2021
Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis
González IA, Fuller LD, Zhang X, Papke DJ, Zhao L, Zhang D, Liao X, Liu X, Fiel MI, Zhang X. Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis. American Journal Of Clinical Pathology 2021, 157: 434-442. PMID: 34596220, DOI: 10.1093/ajcp/aqab142.Peer-Reviewed Original ResearchConceptsAmiodarone-induced liver injuryAlcoholic steatohepatitisScoring systemLiver injuryTest cohortDifferent histologic featuresHepatocyte ballooning degenerationMallory-Denk bodiesNeutrophilic inflammationHistologic featuresPericellular fibrosisMacrovesicular steatosisBallooning degenerationHistologic differencesLiver parenchymaCohortSteatohepatitisInjuryFurther validationInitial studyZone 1SatellitosisCholestasisSteatosisInflammationPathological characteristics of liver sinusoidal thrombosis in COVID‐19 patients: A series of 43 cases
Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Pathological characteristics of liver sinusoidal thrombosis in COVID‐19 patients: A series of 43 cases. Hepatology Research 2021, 51: 1000-1006. PMID: 34260803, PMCID: PMC8444906, DOI: 10.1111/hepr.13696.Peer-Reviewed Original ResearchCOVID-19 patientsVon Willebrand factorLiver injuryPatient's liverPapa Giovanni XXIII HospitalHigher serum ALTLiver sinusoidal endothelial cellsLiver biopsy samplesSinusoidal endothelial cellsSinusoidal thrombosisSerum ALTAST levelsPathological characteristicsHigher fibrinogenPlatelet microthrombiBiopsy samplesMultiple organsPatientsDisease severityCoronavirus diseaseLiverEndothelial cellsInjurySecondary damageWillebrand factorLiver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy
McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.Peer-Reviewed Original ResearchConceptsLiver sinusoidal endothelial cellsLiver injuryInterleukin-6Sinusoidal endothelial cellsAlanine aminotransferaseLiver histologyD-dimerCOVID-19Primary human liver sinusoidal endothelial cellsSARS-CoV-2 infectionHuman liver sinusoidal endothelial cellsEndothelial cellsSoluble glycoprotein 130IL-6 levelsSmall-interfering RNA knockdownJAK inhibitor ruxolitinibFactor VIII activityProinflammatory factorsInflammatory signalsLarge cohortInhibitor ruxolitinibVWF antigenEndotheliopathyPatientsInjury
2019
Histologic patterns of liver injury induced by anti-PD-1 therapy
Zhang D, Hart J, Ding X, Zhang X, Feely M, Yassan L, Alpert L, Soldevila-Pico C, Zhang X, Liu X, Lai J. Histologic patterns of liver injury induced by anti-PD-1 therapy. Gastroenterology Report 2019, 8: 50-55. PMID: 32467761, PMCID: PMC7244961, DOI: 10.1093/gastro/goz044.Peer-Reviewed Original ResearchAnti-PD-1 therapyAnti-PD-1 treatmentLiver function testsHistologic patternAutoimmune hepatitisAdvanced malignanciesLiver injuryAbnormal liver function testsAnti-PD-1 agentsClassical autoimmune hepatitisLiver chemistry testsMultiple advanced malignanciesPD-1 inhibitorsSevere liver injuryCell death 1Different histologic patternsCholestatic injuryHepatitis panelSteroid therapyAbdominal painAcute hepatitisGastrointestinal symptomsImmunosuppressive therapyDrug cessationHistologic injury
2013
Histopathologic Manifestations of Drug-induced Hepatotoxicity
Zhang X, Ouyang J, Thung SN. Histopathologic Manifestations of Drug-induced Hepatotoxicity. Clinics In Liver Disease 2013, 17: 547-564. PMID: 24099017, DOI: 10.1016/j.cld.2013.07.004.Peer-Reviewed Original ResearchConceptsDrug-induced hepatotoxicityChronic liver diseaseLiver diseaseCareful medication historySpecific histopathologic patternAbnormal liver testsLiver testsResponsible drugSymptom onsetLiver injuryMedication historyCounter medicationsHistopathologic patternHistopathologic findingsDrug exposureHistopathologic manifestationsHepatobiliary diseaseCertain drugsSupplementary agentPrescription drugsHepatotoxicityHerbal productsLatent periodDiseaseDrugs