1997
Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters
Zea-Ponce Y, Baldwin R, Stratton M, Al-Tikriti M, Soufer R, Schaus J, Innis R. Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters. Nuclear Medicine And Biology 1997, 24: 251-254. PMID: 9228659, DOI: 10.1016/s0969-8051(97)00062-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCarrier ProteinsChromatography, High Pressure LiquidCitalopramFemaleIsotope LabelingMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsOvariectomyPapioParoxetinePiperazinesRadiopharmaceuticalsRatsRats, Sprague-DawleySelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSpectrophotometry, UltravioletTetrahydronaphthalenesTomography, Emission-ComputedConceptsSelective serotonin reuptake inhibitor citalopramSerotonin reuptake inhibitor citalopramReuptake inhibitor citalopramHigh brain uptakeSame brain regionsPositron emission tomographySerotonergic areasBrain uptakeMin postinjectionNontarget ratioUseful agentBrain regionsEmission tomographyN-methylMCi/mumolPET imagingNonspecific uptakeVivo studiesPartial inhibitionRadiochemical purityRadioactivity concentrationThalamusStriatumSerotoninCitalopram
1995
Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil
Baldwin R, Horti A, Bremner J, Stratton M, Dannals R, Ravert H, Zea-Ponce Y, Ng C, Dey H, Soufer R, Charney D, Mazza S, Sparks R, Stubbs J, Innis R. Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil. Nuclear Medicine And Biology 1995, 22: 659-665. PMID: 7581177, DOI: 10.1016/0969-8051(94)00139-b.Peer-Reviewed Original ResearchConceptsHuman biodistribution dataUrinary bladder wallReceptor tracerHealthy human volunteersPositron emission tomographyBladder wallHigh doseBenzodiazepine receptorsTime-activity curvesUseful agentSPECT studiesEmission tomographyHuman volunteersBiodistribution dataAdult baboonsMCi/mumolPET imagingRadiation dosesN-methylEffective dose equivalentInjectionPurity 99MinCortexDose