2001
Ibuprofen as a Chemesthetic Stimulus: Evidence of a Novel Mechanism of Throat Irritation
Breslin P, Gingrich T, Green B. Ibuprofen as a Chemesthetic Stimulus: Evidence of a Novel Mechanism of Throat Irritation. Chemical Senses 2001, 26: 55-65. PMID: 11124216, DOI: 10.1093/chemse/26.1.55.Peer-Reviewed Original ResearchConceptsCapsaicin-sensitive receptorsThroat irritationRatings of irritationReceptor mechanismsSensory irritationNon-steroidal anti-inflammatory drug ibuprofenIrritationAnti-inflammatory drug ibuprofenOral irritantsThroatReceptorsNovel mechanismStimulationIbuprofenChemesthetic propertiesChemesthetic stimuliBuffering agentDrug ibuprofenPrickAgentsChemesthetic effects
2000
Menthol desensitization of capsaicin irritation Evidence of a short-term anti-nociceptive effect
Green B, McAuliffe B. Menthol desensitization of capsaicin irritation Evidence of a short-term anti-nociceptive effect. Physiology & Behavior 2000, 68: 631-639. PMID: 10764892, DOI: 10.1016/s0031-9384(99)00221-8.Peer-Reviewed Original ResearchConceptsInterstimulus intervalFinal experimentPrevious researchSecond experimentCapsaicin stimuliCapsaicin-sensitive fibersAnti-nociceptive effectsStimuliSelfSecond exposureAntinociceptive effectTopical analgesicsSensory irritationCapsaicinPerceptionExposureDesensitizationCrossdesensitizationStimulationImplicationsMin
1993
The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency
Green B, Shaffer G. The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 1993, 53: 323-334. PMID: 8351161, DOI: 10.1016/0304-3959(93)90228-h.Peer-Reviewed Original ResearchConceptsInter-stimulus intervalTopical exposureIntensity of itchingUse of capsaicinApplication of capsaicinHand-held dynamometerDuration of sensitizationSensations of itchingTest 24 hFifth exposureDay 1Day 2Sensory irritationCapsaicinItchingOverall sensitivityDesensitizationLess sensitizationSensitizationSensory responsesMarked individual differencesTime courseDifferential effectsItchPungent sensation