2016
In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity
Boisvert A, Jones S, Issop L, Erythropel HC, Papadopoulos V, Culty M. In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity. Environmental Research 2016, 150: 496-512. PMID: 27423704, DOI: 10.1016/j.envres.2016.06.033.Peer-Reviewed Original ResearchConceptsOrgan cultureDose-response studySensitive developmental windowsFetal Leydig cellsGerm cellsAndrogen productionTesticular functionBiphasic effectSteroid productionReproductive toxicityLeydig cellsSpermatogonial cell lineMonoester metabolitesNeonatal testisSafe alternativeScreening toolDevelopment of compoundsVivo evaluationCell linesMA-10Developmental windowCell line dataCell survivalEndocrine disruptorsPromising compounds
2014
Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure
Erythropel HC, Maric M, Nicell JA, Leask RL, Yargeau V. Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure. Applied Microbiology And Biotechnology 2014, 98: 9967-9981. PMID: 25376446, DOI: 10.1007/s00253-014-6183-8.Peer-Reviewed Original ResearchConceptsDEHP exposureHuman exposureDaily human exposureChronic illnessTolerable daily intake valuesLevels of DEHPBreakdown productsDaily intake valuesUbiquitous environmental contaminantsHospital environmentHigh levelsIntake valuesExposureEndocrine disruptorsHospital equipmentImpact assessment studiesDEHPLatter exposureRiskEnvironmental fateAlternative plasticizersDEHP contaminationBottled waterPatientsLevels