2024
Promoting Collaborative Scholarship During the COVID-19 Pandemic Through an Innovative COVID-19 Data Explorer and Repository at Yale School of Medicine: Development and Usability Study
Victoria-Castro A, Arora T, Simonov M, Biswas A, Alausa J, Subair L, Gerber B, Nguyen A, Hsiao A, Hintz R, Yamamoto Y, Soufer R, Desir G, Wilson F, Villanueva M. Promoting Collaborative Scholarship During the COVID-19 Pandemic Through an Innovative COVID-19 Data Explorer and Repository at Yale School of Medicine: Development and Usability Study. JMIR Formative Research 2024, 8: e52120. PMID: 39226547, PMCID: PMC11408881, DOI: 10.2196/52120.Peer-Reviewed Original Research
2023
The Brain–Heart Axis: Neuroinflammatory Interactions in Cardiovascular Disease
Hu J, Abdullah A, Nanna M, Soufer R. The Brain–Heart Axis: Neuroinflammatory Interactions in Cardiovascular Disease. Current Cardiology Reports 2023, 25: 1745-1758. PMID: 37994952, PMCID: PMC10908342, DOI: 10.1007/s11886-023-01990-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHeart-brain axisCardiovascular diseaseRenin angiotensin aldosteroneDevelopment of strokeBrain-heart axisAbnormal atrial substrateParasympathetic nervous systemNeuroimmune modulationNeuroinflammatory interactionsNeurogenic inflammationCardioembolic strokeNeurologic insultProinflammatory factorsCardiac dysfunctionAtrial fibrillationAfferent pathwaysAtrial substrateHypothalamus-pituitary axesSpinal injuryCommon disorderCommon conditionProinflammatory signalsNervous systemRecent FindingsAtPrototypical disorderDelirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes
Park D, Jamil Y, Hu J, Lowenstern A, Frampton J, Abdullah A, Damluji A, Ahmad Y, Soufer R, Nanna M. Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes. Cardiovascular Revascularization Medicine 2023, 57: 60-67. PMID: 37414611, PMCID: PMC10730763, DOI: 10.1016/j.carrev.2023.06.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityHigher oddsOlder adultsHospital deliriumCoronary interventionAdverse health-related outcomesInpatient percutaneous coronary interventionNon-home dischargePeri-procedural settingAcute kidney injuryImpact of deliriumPost-procedural complicationsNational Inpatient SampleHealth-related outcomesDelirium preventionHospital complicationsMore comorbiditiesGastrointestinal hemorrhageKidney injuryAdverse eventsSecondary outcomesBlood transfusionPrimary outcomeIntracranial hemorrhage
2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac responseEffects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal
Shah SM, Meadows JL, Burg MM, Pfau S, Soufer R. Effects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal. Current Cardiology Reports 2020, 22: 156. PMID: 33037500, DOI: 10.1007/s11886-020-01406-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPsychological stressCardiovascular diseaseMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaMental stressVascular smooth muscleMental stress effectsVascular systemCardiovascular imaging modalitiesEntire vascular systemCardiovascular manifestationsVascular effectsMicrovascular resistanceMicrovascular responsesVascular changesVascular mechanismsVascular responsesCardiovascular responsesMyocardial ischemiaLong-term consequencesSmooth muscleMicrovascular compartmentTherapeutic interventionsReviewThis reviewStandardized psychological assessmentsRelationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean ageCardiovascular Imaging of Biology and Emotion
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. Cardiovascular Imaging of Biology and Emotion. Circulation Cardiovascular Imaging 2020, 13: e011054. PMID: 32762255, PMCID: PMC9261020, DOI: 10.1161/circimaging.120.011054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMental stressEpicardial coronary artery diseaseCoronary artery diseaseExercise-induced changesMicrovascular dysfunctionArtery diseaseObstructive diseaseClinical manifestationsVascular responsesCentral activationCardiovascular healthPathophysiologic changesCardiovascular responsesMyocardial ischemiaPeripheral vasculatureTreatment targetsVascular pathophysiologyPsychosocial determinantsCardiovascular imagingPsychosocial experiencesImplementation studyMS testingTriggers activationCardiovascular biologyDisease
2019
Effect of β-blockers on triggering of symptomatic atrial fibrillation by anger or stress
Lampert R, Burg MM, Jamner LD, Dziura J, Brandt C, Li F, Donovan T, Soufer R. Effect of β-blockers on triggering of symptomatic atrial fibrillation by anger or stress. Heart Rhythm 2019, 16: 1167-1173. PMID: 31171436, PMCID: PMC6759206, DOI: 10.1016/j.hrthm.2019.03.004.Peer-Reviewed Original ResearchConceptsAtrial fibrillationΒ-blockersAF episodesHistory of AFControl periodSymptomatic AF episodesSymptomatic atrial fibrillationΒ-blocker useExclusion of patientsPersistent atrial fibrillationHolter monitoringAF symptomsPatientsPatient exposureCase periodFibrillationMood statesEpisodesEvent monitorDeleterious physiological responsesExposurePhysiological responsesDiary dataSotalol
2017
The interface of emotion and biology in myocardial ischemia: Can we progress using the traditional paradigm?
