2016
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCells, CulturedCoronary Artery DiseaseCoronary VesselsFemaleGenetic Predisposition to DiseaseHumansInflammation MediatorsInterleukin 1 Receptor Antagonist ProteinInterleukin-1betaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptidesPhenotypePlaque, AtheroscleroticPrognosisRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSignal TransductionTransfectionUp-RegulationVascular CalcificationConceptsCoronary calcium burdenIL-1β expressionCalcium burdenSerum IL-1β levelsElevated IL-1βIL-1β levelsCoronary artery diseaseInterleukin-1β expressionCalcified coronary arteryCardiovascular deathCardiovascular eventsArtery diseaseIndependent predictorsClinical outcomesVascular calcificationCoronary arteryIL-1βPlaque calciumAtherosclerotic calcificationExperimental atherogenesisInflammatory regulatorsMacrophage interleukinAtherosclerotic plaquesTherapeutic targetProgressive calcification
1995
Reverse redistribution on planar thallium scintigraphy: relationship to resting thallium uptake and long-term outcome
Dey H, Soufer R. Reverse redistribution on planar thallium scintigraphy: relationship to resting thallium uptake and long-term outcome. European Journal Of Nuclear Medicine And Molecular Imaging 1995, 22: 237-242. PMID: 7789397, DOI: 10.1007/bf01081519.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseChronic coronary artery diseasePatient outcomesLogistic multiple regression analysisRR segmentsPlanar thallium scintigraphyLong-term outcomesRecent thrombolysisThallium reinjectionArtery diseaseThallium scintigraphyIndependent predictorsScintigraphic findingsPrognostic significanceMyocardial infarctionRedistribution imagesThallium uptakeThallium-201Physiologic basisScarred myocardiumMultiple regression analysisRegression analysisOutcomesThrombolysisInfarction