2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsActivities of Daily LivingCoronary Artery DiseaseExercise TestHumansMyocardial IschemiaMyocardial Perfusion ImagingConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac responseEffects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal
Shah SM, Meadows JL, Burg MM, Pfau S, Soufer R. Effects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal. Current Cardiology Reports 2020, 22: 156. PMID: 33037500, DOI: 10.1007/s11886-020-01406-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCardiovascular DiseasesCardiovascular SystemCoronary Artery DiseaseHumansMyocardial IschemiaStress, PsychologicalConceptsPsychological stressCardiovascular diseaseMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaMental stressVascular smooth muscleMental stress effectsVascular systemCardiovascular imaging modalitiesEntire vascular systemCardiovascular manifestationsVascular effectsMicrovascular resistanceMicrovascular responsesVascular changesVascular mechanismsVascular responsesCardiovascular responsesMyocardial ischemiaLong-term consequencesSmooth muscleMicrovascular compartmentTherapeutic interventionsReviewThis reviewStandardized psychological assessments
2017
The interface of emotion and biology in myocardial ischemia: Can we progress using the traditional paradigm?
Soufer R, Burg MM. The interface of emotion and biology in myocardial ischemia: Can we progress using the traditional paradigm? Journal Of Nuclear Cardiology 2017, 24: 783-787. PMID: 28155190, DOI: 10.1007/s12350-016-0762-2.Peer-Reviewed Original ResearchConceptsBiology
2013
Therapy for Mental Stress–Induced Myocardial Ischemia
Burg MM, Soufer R. Therapy for Mental Stress–Induced Myocardial Ischemia. JAMA 2013, 310: 1400-1401. PMID: 24084926, DOI: 10.1001/jama.2013.277951.Peer-Reviewed Original Research
2009
Heart-brain interactions in mental stress-induced myocardial ischemia
Soufer R, Jain H, Yoon AJ. Heart-brain interactions in mental stress-induced myocardial ischemia. Current Cardiology Reports 2009, 11: 133-140. PMID: 19236829, PMCID: PMC3726062, DOI: 10.1007/s11886-009-0020-1.Peer-Reviewed Original ResearchConceptsMental stress ischemiaStress ischemiaMyocardial ischemiaMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaCoronary artery diseaseCentral nervous systemHeart-brain interactionsArtery diseasePoor prognosisAutonomic balancePathophysiologic underpinningsTreatment strategiesNervous systemIschemiaPsychosocial stressBiobehavioral aspectsBiobehavioral modelBiologic consequencesSensory inputBiologic processesBrainEmotional provocationPatientsPrognosis
2008
Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia
Burg MM, Graeber B, Vashist A, Collins D, Earley C, Liu J, Lampert R, Soufer R. Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia. Psychosomatic Medicine 2008, 71: 14-20. PMID: 18941131, PMCID: PMC2739989, DOI: 10.1097/psy.0b013e318187c035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngerAngiotensin-Converting Enzyme InhibitorsBlood PressureCoronary DiseaseEpinephrineFemaleHeart RateHumansImagery, PsychotherapyMaleManometryMiddle AgedMyocardial IschemiaNorepinephrinePlethysmographyPredictive Value of TestsPulsatile FlowRiskSensitivity and SpecificityStress, PsychologicalTomography, Emission-Computed, Single-PhotonVascular ResistanceConceptsPeripheral arterial tonometryCoronary artery diseasePAT ratioMyocardial ischemiaMajor adverse cardiac eventsStable coronary artery diseaseLower PAT ratioMental stress ischemiaAdverse cardiac eventsNew perfusion defectsCT myocardial perfusionSensitivity/specificityStress ischemiaArterial tonometryCardiac eventsArtery diseaseBlood pressureACE inhibitionPerfusion defectsHeart rateMyocardial perfusionPatientsEnzyme inhibitorsClinical settingIschemia
2007
Psychological Stress and Myocardial Ischemia: Understanding the Link and the Implications
Sheps DS, Soufer R, Freedland KE. Psychological Stress and Myocardial Ischemia: Understanding the Link and the Implications. Psychosomatic Medicine 2007, 69: 491-492. PMID: 17641143, DOI: 10.1097/psy.0b013e31814527c2.Peer-Reviewed Original ResearchMental stress–induced myocardial ischemia: Moving forward
Burg MM, Soufer R. Mental stress–induced myocardial ischemia: Moving forward. Journal Of Nuclear Cardiology 2007, 14: 269-271. PMID: 17556157, DOI: 10.1016/j.nuclcard.2007.04.009.Peer-Reviewed Original ResearchThe heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions.