Soufer R, Burg MM. The interface of emotion and biology in myocardial ischemia: Can we progress using the traditional paradigm? Journal Of Nuclear Cardiology 2017, 24: 783-787. PMID: 28155190, DOI: 10.1007/s12350-016-0762-2.Peer-Reviewed Original ResearchConceptsBiology
2016
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCells, CulturedCoronary Artery DiseaseCoronary VesselsFemaleGenetic Predisposition to DiseaseHumansInflammation MediatorsInterleukin 1 Receptor Antagonist ProteinInterleukin-1betaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptidesPhenotypePlaque, AtheroscleroticPrognosisRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSignal TransductionTransfectionUp-RegulationVascular CalcificationConceptsCoronary calcium burdenIL-1β expressionCalcium burdenSerum IL-1β levelsElevated IL-1βIL-1β levelsCoronary artery diseaseInterleukin-1β expressionCalcified coronary arteryCardiovascular deathCardiovascular eventsArtery diseaseIndependent predictorsClinical outcomesVascular calcificationCoronary arteryIL-1βPlaque calciumAtherosclerotic calcificationExperimental atherogenesisInflammatory regulatorsMacrophage interleukinAtherosclerotic plaquesTherapeutic targetProgressive calcificationPost-traumatic Stress Disorder and Cardiovascular Disease
Burg MM, Soufer R. Post-traumatic Stress Disorder and Cardiovascular Disease. Current Cardiology Reports 2016, 18: 94. PMID: 27566327, DOI: 10.1007/s11886-016-0770-5.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderCardiovascular diseaseStress disorderIncident hypertension riskIncident cardiovascular diseaseAcute cardiac eventsEmergency department environmentCardiac eventsCardiovascular mortalityEarly recurrenceMilitary veteran sampleHypertension riskClinical pathwayPatient experiencePTSD treatmentPTSD onsetTrauma exposureVeteran sampleAutomobile accidentsDepartment environmentMortalityDiseaseRiskTraumaDisordersBody Mass Index and Risk for Mental Stress-Induced Ischemia in Coronary Artery Disease
Soufer R, Fernandez AB, Meadows J, Collins D, Burg MM. Body Mass Index and Risk for Mental Stress-Induced Ischemia in Coronary Artery Disease. Molecular Medicine 2016, 22: 286-291. PMID: 27261777, PMCID: PMC5023512, DOI: 10.2119/molmed.2016.00128.Peer-Reviewed Original ResearchBody mass indexHigher body mass indexMental stressMass indexChronic inflammationAutonomic dysregulationMyocardial ischemiaTraditional coronary artery disease risk factorsConfidence intervalsCoronary artery disease risk factorsMean body mass indexGreater body mass indexLaboratory mental stressHistory of hypertensionIndependent risk markerDisease risk factorsProspective interventional studyCoronary artery diseaseMultivariate logistic regressionMyocardial blood flowSingle photon emissionStress–Induced IschemiaCAD mortalityElevated markersStable CAD
2014
Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion
Burg MM, Meadows J, Shimbo D, Davidson KW, Schwartz JE, Soufer R. Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion. Journal Of The American Heart Association 2014, 3: e000898. PMID: 25359402, PMCID: PMC4338683, DOI: 10.1161/jaha.114.000898.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionChronic DiseaseConnecticutCoronary CirculationCoronary DiseaseDepressionFemaleHemodynamicsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial Perfusion ImagingOdds RatioPredictive Value of TestsPsychiatric Status Rating ScalesRecurrenceRisk FactorsSeverity of Illness IndexStress, PsychologicalTomography, Emission-Computed, Single-PhotonConceptsAcute psychological stressMyocardial perfusionPsychological stressDepressed rangeNormal rangeAcute coronary syndrome (ACS) recurrenceSelective serotonin reuptake inhibitor medicationsStable coronary heart diseaseCoronary heart disease patientsSerotonin reuptake inhibitor medicationsImpaired myocardial perfusionTomography myocardial perfusionCoronary heart diseaseMortality risk factorsOptimal medical careHigh normal rangeReuptake inhibitor medicationsHeart disease patientsBeck Depression InventorySingle photon emissionACS recurrenceCHD prognosisInhibitor medicationVascular mechanismsMeasures of depressionTriggering of Symptomatic Atrial Fibrillation by Negative Emotion
