2020
RNA-binding proteins in neurological development and disease
Prashad S, Gopal PP. RNA-binding proteins in neurological development and disease. RNA Biology 2020, 18: 972-987. PMID: 32865115, PMCID: PMC8216196, DOI: 10.1080/15476286.2020.1809186.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRNA-binding proteinGene expressionDisease-linked RNA-binding proteinsHigh-throughput transcriptomic analysisRNA processing stepsAberrant RNA metabolismAberrant RNA processingRecent exciting studiesRNA processingRNA metabolismMRNA traffickingAlternative splicingMultifunctional proteinTranscriptomic analysisSplicing misregulationMRNA stabilityMolecular mechanismsProtein resultsNeuronal homeostasisNeurodevelopmental defectsNeuronal proteinsFunctional consequencesPleiotropic effectsSpatiotemporal controlProtein
2019
Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
Stavoe A, Gopal P, Gubas A, Tooze S, Holzbaur E. Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. ELife 2019, 8: e44219. PMID: 31309927, PMCID: PMC6634969, DOI: 10.7554/elife.44219.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAged miceNovel therapeutic targetLate-onset neurodegenerative diseasesAge-associated neurodegenerationAge-related declineAged neuronsRisk factorsLateral sclerosisParkinson's diseaseTherapeutic targetLC3B-positive autophagosomesNeurodegenerative diseasesMammalian neuronsNeuronsSignificant decreaseDiseaseRate of autophagy