Publications

1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity

DOYLE E, FOGELMAN N, JOSEPH K, HU P, JASTREBOFF A, SINHA R. 1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1771-p.

Peer-Reviewed Original Research

1761-P: Sex Differences in Emotion Regulation, Leptin, and Eating Behavior in Response to Stress and Food Cues

HORVATH-DIANO C, DAUGINIKAS E, HEILNER E, SAKMAR E, SINHA R, HARVANEK Z. 1761-P: Sex Differences in Emotion Regulation, Leptin, and Eating Behavior in Response to Stress and Food Cues. Diabetes 2025, 74 DOI: 10.2337/db25-1761-p.

Peer-Reviewed Original Research

649-P: Sex Differences in Predictors of Food Craving, Eating Behavior, and Weight Changes Assessed Longitudinally over a 24-Month Period

DAUGINIKAS E, HORVATH-DIANO C, HEILNER E, SAKMAR E, SINHA R, HARVANEK Z. 649-P: Sex Differences in Predictors of Food Craving, Eating Behavior, and Weight Changes Assessed Longitudinally over a 24-Month Period. Diabetes 2025, 74 DOI: 10.2337/db25-649-p.

Peer-Reviewed Original Research

Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma

Heilner E, Sinha R, Eringros N, Constable R, Seo D. Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma. Journal Of Neural Transmission 2025, 1-16. PMID: 40500419, DOI: 10.1007/s00702-025-02961-9.

Peer-Reviewed Original Research

Examining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder

Radoman M, Heilner E, McGowan C, Neree-Thompson B, Sakmar E, Sinha R. Examining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder. Alcohol 2025, 127: 55-61. PMID: 40513686, PMCID: PMC12276962, DOI: 10.1016/j.alcohol.2025.06.001.

Peer-Reviewed Original Research

Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction

Huang Y, Butelman E, Ceceli A, Kronberg G, King S, McClain N, Wong Y, Boros M, Drury K, Sinha R, Alia-Klein N, Goldstein R. Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction. Biological Psychiatry 2025 PMID: 40441339, PMCID: PMC12359307, DOI: 10.1016/j.biopsych.2025.05.016.

Peer-Reviewed Original Research

623. Alcohol Use Disorder is Associated With Disruptions in Neurohormonal Signaling Pathways

Harvanek Z, Hart R, Guarnaccia J, Sinha R. 623. Alcohol Use Disorder is Associated With Disruptions in Neurohormonal Signaling Pathways. Biological Psychiatry 2025, 97: s355. DOI: 10.1016/j.biopsych.2025.02.862.

Peer-Reviewed Original Research

Race-Related Differences in Protective Effects of Emotion Regulation Against GrimAge Acceleration Are Driven by Assaultive Trauma

Chowdhary A, Holloway T, Xu K, Sinha R, Harvanek Z. Race-Related Differences in Protective Effects of Emotion Regulation Against GrimAge Acceleration Are Driven by Assaultive Trauma. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 40232770, PMCID: PMC12354006, DOI: 10.1037/tra0001888.

Peer-Reviewed Original Research

512 Predicting outcomes of lifestyle and stress reduction interventions for obesity with DNA methylation and psychological measures

Harvanek Z, Li C, Xu K, Jastreboff A, Sinha R. 512 Predicting outcomes of lifestyle and stress reduction interventions for obesity with DNA methylation and psychological measures. Journal Of Clinical And Translational Science 2025, 9: 150-150. PMCID: PMC12050514, DOI: 10.1017/cts.2024.1093.

Peer-Reviewed Original Research

W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study

Wemm S, Fogelman N, Sullivan L, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study. Drug And Alcohol Dependence 2025, 267: 112081. DOI: 10.1016/j.drugalcdep.2024.112081.

Peer-Reviewed Original Research

Concepts

M125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder

Fogelman N, McGowan C, Wemm S, Tate M, Hermes G, Sinha R, Wemm S. M125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder. Drug And Alcohol Dependence 2025, 267: 111719. DOI: 10.1016/j.drugalcdep.2024.111719.

Peer-Reviewed Original Research

Concepts

Pregnenolone Effects on Cocaine Use in Individuals with Cocaine Use Disorder

Milivojevic V, Sakmar E, Fogelman N, Hermes G, Sinha R. Pregnenolone Effects on Cocaine Use in Individuals with Cocaine Use Disorder. Drug And Alcohol Dependence 2025, 267: 112227. DOI: 10.1016/j.drugalcdep.2024.112227.

Peer-Reviewed Original Research

Role of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery

Seo D, Choi J, Sinha R, De Aquiar R. Role of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery. Drug And Alcohol Dependence 2025, 267: 112197. DOI: 10.1016/j.drugalcdep.2024.112197.

Peer-Reviewed Original Research

Concepts

W33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD

Conway R, Pearlman M, Sinha R, Wemm S, Conway R. W33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD. Drug And Alcohol Dependence 2025, 267: 111975. DOI: 10.1016/j.drugalcdep.2024.111975.

Peer-Reviewed Original Research

Concepts

Positive affect amplifies integration within episodic memories in the laboratory and the real world.

Pratt J, Wemm S, Harris B, Huang Y, Sinha R, Goldfarb E. Positive affect amplifies integration within episodic memories in the laboratory and the real world. Learning & Memory 2025, 32: a053971. PMID: 39870487, PMCID: PMC11801478, DOI: 10.1101/lm.053971.124.

Peer-Reviewed Original Research

Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder

Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.

Peer-Reviewed Original Research

Stress and Addictive Disorders: Drug- and Stressor-related Effects on Stress Biological and Psychological Response

Wemm S, Pearlman M, Sinha R. Stress and Addictive Disorders: Drug- and Stressor-related Effects on Stress Biological and Psychological Response. 2025, 145-162. DOI: 10.4135/9781529673913.n10.

Peer-Reviewed Original Research

Concepts

Publications

2025

1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity

1761-P: Sex Differences in Emotion Regulation, Leptin, and Eating Behavior in Response to Stress and Food Cues

649-P: Sex Differences in Predictors of Food Craving, Eating Behavior, and Weight Changes Assessed Longitudinally over a 24-Month Period

Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma

Examining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder

Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction

623. Alcohol Use Disorder is Associated With Disruptions in Neurohormonal Signaling Pathways

Race-Related Differences in Protective Effects of Emotion Regulation Against GrimAge Acceleration Are Driven by Assaultive Trauma

512 Predicting outcomes of lifestyle and stress reduction interventions for obesity with DNA methylation and psychological measures

W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study

M125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder

Pregnenolone Effects on Cocaine Use in Individuals with Cocaine Use Disorder

Role of Altered Neural Circuits of Stress and Reward Regulation in Alcohol Use Disorder and Treatment-Related Recovery

W33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD

Positive affect amplifies integration within episodic memories in the laboratory and the real world.

Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder

Stress and Addictive Disorders: Drug- and Stressor-related Effects on Stress Biological and Psychological Response

2024

Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder

Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings

Mindfulness-based therapy for insomnia in Black women: a pilot randomized controlled trial

Network state dynamics underpin basal craving in a transdiagnostic population

Stress and substance use disorders: risk, relapse, and treatment outcomes

Drawbacks to Strengthening Neural Salience Encoding: A Link Between Cortisol and Risky Drinking

Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake

S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder