2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionImprovements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatmentNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapy
2018
Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities
Ivezaj V, Barnes RD, Cooper Z, Grilo CM. Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities. General Hospital Psychiatry 2018, 54: 25-30. PMID: 30056316, PMCID: PMC6245943, DOI: 10.1016/j.genhosppsych.2018.07.002.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryBinge-eating disorderGastrectomy surgeryBinge Eating DisorderClinical featuresPatient groupControl eatingOW/OBOverweight/obesityBody mass indexRelevant patient groupsMass indexDepressive symptomsSurgeryPast monthBED groupWeight concernsWeekly lossDisordersCareful assessmentObesityOnly groupQuantity of foodComparable levelsEatingPrevalence and Correlates of DSM-5–Defined Eating Disorders in a Nationally Representative Sample of U.S. Adults
Udo T, Grilo CM. Prevalence and Correlates of DSM-5–Defined Eating Disorders in a Nationally Representative Sample of U.S. Adults. Biological Psychiatry 2018, 84: 345-354. PMID: 29859631, PMCID: PMC6097933, DOI: 10.1016/j.biopsych.2018.03.014.Peer-Reviewed Original ResearchEarly weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change
Barnes RD, Ivezaj V, Pittman BP, Grilo CM. Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change. International Journal Of Eating Disorders 2018, 51: 558-564. PMID: 29637592, PMCID: PMC6002900, DOI: 10.1002/eat.22860.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentBinge-eating disorderLoss treatmentWeight lossBed statusWeight loss treatment outcomesOverweight/obesityWeight loss trialAverage weight lossWeight-related variablesPrognostic significancePrimary careTreatment outcomesTreatment responseLoss trialWeight trajectoriesTreatment studiesDisorder statusWeight changeOutcomesTreatmentIndividual responsesStatusPositive outcomesAssociations of parents' self, child, and other “fat talk” with child eating behaviors and weight
Lydecker JA, Riley KE, Grilo CM. Associations of parents' self, child, and other “fat talk” with child eating behaviors and weight. International Journal Of Eating Disorders 2018, 51: 527-534. PMID: 29542177, PMCID: PMC6002914, DOI: 10.1002/eat.22858.Peer-Reviewed Original ResearchConceptsFat talkParents of preadolescentsParents' selfChildren's eatingChild sexSecretive eatingNegative communicationWeight-related interventionsFront of childrenAdolescent girlsPeer groupEatingPreadolescentsParentsSelfAdolescentsChildrenDifferent formsTalkWeight variablesBehaviorOverweight/obesityAssociationGirlsIntervention
2017
Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care
Barnes RD, Ivezaj V, Martino S, Pittman BP, Paris M, Grilo CM. Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care. Journal Of Psychosomatic Research 2017, 104: 101-107. PMID: 29275778, PMCID: PMC5774024, DOI: 10.1016/j.jpsychores.2017.11.013.Peer-Reviewed Original ResearchConceptsBinge-eating disorderNutrition psychoeducationMotivational interviewingUsual careAttention control conditionWeight lossPrimary careBasic nutrition informationOverweight/obesityModerate weight lossPsychological improvementPsychoeducationMore weight lossMixed model analysisMixed-model analysisPrognostic significanceTreatment completionScalable combinationCurrent studyPercentage weight lossParticipantsBed statusNutrition informationCareGreater improvementBack to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up
Barnes RD, Ivezaj V, Martino S, Pittman BP, Grilo CM. Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up. Obesity 2017, 25: 2074-2078. PMID: 29086484, PMCID: PMC5705439, DOI: 10.1002/oby.21972.Peer-Reviewed Original ResearchConceptsWeight loss interventionPrimary careBinge-eating disorderWeight lossNutrition psychoeducationLoss interventionSecondary end point analysisWeight loss 12 monthsAttention-controlled comparisonMotivational interviewingMIC patientsEnd-point analysisTreatment conclusionOne-yearBed statusSmall effect sizesCareMonthsPatientsInterventionEffect sizeTreatmentPsychoeducationLong-term impactMixed models“I only watch for the commercials”: Messages about weight, eating and race in Super Bowl advertisements
Lydecker JA, Izzo A, Spielberger G, Grilo CM. “I only watch for the commercials”: Messages about weight, eating and race in Super Bowl advertisements. International Journal Of Clinical Practice 2017, 71: e13026. PMID: 28941009, PMCID: PMC5728649, DOI: 10.1111/ijcp.13026.Peer-Reviewed Original ResearchCorrelates of weight-related quality of life among individuals with binge eating disorder before and after cognitive behavioral therapy
Mason TB, Crosby RD, Kolotkin RL, Grilo CM, Mitchell JE, Wonderlich SA, Crow SJ, Peterson CB. Correlates of weight-related quality of life among individuals with binge eating disorder before and after cognitive behavioral therapy. Eating Behaviors 2017, 27: 1-6. PMID: 28843136, PMCID: PMC5700842, DOI: 10.1016/j.eatbeh.2017.08.001.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyED psychopathologyBody mass indexWeight-related qualityBehavioral therapyEnd of treatmentSelf-report measuresPhysical functionSubjective bingeDisorder psychopathologyPublic distressPsychosocial variablesLongitudinal associationsPsychosocial factorsPsychopathologyNumber of EDsCopingBingeCurrent studyMass indexAvailable treatmentsDistressPredictor variablesFollowing associationsWeight lossEvaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers
