2001
Cortical instability and the mechanism of mania: a neural network simulation and perceptual test
Hoffman R, Quinlan D, Mazure C, McGlashan T. Cortical instability and the mechanism of mania: a neural network simulation and perceptual test. Biological Psychiatry 2001, 49: 500-509. PMID: 11257235, DOI: 10.1016/s0006-3223(00)01071-4.Peer-Reviewed Original ResearchConceptsCognitive speedNeural representationNeural network simulationAuditory continuous performance taskNecker cube perceptionContinuous performance taskSimple perceptual tasksPerceptual tasksPerceptual testsPerformance taskNecker cubeCube taskHuman subject studiesReversal rateCortical noiseSubject studyIndiscriminate responseNormal control subjectsStick figuresTaskSchizophreniaRepresentationNeural networkControl subjectsStimuli
1997
The Expanding Indications for Clozapine
Young C, Longhurst J, Bowers M, Mazure C. The Expanding Indications for Clozapine. Experimental And Clinical Psychopharmacology 1997, 5: 216-234. PMID: 9260069, DOI: 10.1037/1064-1297.5.3.216.Peer-Reviewed Original ResearchConceptsUnique pharmacodynamic profileUse of clozapineTreatment-resistant schizophreniaTraditional drug treatmentExpanding IndicationsClozapine treatmentNeurologic conditionsPharmacodynamic profileClinical indicationsDrug treatmentMood disordersEffective treatmentClozapineSubstance abuseChildhood schizophreniaRelevant literatureSchizophreniaDisordersTreatmentAggressive behaviorIndicationsInitial rationaleAgranulocytosisPatientsBody of literature