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CXCL12 drives natural variation in coronary artery anatomy across diverse populations

Coronary dominance is a clinically important developmental phenotype that dictates whether the left or right coronary arteries perfuse the back of the heart. Genome-wide association studies and downstream experiments identified CXCL12, a gene previously linked to coronary artery disease, as a driver of coronary dominance during fetal development. These findings show that common genetic variants influence developmental processes in humans, with implications for disease onset and revascularization efforts later in life.

Source: Cell
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  • Yale Physiology researchers discover how hibernating squirrels conquer thirst

    The laboratories of Prof. Elena Gracheva (C&M Physiology, Neuroscience, Kavli Institute) and Prof. Slav Bagriantsev (C&M Physiology) discover a neurophysiological mechanism that enables long-term survival of hibernating squirrels without water. The study is published in the Science journal https://www.science.org/doi/10.1126/science.adp8358

    Source: Neurophysiology of resting rodents could hold secrets to suspended animation
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  • Can Type 2 Diabetes Be Reversed?

    Research shows that most cases of type 2 diabetes can be prevented through lifestyle interventions. But if you already have the condition, can it be reversed? Yale School of Medicine experts weigh in.

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  • Rare Disease Celebration: Feb. 21

    Yale School of Medicine, the Department of Genetics, Yale New Haven Health, and the National Organization for Rare Disorders are hosting a Rare Disease Celebration on Friday, Feb. 21 from 1 – 5 p.m. at the Greenberg Conference Center.

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  • Engineering a genomically recoded organism with one stop codon

    Michael Grome, a postdoctoral associate in molecular, cellular, and developmental biology at Yale and first author of the study, likened codons to three-letter words within a sentence in the genetic recipe for life. “A lot of these words are equivalent, or synonymous,” Grome said. “We set out to add more ingredients for building proteins, so we took three of these words for ‘stop’ and made them one. Two words were removed, then we re-engineered the cell so they were ‘freed’ for new function. We then engineered a cell that recognized the word to say something new, to represent a new ingredient.”

    Source: Nature
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  • Yale Urology Research [Q4: October-December 2024]

    The following is a comprehensive list of Yale Urology publications/presentations for the fourth quarter of calendar year 2024. The listing is in descending published date order and features primary faculty and trainee work. Most items include links to the full study or presentation and provides portions of the abstract / summary.

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