Lampert R, Jamner L, Burg M, Dziura J, Brandt C, Liu H, Li F, Donovan T, Soufer R. Triggering of Symptomatic Atrial Fibrillation by Negative Emotion. Journal Of The American College Of Cardiology 2014, 64: 1533-1534. PMID: 25277622, DOI: 10.1016/j.jacc.2014.07.959.Peer-Reviewed Original ResearchPsychological Stress and Induced Ischemic Syndromes
Burg MM, Soufer R. Psychological Stress and Induced Ischemic Syndromes. Current Cardiovascular Risk Reports 2014, 8: 377. PMID: 24860639, PMCID: PMC4030631, DOI: 10.1007/s12170-014-0377-6.Peer-Reviewed Original Research
2013
Therapy for Mental Stress–Induced Myocardial Ischemia
Burg MM, Soufer R. Therapy for Mental Stress–Induced Myocardial Ischemia. JAMA 2013, 310: 1400-1401. PMID: 24084926, DOI: 10.1001/jama.2013.277951.Peer-Reviewed Original ResearchThe Role of Cardiovascular Nuclear Imaging in Clinical Consultation
Meadows J, Soufer R. The Role of Cardiovascular Nuclear Imaging in Clinical Consultation. 2013, 159-180. DOI: 10.1007/978-1-4471-4441-0_13.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseNuclear cardiology techniquesCardiovascular prognosisRevascularization strategyRisk stratificationCardiology testsMyocardial perfusionPerfusion imagingClinical consultationPhysiologic principlesConsultant evaluationCardiovascular Nuclear ImagingNuclear imagingDiseaseImagingPatientsPrognosisPerfusionDiagnosis
2011
Cardiac repolarization instability during psychological stress in patients with ventricular arrhythmias
Abisse SS, Lampert R, Burg M, Soufer R, Shusterman V. Cardiac repolarization instability during psychological stress in patients with ventricular arrhythmias. Journal Of Electrocardiology 2011, 44: 678-683. PMID: 21920534, PMCID: PMC3200452, DOI: 10.1016/j.jelectrocard.2011.07.019.Peer-Reviewed Original ResearchConceptsSubsequent ventricular tachyarrhythmiasVentricular tachyarrhythmiasGroup 2Group 1Life-threatening ventricular tachyarrhythmiasPsychological stressSubsequent arrhythmic eventsAutonomic nervous system activityNervous system activityCardiac repolarization instabilityICD implantationVentricular arrhythmiasArrhythmic eventsQT intervalRepolarization responseCardiac repolarizationHeart ratePatientsT-wave areaPsychological stressorsMental stressRepolarization instabilityCardiac physiologySystem activitySignificant differencesAutonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease
Burg MM, Soufer A, Lampert R, Collins D, Soufer R. Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease. Molecular Medicine 2011, 17: 495-501. PMID: 21267513, PMCID: PMC3105151, DOI: 10.2119/molmed.2010.00083.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Parasympathetic activityArtery diseaseAutonomic contributionsChronic stable coronary artery diseaseStable coronary artery diseaseCholinergic antiinflammatory pathwayLaboratory stressCoronary plaque ruptureEndothelin-1 increaseSignificant odds ratioEndothelial cell functionCardiac eventsEndothelial dysfunctionIndwelling catheterAutonomic factorsSympathetic activityAntiinflammatory pathwayAutonomic influencesAutonomic toneOdds ratioPlaque ruptureParasympathetic withdrawalHemodynamic monitor
2010
Depression Predicts Elevated Endothelin-1 in Patients With Coronary Artery Disease
Burg MM, Martens EJ, Collins D, Soufer R. Depression Predicts Elevated Endothelin-1 in Patients With Coronary Artery Disease. Psychosomatic Medicine 2010, 73: 2-6. PMID: 20947777, PMCID: PMC3016462, DOI: 10.1097/psy.0b013e3181fdfb25.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Beck Depression InventoryBDI scoresLogistic regression modelsArtery diseaseLog-transformed continuous variableRisk thresholdElevated endothelin-1ET-1 elevationET-1 levelsEvent-free survivalMorning blood samplesWorse depression symptomsDepression symptom severityEarly morbidityRegression modelsPoor survivalPlaque ruptureAdjusted modelBlood samplesDepressive symptomsDepression severityDepression symptomsDepression Inventory