Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury
Kirkiles-Smith NC, Harding MJ, Shepherd BR, Fader SA, Yi T, Wang Y, McNiff JM, Snyder EL, Lorber MI, Tellides G, Pober JS. Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury. Transplantation 2009, 87: 189-197. PMID: 19155972, PMCID: PMC2776641, DOI: 10.1097/tp.0b013e318192e05d.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAdult Stem CellsAnimalsAntigens, CDAntigens, CD34Antigens, Differentiation, MyelomonocyticArteriesDisease Models, AnimalGraft RejectionHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansInterleukin Receptor Common gamma SubunitLipopolysaccharide ReceptorsMacrophagesMiceMice, Inbred NODMice, KnockoutMice, SCIDReceptors, Cell SurfaceSkinSkin TransplantationT-LymphocytesTransplantation, HomologousWhole-Body IrradiationConceptsT cellsImmunodeficient micePeripheral blood monuclear cellsHematopoietic stem cellsAllogeneic T cellsHuman cell engraftmentHumanized mouse modelHuman monocytes/macrophagesRole of macrophagesArterial interposition graftsMonocytes/macrophagesImmunodeficient mouse hostsStem cellsHuman skinAllograft injuryArtery graftAdoptive transferInterposition graftPeripheral bloodTransplant rejectionIntimal expansionHuman allograftsMouse modelCell engraftmentTissue graft