2020
Cardiovascular Imaging of Biology and Emotion
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. Cardiovascular Imaging of Biology and Emotion. Circulation Cardiovascular Imaging 2020, 13: e011054. PMID: 32762255, PMCID: PMC9261020, DOI: 10.1161/circimaging.120.011054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMental stressEpicardial coronary artery diseaseCoronary artery diseaseExercise-induced changesMicrovascular dysfunctionArtery diseaseObstructive diseaseClinical manifestationsVascular responsesCentral activationCardiovascular healthPathophysiologic changesCardiovascular responsesMyocardial ischemiaPeripheral vasculatureTreatment targetsVascular pathophysiologyPsychosocial determinantsCardiovascular imagingPsychosocial experiencesImplementation studyMS testingTriggers activationCardiovascular biologyDisease
2016
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCells, CulturedCoronary Artery DiseaseCoronary VesselsFemaleGenetic Predisposition to DiseaseHumansInflammation MediatorsInterleukin 1 Receptor Antagonist ProteinInterleukin-1betaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptidesPhenotypePlaque, AtheroscleroticPrognosisRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSignal TransductionTransfectionUp-RegulationVascular CalcificationConceptsCoronary calcium burdenIL-1β expressionCalcium burdenSerum IL-1β levelsElevated IL-1βIL-1β levelsCoronary artery diseaseInterleukin-1β expressionCalcified coronary arteryCardiovascular deathCardiovascular eventsArtery diseaseIndependent predictorsClinical outcomesVascular calcificationCoronary arteryIL-1βPlaque calciumAtherosclerotic calcificationExperimental atherogenesisInflammatory regulatorsMacrophage interleukinAtherosclerotic plaquesTherapeutic targetProgressive calcification
2002
Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia.
Shi CQ, Young LH, Daher E, DiBella EV, Liu YH, Heller EN, Zoghbi S, Wackers FJ, Soufer R, Sinusas AJ. Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia. Journal Of Nuclear Medicine 2002, 43: 421-31. PMID: 11884504.Peer-Reviewed Original Research
2001
Comparison of [18F]altanserin and [18F]deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain: pharmacological studies
Staley J, Van Dyck C, Tan P, Tikriti M, Ramsby Q, Klump H, Ng C, Garg P, Soufer R, Baldwin R, Innis R. Comparison of [18F]altanserin and [18F]deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain: pharmacological studies. Nuclear Medicine And Biology 2001, 28: 271-279. PMID: 11323237, DOI: 10.1016/s0969-8051(00)00212-2.Peer-Reviewed Original ResearchConceptsReceptor antagonist SR 46349BSerotonin2A receptorsSR 46349BReceptor radiotracerPharmacological specificityTime-activity curvesConstant infusionBaboon brainCortical activityDistribution volumePharmacological studiesPET imagingRadiotracerBrainReceptorsBaboonsPET imagesRegional distributionFenfluramineInfusionBolus
2000
Persistent Changes in Myocardial Glucose Metabolism In Vivo During Reperfusion of a Limited-Duration Coronary Occlusion
McNulty P, Jagasia D, Cline G, Ng C, Whiting J, Garg P, Shulman G, Soufer R. Persistent Changes in Myocardial Glucose Metabolism In Vivo During Reperfusion of a Limited-Duration Coronary Occlusion. Circulation 2000, 101: 917-922. PMID: 10694532, DOI: 10.1161/01.cir.101.8.917.Peer-Reviewed Original ResearchConceptsCoronary occlusionGlucose metabolismPostischemic stunningAnterolateral left ventricleHeart glucose metabolismCoronary artery occlusionRegional glucose metabolismMyocardial glucose metabolismRegional myocardial ischemiaRegional mechanical functionRapid reperfusionReversible coronary occlusionArtery occlusionMyocardial ischemiaIntact ratsPreferential shuntingBlood flowReperfusionTracer uptakeLeft ventricleGlycogen depletionMetabolic signaturesOcclusionPersistent changesSustained changes
1997
Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters
Zea-Ponce Y, Baldwin R, Stratton M, Al-Tikriti M, Soufer R, Schaus J, Innis R. Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters. Nuclear Medicine And Biology 1997, 24: 251-254. PMID: 9228659, DOI: 10.1016/s0969-8051(97)00062-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarrier ProteinsChromatography, High Pressure LiquidCitalopramFemaleIsotope LabelingMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsOvariectomyPapioParoxetinePiperazinesRadiopharmaceuticalsRatsRats, Sprague-DawleySelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSpectrophotometry, UltravioletTetrahydronaphthalenesTomography, Emission-ComputedConceptsSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramReuptake inhibitor citalopramHigh brain uptakeSame brain regionsPositron emission tomographySerotonergic areasBrain uptakeMin postinjectionNontarget ratioUseful agentBrain regionsEmission tomographyN-methylMCi/mumolPET imagingNonspecific uptakeVivo studiesPartial inhibitionRadiochemical purityRadioactivity concentrationThalamusStriatumSerotoninCitalopram
1996
Autoregulation of myocardial glycogen concentration during intermittent hypoxia
McNulty P, Ng C, Liu W, Jagasia D, Letsou G, Baldwin J, Soufer R. Autoregulation of myocardial glycogen concentration during intermittent hypoxia. American Journal Of Physiology 1996, 271: r311-r319. PMID: 8770128, DOI: 10.1152/ajpregu.1996.271.2.r311.Peer-Reviewed Original Research
1995
Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance
Arrighi J, Soufer R. Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance. Journal Of Nuclear Cardiology 1995, 2: 525-543. PMID: 9420835, DOI: 10.1016/s1071-3581(05)80045-5.Peer-Reviewed Original ResearchConceptsDiastolic functionVentricular fillingHeart failureElevated pulmonary venous pressureNormal systolic ventricular functionSystolic ventricular functionNormal systolic functionCongestive heart failurePulmonary venous pressureCoronary artery diseaseCalcium channel blockersEarly ventricular fillingHealthy elderly subjectsMitral valve closureBeta blockersSystolic functionArtery diseaseCardiac catheterizationSuch patientsValvular diseaseVenous pressureVentricular functionOptimal therapyRadionuclide angiographyMyocardial complianceKinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia.