White MA, Ivezaj V, Grilo CM. Evaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers. Journal Of Health Psychology 2017, 24: 1796-1806. PMID: 28810442, DOI: 10.1177/1359105317701560.Peer-Reviewed Original ResearchConceptsSmoking cessation treatmentCessation treatmentObese smokersCognitive-behavioral treatmentBehavioral treatmentCognitive-behavioral smoking cessation treatmentBehavioral smoking cessation treatmentNicotine replacement therapyOverweight/obesityCessation ratesReplacement therapyRegular smokersStandard treatmentHealth educationLarger studySmokersPerson assessmentPilot studyCommunity volunteersTreatmentLess weightKey outcomesParticipantsObesityTherapyRumination in Patients with Binge‐Eating Disorder and Obesity: Associations with Eating‐Disorder Psychopathology and Weight‐bias Internalization
Wang SB, Lydecker JA, Grilo CM. Rumination in Patients with Binge‐Eating Disorder and Obesity: Associations with Eating‐Disorder Psychopathology and Weight‐bias Internalization. European Eating Disorders Review 2017, 25: 98-103. PMID: 28078784, PMCID: PMC5318238, DOI: 10.1002/erv.2499.Peer-Reviewed Original ResearchConceptsShape/weightWeight bias internalizationEating-disorder psychopathologyBinge-eating disorderCognitive processesGreater eating-disorder psychopathologyImportant cognitive processesOvervaluation of shapeGreater weight bias internalizationHierarchical multiple regressionTreatment-seeking patientsGreater ruminationRuminationDiscrimination experiencesPhysical healthPsychopathologyNegative attitudesMultiple regressionOvervaluationObesity treatmentComorbid obesityAttitudesDisordersExperienceFindings
2016
Perceived weight discrimination and chronic medical conditions in adults with overweight and obesity
Udo T, Purcell K, Grilo CM. Perceived weight discrimination and chronic medical conditions in adults with overweight and obesity. International Journal Of Clinical Practice 2016, 70: 1003-1011. PMID: 28032427, PMCID: PMC5215793, DOI: 10.1111/ijcp.12902.Peer-Reviewed Original ResearchConceptsChronic medical conditionsStressful life eventsMedical conditionsObese adultsPhysical activityMajor chronic medical conditionsWeight discriminationOverweight/obese adultsLife eventsAcute stressful life eventsSociodemographic variablesOverweight/obesityPerceived Weight DiscriminationMultiple logistic regressionGender-stratified analysesDifferent medical conditionsSocioeconomic burdenMyocardial infarctionHigh cholesterolCardiac conditionsStomach ulcersLogistic regressionRelated conditionsObesityHealth effectsChildren of parents with BED have more eating behavior disturbance than children of parents with obesity or healthy weight
Lydecker JA, Grilo CM. Children of parents with BED have more eating behavior disturbance than children of parents with obesity or healthy weight. International Journal Of Eating Disorders 2016, 50: 648-656. PMID: 27859458, PMCID: PMC5429220, DOI: 10.1002/eat.22648.Peer-Reviewed Original ResearchConceptsBinge-eating disorderChild weightChildren's bingeEating-disorder psychopathologyHigher child weightCross-sectional findingsChild overweightProspective confirmationChildren's eatingChild feedingChild overeatingDietary restrictionObesityClinical interventionsPrevention effortsEating Disorder BehaviorsDisordersBingePreliminary evidencePotential factorsEatingCurrent studyLimited literatureCore featuresOBBinge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity
Masheb RM, Dorflinger LM, Rolls BJ, Mitchell DC, Grilo CM. Binge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity. Obesity 2016, 24: 2491-2496. PMID: 27797154, PMCID: PMC5172456, DOI: 10.1002/oby.21664.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPsychological functioningBinge abstinencePsychological outcomesCombination of CBTBehavioral therapyBingeRecall interviewsFunctioningAbstinence ratesDietary recall interviewsReduced energy intakeAbstinenceSignificant reductionWeight statusPsychiatric morbidityGreater improvementAdult patientsDietary counselingFruit intakeSugar intakeEnergy intakeDisordersAbstinentComplete cessationPreferred descriptions for loss of control while eating and weight among patients with binge eating disorder
Roberto CA, Galbraith K, Lydecker JA, Ivezaj V, Barnes RD, White MA, Grilo CM. Preferred descriptions for loss of control while eating and weight among patients with binge eating disorder. Psychiatry Research 2016, 246: 548-553. PMID: 27821368, PMCID: PMC5161684, DOI: 10.1016/j.psychres.2016.09.045.Peer-Reviewed Original ResearchExamining binge‐eating disorder and food addiction in adults with overweight and obesity
Ivezaj V, White MA, Grilo CM. Examining binge‐eating disorder and food addiction in adults with overweight and obesity. Obesity 2016, 24: 2064-2069. PMID: 27558207, PMCID: PMC5039112, DOI: 10.1002/oby.21607.Peer-Reviewed Original ResearchConceptsOverweight/obesityBinge-eating disorderFood addictionFA criteriaPresence of BEDControl groupBody mass indexHealth-related behaviorsHigher depression scoresSubgroup of adultsMass indexDepression scoresObesityWeb-based surveyBED criteriaFA groupGreater pathologyOverweightPathologyDisordersAdultsGroupMost measuresAddictionIndividualsWords will never hurt me? Preferred terms for describing obesity and binge eating
Lydecker JA, Galbraith K, Ivezaj V, White MA, Barnes RD, Roberto CA, Grilo CM. Words will never hurt me? Preferred terms for describing obesity and binge eating. International Journal Of Clinical Practice 2016, 70: 682-690. PMID: 27354290, PMCID: PMC4965320, DOI: 10.1111/ijcp.12835.Peer-Reviewed Original Research