Yasmin Iles-Caven, Kate Northstone, Marcus Pembrey, Jean Golding
Integrated Gene and Isoform-Level Transcriptomic Analysis of Adverse Childhood Experiences in the Human Prefrontal Cortex
Diana L. Núñez-Ríos, Sheila T. Nagamatsu, José Jaime Martínez-Magaña, Traumatic Stress Brain Research Group, Janitza L. Montalvo-Ortiz
Tracking Epigenetic Biomarkers of Health and Aging During the Initial Year of Gender-Affirming Hormone Therapy
Khyobeni Mozhui, Beck A. Henriksen, Lauren A. Bell, Ingrid Bretherton, Ada S. Cheung, Boris Novakovic
Cell-Derived Epigenomic Markers of Chronic Stress Distinguish Breast Cancer Phenotypes
Amrita Acharya, Anthony S. Zannas
Pharmacoepigenetic Biomarkers in Inflammatory Bowel Diseases: A Narrative Review
Jatniel E. Servian, Brianna Brady, Pritam Biswas, T. K. Sukumar, Stephanie E. King
2025 Issues
2024 Issues
Stylized journal cover art featuring a human bust with exaggerated halftone dots, resembling an electron micrograph. A stream of antibodies winds through clusters of yellow-orange viruses, with the changing color reflecting the viruses’ influence. As the antibodies reach the human bust, they become red, which symbolizes the chaotic and dangerous autoimmune response. Original cover design by Peter Harris. Caption by Peter Harris, RuthMabel Boytz, and Evan Navori.
Integrative Medicine – September 2024
Just like a spectrum of light can be combined into white light, integrative medicine draws from a variety of traditions and practices to tackle mental and physical wellbeing in a way that addresses patients' needs from diagnosis through recovery. Depicted in this cover are just some of these practices; therapy and group support, herbal supplements, cellular biology research, Chinese medicinal traditions, genetic scenery, and wellness & mindfulness practices. Caption and original cover design by Peter Harris.
Integrative Medicine – September 2024
Individuals with a chronic disease face a challenging landscape on their journey to meet with healthcare providers and often face under-acknowledged internal and external obstacles on the route to seeking help. While these experiences may be clear to individual patients, the shared commonalities across different chronic diseases are less connected in the literature as the very nature of what constitutes a chronic disease continues to be debated. This issue features discussions and research findings relevant across the umbrella of chronic disease, uniting topics from patient perspectives to emerging therapeutics. Caption by Noah Yann Lee and Bassel Shanab. Original cover design by Peter Harris.
Pregnancy is a time of radical and rapid change with acute implications for the health of expecting parents and child, from conception well into the postpartum period. The physiological changes brought about by pregnancy, education about healthcare options, and social support both before and after birth are just some of the factors that can have a drastic impact on the success of a pregnancy and the child's development. This issue explores how we can better understand pregnancy's impact on emotional and physical wellbeing, and how outcomes might be improved for the experience that began all our lives. Caption by Peter Harris. Original cover design by Peter Harris.
2023 Issues
From the ATCG sequences of our genetic code to the detailed chronicles of our healthcare encounters, the pulse of life is ever being captured in "Big Data." In this realm of boundless 1s and 0s, the world of medicine finds itself at the heart of the data revolution. We invite you into this issue as we explore the ever-evolving techniques researchers are deploying to grapple with big data and discern critical patterns that have the potential to revolutionize clinical decision-making and patient care. Caption by Conrad Safranek. Original cover design by Peter Harris.
Our world is evolving drastically from the effects of man-made climate change. As our environment changes, we continue to face new healthcare challenges; from physical ailments, to mental health issues, to climate and medical justice obligations. This cover draws inspiration from the extraordinary images that recently came out of the East coast of the United States, as wildfires in Canada brought an unprecedented level of atmospheric pollution to major population centers. Events like these serve as a stark reminder that our planet is changing, and that we must urgently work to address both the causes of climate change and the health issues arising from it. Caption by Peter Harris. Original cover design by Peter Harris.
2022 Issues
Antimicrobial Resistance - December 2022
The field of Bioethics rests on four pillars: patient autonomy, beneficence, nonmaleficence, and social justice. In this cover, a figure wielding a staff resembling the rod of Asclepius stands at a compass, which points towards architecture representing these four values. Caption and original cover design by Peter Harris.
Bioethics - September 2022
Vaccines – June 2022
The Science of Stress - March 2022
2021 Issues
Rare Disease - December 2021
Health Equity - September 2021
Zoonotic Disease - June 2021
Preventive Medicine - March 2021
2020 Issues
Allergic Diseases and Type II Immunity - December 2020
Sex and Reproduction - September 2020
Medical Education - August 2020
Plant-based Medicine and Pharmacology - June 2020
Skin - March 2020
2019 Issues
Death - December 2019
Organelles - September 2019
Clocks and Cycles - June 2019
Attention Science - March 2019
2018 Issues
Ecology and Evolution - December 2018
Medical Technology - September 2018
Nutrition and Food Science - June 2018
Sensory Biology and Pain - March 2018
2017 Issues
Gene Editing - December 2017
Comparative Medicine - September 2017
Infectious Diseases - June 2017
Drug Development - March 2017
2016 Issues
Epigenetics - December 2016
The Microbiome - September 2016
Sex and Gender Health - June 2016
The Aging Brain - March 2016
2015 Issues
Personalized Medicine - December 2015
Addiction - September 2015
A Multifaceted Battle Against Cancer - June 2015
Autism Spectrum Disorders - March 2015