2012
Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences
Randall P, Pardo M, Nunes E, Cruz L, Vemuri V, Makriyannis A, Baqi Y, Müller C, Correa M, Salamone J. Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences. PLOS ONE 2012, 7: e47934. PMID: 23110135, PMCID: PMC3478264, DOI: 10.1371/journal.pone.0047934.Peer-Reviewed Original ResearchMeSH Keywords3,3'-DiaminobenzidineAdenosine A2 Receptor AntagonistsAnalysis of VarianceAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsChoice BehaviorDopamineDopamine and cAMP-Regulated Phosphoprotein 32Dopamine AntagonistsFeeding BehaviorHaloperidolImmunohistochemistryIndividualityMalePiperidinesPyrazolesRatsRats, Sprague-DawleyXanthinesConceptsProgressive ratioLever pressesPrimary food motivationNucleus accumbens coreCB1 inverse agonistsFood-seeking behaviorChow intakeMSX-3DA transmissionDA antagonismDopaminergic modulationDrug treatmentHigh respondersLaboratory chowLow respondersChow consumptionEffort-related processesSignal transduction activityAccumbens coreMesolimbic dopaminePharmacological studiesFood-reinforced tasksInverse agonistBehavioral activationFood motivationTHE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND
Salamone J, Correa M, Nunes E, Randall P, Pardo M. THE BEHAVIORAL PHARMACOLOGY OF EFFORT‐RELATED CHOICE BEHAVIOR: DOPAMINE, ADENOSINE AND BEYOND. Journal Of The Experimental Analysis Of Behavior 2012, 97: 125-146. PMID: 22287808, PMCID: PMC3266736, DOI: 10.1901/jeab.2012.97-125.Peer-Reviewed Original ResearchConceptsEffort-related choice behaviorDA depletionAccumbens DA depletionsNucleus accumbens DAAccumbens DAFood-reinforced behaviorDA transmissionMesolimbic DAPsychomotor slowingEffort-related functionsNeurological disordersFood-reinforced tasksBrain structuresDrug abuseAccumbens DA transmissionBehavioral pharmacologyHigh response requirementsRatsBrain systemsPresent reviewPrimary reinforcerAntagonism
2009
The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure
Mott A, Nunes E, Collins L, Port R, Sink K, Hockemeyer J, Müller C, Salamone J. The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure. Psychopharmacology 2009, 204: 103. PMID: 19132351, PMCID: PMC2875244, DOI: 10.1007/s00213-008-1441-z.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A1 Receptor AntagonistsAdenosine A2 Receptor AntagonistsAnimalsBehavior, AnimalChoice BehaviorConditioning, OperantDopamine AntagonistsDose-Response Relationship, DrugDrug InteractionsHaloperidolMaleMaze LearningMotivationNucleus AccumbensPhysical ExertionPsychomotor PerformanceRatsRats, Sprague-DawleyReceptor, Adenosine A1Receptors, Adenosine A2Reinforcement ScheduleXanthinesConceptsEffort-related choiceMSX-3Antagonist haloperidolAdenosine A2A antagonist MSX-3Receptor antagonist MSX-3Adenosine A2A antagonismDA antagonist haloperidolDopamine antagonist haloperidolEffects of haloperidolEffort-related decision makingFood-seeking behaviorA2A antagonismDA transmissionUntreated ratsA1 antagonistD2 receptorsPsychiatric symptomsAdenosine A2APsychomotor slowingA1 antagonismEffort-related processesBrain circuitryFood-reinforced tasksHaloperidolBehavioral activation