A Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar Disorder
Goldman D, Sankar A, Colic L, Villa L, Kim J, Pittman B, Constable R, Scheinost D, Blumberg H. A Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar Disorder. Biological Psychiatry 2022, 91: s38-s39. DOI: 10.1016/j.biopsych.2022.02.114.Peer-Reviewed Original ResearchGraph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder
Sankar A, Scheinost D, Goldman DA, Drachman R, Colic L, Villa LM, Kim JA, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie CM, Oquendo MA, Constable RT, Blumberg HP. Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder. Translational Psychiatry 2022, 12: 7. PMID: 35013103, PMCID: PMC8748935, DOI: 10.1038/s41398-021-01767-z.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity distributionBipolar disorderSuicide attemptsHealthy volunteersFunctional connectivity disturbancesSuicide behaviorWhole-brain functional connectivityPrior suicide attemptsRight anterior insulaBrain functional connectivitySuicidal ideation severityBilateral ventromedial prefrontal cortexFunctional magnetic resonanceSignificant group differencesTemporopolar cortexConnectivity disturbancesBrain targetsFC differencesHigh riskCerebellar cortexVentromedial prefrontal cortexSuicidal ideationOrbitofrontal cortexFunctional connectivitySuicide risk