2023
Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders
Nunes E, Addy N, Conn P, Foster D. Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders. The Annual Review Of Pharmacology And Toxicology 2023, 64: 277-289. PMID: 37552895, PMCID: PMC10841102, DOI: 10.1146/annurev-pharmtox-051921-023858.Peer-Reviewed Original ResearchCholinergic neuronsMuscarinic acetylcholine receptor subtypesDA neuron activityMidbrain DA neuronsAcetylcholine receptor subtypesMood-related disordersPotential clinical implicationsDA circuitryDA neuronsDA releaseMuscarinic receptorsCholinergic regulationReceptor subtypesDopamine systemNeuron activityClinical implicationsNeuropsychiatric disordersDopamine signalingNumerous disordersSubtypesNumerous receptorsDisordersNeuronsReceptorsPublication dateVentral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner
Nunes E, Kebede N, Haight J, Foster D, Lindsley C, Conn P, Addy N. Ventral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner. Journal Of Pharmacology And Experimental Therapeutics 2023, 385: jpet-ar-2022-001438. PMID: 36828630, PMCID: PMC10108441, DOI: 10.1124/jpet.122.001438.Peer-Reviewed Original ResearchConceptsNucleus accumbens coreVentral tegmental areaM5 receptorsDA releaseMale ratsVTA infusionsDepressive disorderNucleus accumbensMuscarinic M5 receptorsSelective negative allosteric modulatorM5 muscarinic receptorsNegative allosteric modulatorsEffort-related choicePhasic DA releasePotential sex differencesSex-specific mannerACh toneVTA administrationCholinergic effectsMuscarinic receptorsFemale ratsTegmental areaPreclinical modelsDopamine releaseTherapeutic target
2022
Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders
Nunes EJ, Kebede N, Bagdas D, Addy NA. Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders. Journal Of The Experimental Analysis Of Behavior 2022, 117: 404-419. PMID: 35286712, PMCID: PMC9743782, DOI: 10.1002/jeab.747.Peer-Reviewed Original ResearchConceptsMood disordersSubstance useActivational componentsMotivated behaviorComorbid substance useMesolimbic dopamine systemDA releaseCholinergic activityCholinergic transmissionImportant neuromodulatorCholinergic dysregulationDA regulationDopamine systemDA signalingActivational aspectsDisease statesDisordersAversive stimuliPossible roleHealthy stateCholinergicAcetylcholineStimuliEtiologyIllness