Soufer R, Burg MM. The heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions. Cleveland Clinic Journal Of Medicine 2007, 74 Suppl 1: s59-62. PMID: 17455547, DOI: 10.3949/ccjm.74.suppl_1.s59.Peer-Reviewed Original ResearchConceptsMental stress-induced ischemiaStress-induced ischemiaMental stressMyocardial ischemiaAcute coronary syndromeRecurrent cardiac eventsSilent myocardial ischemiaRisk stratification algorithmLong-term outcomesTreatment of patientsHeart-brain interactionsDifferential pathophysiologyCoronary syndromeCardiac eventsRisk stratificationPoor prognosisTransient ischemiaVulnerable patientsStratification algorithmCortical hyperactivationEarly deathIschemiaDiagnostic testingClinical settingClinical goals
2006
C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia
Shah R, Burg MM, Vashist A, Collins D, Liu J, Jadbabaie F, Graeber B, Earley C, Lampert R, Soufer R. C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia. Molecular Medicine 2006, 12: 269-274. PMID: 17380191, PMCID: PMC1829194, DOI: 10.2119/2006-00077.shah.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseMyocardial perfusion imagingTransthoracic echocardiographyCRP levelsMental stressRisk markersMyocardial ischemiaLevels of CRPNew regional wall motion abnormalitiesAssociation of CRPRelationship of CRPSimultaneous single-photon emissionStable coronary artery diseaseUnivariate logistic regression analysisRegional wall motion abnormalitiesTetrofosmin myocardial perfusion imagingLaboratory mental stressRisk of MSISerum CRP levelsHistory of diabetesSubsequent clinical eventsNew perfusion defectsWall motion abnormalitiesLogistic regression analysis
2005
Mental stress ischemia: Present status and future goals
Burg MM, Vashist A, Soufer R. Mental stress ischemia: Present status and future goals. Journal Of Nuclear Cardiology 2005, 12: 523-529. PMID: 16171711, DOI: 10.1016/j.nuclcard.2005.06.085.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchHumansMyocardial IschemiaPractice Patterns, Physicians'PrognosisStress, PsychologicalConceptsEvent-free survival rateLarge-scale clinical trialsAssessment of prognosisForms of ischemiaComplex clinical manifestationsSubstantial clinical impactClinical manifestationsPrognostic significanceClinical trialsClinical impactSurvival rateDiagnostic standardizationTreatment effectsIschemiaNuclear cardiologyPrognosisPathophysiologySufficient evidenceAdditional modalitiesTrialsFurther testingTreatmentPrevalenceCardiology
2004
Neurocardiac Interaction During Stress-Induced Myocardial Ischemia
Soufer R. Neurocardiac Interaction During Stress-Induced Myocardial Ischemia. Circulation 2004, 110: 1710-1713. PMID: 15451806, DOI: 10.1161/01.cir.0000144841.84987.50.Peer-Reviewed Original Research
2002
Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia.
Shi CQ, Young LH, Daher E, DiBella EV, Liu YH, Heller EN, Zoghbi S, Wackers FJ, Soufer R, Sinusas AJ. Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia. Journal Of Nuclear Medicine 2002, 43: 421-31. PMID: 11884504.Peer-Reviewed Original Research
1998
Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake.
Ng C, Soufer R, McNulty P. Effect of hyperinsulinemia on myocardial fluorine-18-FDG uptake. Journal Of Nuclear Medicine 1998, 39: 379-83. PMID: 9529278.Peer-Reviewed Original ResearchConceptsCoronary sinus blood samplesIschemic heart diseasePrevious myocardial infarctionCoronary sinus catheterizationEffect of insulinLeft anteriorMale patientsMyocardial infarctionHeart diseaseFDG injectionVascular bedBlood samplesAwake statePatientsGlucose uptakeMyocardial kineticsFDGCatheterizationInfarctionDiabetesBolusAnteriorInsulinDisease
1995
Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia.
Ng C, Sinusas A, Zaret B, Soufer R. Kinetic analysis of technetium-99m-labeled nitroimidazole (BMS-181321) as a tracer of myocardial hypoxia. Circulation 1995, 92: 1261-8. PMID: 7648674, DOI: 10.1161/01.cir.92.5.1261.Peer-Reviewed Original Research
1993
Metabolic imaging with positron emission tomography during myocardial reperfusion.
Soufer R. Metabolic imaging with positron emission tomography during myocardial reperfusion. American Journal Of Cardiac Imaging 1993, 7: 39-44. PMID: 10150107.Peer-Reviewed Original Research