2013
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task
Nunes E, Randall P, Estrada A, Epling B, Hart E, Lee C, Baqi Y, Müller C, Correa M, Salamone J. Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task. Psychopharmacology 2013, 231: 727-736. PMID: 24136220, PMCID: PMC4468782, DOI: 10.1007/s00213-013-3285-4.Peer-Reviewed Original ResearchConceptsPro-inflammatory cytokines interleukinIL-1βMotivational symptomsEffort-related choice behaviorCytokines interleukinLow dosesEffort-related motivational effectsEffort-related motivational symptomsPro-inflammatory cytokinesLoss of appetiteInvolvement of cytokinesAdministration of cytokinesRatio 5 leverSame dose rangeAdenosine A2A antagonistsEffort-related impairmentsCore body temperatureObjectivesThe present experimentsChow intakeMSX-3ResultsIL-1βAvailable chowFood intakeTendency of ratsA2A antagonists
2012
The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions
Santerre J, Nunes E, Kovner R, Leser C, Randall P, Collins-Praino L, Cruz L, Correa M, Baqi Y, Müller C, Salamone J. The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions. Pharmacology Biochemistry And Behavior 2012, 102: 477-487. PMID: 22705392, DOI: 10.1016/j.pbb.2012.06.009.Peer-Reviewed Original ResearchConceptsMSX-3Amino acid ester prodrugsTreatment of depressionDorsal striatal functionDopamine D2 receptorsSame dose rangeNucleus accumbens coreEffort-related choice behaviorConcurrent leverOral tremorD2 antagonistIntraperitoneal administrationActive dosesLocomotor suppressionMotor functionStriatal functionD2 receptorsAnxiogenic effectsMotor impairmentSelective adenosineAnimal modelsMotivational symptomsAccumbens coreAntiparkinsonian profileEster prodrugs
2010
The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
Randall P, Vemuri V, Segovia K, Torres E, Hosmer S, Nunes E, Santerre J, Makriyannis A, Salamone J. The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior. Pharmacology Biochemistry And Behavior 2010, 97: 179-184. PMID: 20713079, PMCID: PMC3522179, DOI: 10.1016/j.pbb.2010.07.021.Peer-Reviewed Original ResearchConceptsAppetite suppressant drugsFood-motivated behaviorHigh-fat dietCentral nervous systemFood-reinforced behaviorSame dose rangeCB1 inverse agonistsUndesirable side effectsChow intakeIntraperitoneal administrationAM6545CB1 receptorsAppetite suppressantsCannabinoid antagonistFood intakeHigh doseSide effectsNervous systemPoor penetrabilityInverse agonistNeutral antagonistsDose rangeMild suppressionIntakeAntagonist
2009
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats
Sink K, Segovia K, Nunes E, Collins L, Vemuri V, Thakur G, Makriyannis A, Salamone J. Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. Psychopharmacology 2009, 206: 223-232. PMID: 19588124, PMCID: PMC4425366, DOI: 10.1007/s00213-009-1602-8.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBehavior, AnimalConditioning, OperantDose-Response Relationship, DrugDrug Administration RoutesDrug InteractionsEatingFood DeprivationInjections, IntraventricularMaleMotor ActivityPiperidinesPyrazolesRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Reinforcement ScheduleReinforcement, PsychologyConceptsFood-reinforced behaviorCB1 receptorsLocomotor suppressionFood-motivated behaviorCannabinoid CB1 receptorsCB1 neutral antagonistsSame dose rangeModulation of locomotionIntracerebroventricular administrationICV administrationLocus of actionLower brainstemReceptor transmissionPeripheral receptorsSystemic administrationLateral ventricleAppetite suppressantsNucleus accumbensAM251AM4113Inverse agonistNeutral antagonistsDose rangeAdministrationReceptors