Yale Researchers Take Stem Cells One Step Closer to Replacing Parathyroid Gland Function
Yale investigators have developed a multistep process that models the biological instructions to create parathyroid gland cells from pluripotent stem cells, a significant milestone along the path toward helping people who lack the hormones released by parathyroid glands.
Dr. Richard Bucala named the Von Zedtwitz Professor
Dr. Richard Bucala, newly appointed as the Waldemar Von Zedtwitz Professor of Medicine, Pathology, and Epidemiology and Public Health, studies immune system regulation with a focus on how protective responses can lead to immunopathology and disease.
Yale Researchers Crack the Code of a Rare, Inherited Anemia
Yale pediatrician and geneticist Patrick Gallagher, M.D., studies hereditary spherocytosis (HS), an inherited disease associated with hemolytic anemia, when red blood cells are destroyed faster than they are produced due to abnormal membranes. A novel mutation in the gene that encodes alpha-spectrin, a protein essential for normal red blood cell membranes, is responsible for many cases of recessive hereditary spherocytosis (rHS), the most severe form of the disease, reports Gallagher’s team
Urine Biomarkers Could Improve Diagnosis of Serious Kidney Allergic Reaction
A team led by Johns Hopkins Medicine researchers says it has identified two protein biomarkers in urine that may one day be used to better diagnose acute interstitial nephritis (AIN), an underdiagnosed but treatable kidney disorder that impairs renal function in the short term and can lead to chronic kidney disease, permanent damage or renal failure if left unchecked.Source: Technology Networks
New Strategies Needed for TKI Resistance in EGFR+ Lung Cancer
The development of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of EGFR-mutant non–small cell lung cancer (NSCLC) in recent years, but new strategies are needed to overcome resistance mechanisms that promote disease recurrence, Katerina A. Politi, PhD, said during a 2019 ASCO session featuring emerging research.Source: OncLive
Researchers Identify Stem Cell Source of Key Process in Female Reproduction
Each month during women’s reproductive years, the uterus sheds and regenerates the tissue lining its walls in preparation for a pregnancy or the next cycle. The process behind this age-old and essential part of human reproduction is not well understood. But recent research led by Yale pathologist Wang Min identifies stem cells and a gene that contribute to this monthly event.
Mustaches may lower risk of skin cancer-associated lesions on lips
Having a mustache might lower a person’s risk of developing a specific kind of pre-cancerous lesion on the lower lip known as actinic keratosis, according to a new study published in the Journal of the American Academy of Dermatology.Source: ABC News
Lung Cancer Research Foundation Announces New Scientific Advisory Board Chair
NEW YORK, May 23, 2019 /PRNewswire/ -- The Lung Cancer Research Foundation (LCRF) today announced that Dr. Katerina Politi has been named the chair of its Scientific Advisory Board. Politi, an Associate Professor of Pathology and Internal Medicine (in the Section of Medical Oncology) at Yale School of Medicine, will be taking over the role from Dr. James B. Dougherty, who has held the chair position for 14 years.Source: Yahoo! Finance
Potential Metastatic Prostate Cancer Biomarker Identified
While skin cancer is still the most common form of cancer among men, prostate cancer is not far behind, unfortunately. Current statistics say that roughly 1 in 9 men will be diagnosed with prostate cancer during their lifetime. Though prostate cancer can be a serious disease, thankfully most men diagnosed with prostate cancer do not die from it. In fact, more than 2.9 million men in the United States who have been diagnosed with prostate cancer at some point are still alive today.Source: Genetic Engineering and Biotechnology News
Yale Cancer Center Scientists Receive Grant to Advance Lung Cancer Research
Katerina Politi, PhD and Don Nguyen, PhD, members of the Signal Transduction Research Program at Yale Cancer Center (YCC), have received a 5-year, nearly $4 million National Cancer Institute (NCI) grant to support Lung Cancer research.
Genetic Sequencing Uncovers Causes for Mysterious Liver Disease in Adults
In up to 30% of individuals with chronic liver disease, the cause is unknown. To test for possible genetic factors in such cases, Yale researchers conducted whole-exome sequencing for a small group of patients, finding specific mutations that would have otherwise been missed. The results led to accurate diagnoses and informed treatment for a subset of the patient participants, the researchers said.
New Center to Harness Burgeoning Data
The Center for Biomedical Data Science (CBDS) is one part clearinghouse for the newest data-related ideas; one part incubator for ways to educate students, trainees, and faculty on what data can offer; and one part an innovator of data techniques to advance biomedical science and data science. As CBDS matures, additional pursuits are sure to follow.Source: Medicine@Yale