Angelique Bordey, PhD
Cards
About
Titles
Rothberg Professor of Neurosurgery
Vice Chair of Research, Neurosurgery, NeurosurgeryBiography
Dr. Angélique Bordey holds the rank of Professor of Neurosurgery, and Cellular & Molecular Physiology. Dr. Bordey is an active participant in teaching and training of graduate and medical students at Yale School of Medicine. Dr. Bordey is an Editor for several journals and on the advisory board of CURE epilepsy and the TSC Alliance preclinical consortium. She has served as a permanent member on several grant review committees and NIH study sections. Finally, she is a McKnight awardee and holds several federal and foundation grants as well as patents for the treatment of epilepsy.
Appointments
Neurosurgery
ProfessorPrimaryCellular & Molecular Physiology
ProfessorSecondary
Other Departments & Organizations
- Bordey Lab
- Cellular & Molecular Physiology
- Center for Brain & Mind Health
- Graduate Program in Cellular and Molecular Physiology
- Green College Affiliates
- Interdepartmental Neuroscience Program
- Molecular Medicine, Pharmacology, and Physiology
- Neural Disorders
- Neuroscience Track
- Neurosurgery
- Program in Translational Biomedicine (PTB)
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- PhD
- Louis Pasteur University, Neuroscience (1995)
- MS
- University Louis Pasteur, Neurophysiology (1992)
- MS
- National School of Engineering, Chemistry (1991)
- Postdoctoral Fellow
- University of Alabama at Birmingham
Research
Overview
Our attention has been focused on the mammalian Target of Rapamycin, mTOR. mTOR is a converging point in cell signaling, or in other terms an intracellular hub, that receives signals from diverse intracellular routes and extracellular ligands. Importantly, mTOR is dysregulated in many neurological disorders. These disorders referred to as mTORopathies include (but are not limited to) Tuberous Sclerosis Complex (TSC), autism, Alzheimer's disease, and Schizophrenia. We have focused on TSC, to better understand the circuit basis of epilepsy and autism.
Our work has the following three lines of research related to the following keywords: mTOR- Neural stem cell- Neurogenesis-Cognitive functions- mTORopathies
1. Understanding how a circuit is formed from neural stem cells to synaptic integration in health and in developmental mTORopathies.
2. Preventing the formation of brain malformations and associated neurological symptoms in TSC and other developmental mTORopathies.
3. Understanding the circuit and molecular basis of autism in TSC. For this we are developing novel rodent models of autism in TSC.
Medical Subject Headings (MeSH)
Academic Achievements and Community Involvement
Links & Media
News
- January 04, 2022
Angelique Bordey, PhD, Receives Scientific Innovations Award from Brain Research Foundation
- November 18, 2020
Scientists Closer to Understanding Cause of Severe Treatment-Resistant Epilepsy
- July 05, 2020
Fixing dysregulated pathways
- February 27, 2020
Drug shows promise in reducing seizures in those with severe epilepsy