Ng C, Sinusas A, Zaret B, Soufer R. Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia. Circulation 1995, 92: 1261-8. PMID: 7648674, DOI: 10.1161/01.cir.92.5.1261.Peer-Reviewed Original ResearchSynthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil
Baldwin R, Horti A, Bremner J, Stratton M, Dannals R, Ravert H, Zea-Ponce Y, Ng C, Dey H, Soufer R, Charney D, Mazza S, Sparks R, Stubbs J, Innis R. Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil. Nuclear Medicine And Biology 1995, 22: 659-665. PMID: 7581177, DOI: 10.1016/0969-8051(94)00139-b.Peer-Reviewed Original ResearchConceptsHuman biodistribution dataUrinary bladder wallReceptor tracerHealthy human volunteersPositron emission tomographyBladder wallHigh doseBenzodiazepine receptorsTime-activity curvesUseful agentSPECT studiesEmission tomographyHuman volunteersBiodistribution dataAdult baboonsMCi/mumolPET imagingRadiation dosesN-methylEffective dose equivalentInjectionPurity 99MinCortexDose
1993
Metabolic imaging with positron emission tomography during myocardial reperfusion.
Soufer R. Metabolic imaging with positron emission tomography during myocardial reperfusion. American Journal Of Cardiac Imaging 1993, 7: 39-44. PMID: 10150107.Peer-Reviewed Original Research
1992
Left Ventricular Diastolic Function during Positive End-expiratory Pressure: Impact of Right Ventricular Ischemia and Ventricular Interaction
Schulman D, Biondi J, Zohgbi S, Cecchetti A, Zaret B, Soufer R. Left Ventricular Diastolic Function during Positive End-expiratory Pressure: Impact of Right Ventricular Ischemia and Ventricular Interaction. American Journal Of Respiratory And Critical Care Medicine 1992, 145: 515-521. PMID: 1546829, DOI: 10.1164/ajrccm/145.3.515.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureLeft ventricular end-diastolic pressure-volume relationEnd-expiratory pressureRCA occlusionEnd-diastolic volumeEnd-systolic volumeCardiac outputEjection fractionRight ventricularAddition of PEEPRight coronary artery occlusionEnd-diastolic pressure-volume relationRight ventricular ischemiaVentricular diastolic functionVentricular ejection fractionCoronary artery occlusionArtery occlusionAtrial pressureDiastolic functionPressure-volume relationVentricular ischemiaAnesthetized dogsVentricular interactionLV volumesRVEDV
1990
Coronary Flow Limits Right Ventricular Performance during Positive End-expiratory Pressure
Schulman D, Biondi J, Zohgbi S, Zaret B, Soufer R. Coronary Flow Limits Right Ventricular Performance during Positive End-expiratory Pressure. American Journal Of Respiratory And Critical Care Medicine 1990, 141: 1531-1537. PMID: 2190508, DOI: 10.1164/ajrccm/141.6.1531.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureRight ventricular ejection fractionH2O positive end-expiratory pressureEnd-diastolic volumeRight ventricular performanceMyocardial blood flowRCA occlusionEnd-expiratory pressureBlood flowVentricular performanceRight ventricular myocardial blood flowRight coronary blood flowRight coronary artery occlusionVentricular myocardial blood flowVentricular ejection fractionCoronary blood flowCoronary artery occlusionEnd-ejection volumeArtery occlusionEjection fractionPressure-volume relationRCA flowExperimental modelOcclusion